Results 71 to 80 of about 232,498 (309)
Arctic tree rings as recorders of variations in light availability [PDF]
, 2014 Annual growth ring variations in Arctic trees are often used to reconstruct surface temperature. In general, however, the growth of Arctic vegetation is limited both by temperature and light availability, suggesting that variations in atmospheric ...
Huybers, P., Stine, A. R.
core +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Модернизация, инновация, развитие, 2016 This article discusses the use of balance of labour resources and population and labour resources movements balance for the assessment of the current and future state of regional labor markets and migration linkages in the regions of the Russian Arctic ...
A. G. Korovkin +3 more
doaj +1 more source
What Does Climate Change Mean for the Arctic? How is Alaska Being Affected? [PDF]
, 2005 The Environmental and Energy Study Institute (EESI) held a Congressional briefing on March 15, 2005 on the Arctic Climate Impact Assessment (ACIA) 1 and climate change impacts already observed in Alaska.
Fredric A. Beck
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Effects of Uncertainty in Climate Inputs on Simulated Evapotranspiration and Runoff in the Western Arctic [PDF]
, 2006 Hydrological models require accurate precipitation and air temperature inputs in order to adequately depict water fluxes and storages across Arctic regions.
Frolking, Steve +3 more
core +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Community Response Strategies for Environmental Problems of Water Supply and Wastewater Disposal in Fairbanks, Alaska [PDF]
, 1975 This report examines the history of the response strategies of the Fairbanks, Alaska, community to problems of water supply and wastewater disposal.
Pearson, Roger W., Smith, Daniel W.
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source