Results 141 to 150 of about 161,658 (309)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Unprecedented decline of Arctic sea ice outflow in 2018. [PDF]

Nat Commun, 2022
Sumata H, de Steur L, Gerland S, Divine DV, Pavlova O.   +4 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

High Levels of Microplastics in the Arctic Sea Ice Alga Melosira arctica, a Vector to Ice-Associated and Benthic Food Webs. [PDF]

Environ Sci Technol, 2023
Bergmann M, Allen S, Krumpen T, Allen D.
europepmc   +1 more source

Holocene variability of surface and seep water advection to the Arctic Ocean - a multiproxy perspective from the aastern Fram Strait [PDF]

, 2011
Micropaleontological, geochemical, and sedimentological parameters of two sediment cores from the eastern Fram Strait have been studied to reconstruct the variability of surface and deep water advection and related fluctuations of the marginal ice zone ...
Werner, Kirstin
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Winter-to-Summer Transition of Bacterial and Archaeal Communities in Arctic Sea Ice. [PDF]

Microorganisms, 2022
Thiele S, Storesund JE, Fernández-Méndez M, Assmy P, Øvreås L.   +4 more
europepmc   +1 more source

Neoglacial cooling culminates in rapid sea ice oscillations in eastern Fram Strait [PDF]

, 2011
EGU2011-407 The spatial and temporal distribution of sea ice in the subpolar North Atlantic is mainly controlled by the advection of warm Atlantic Water via the Norwegian and West Spitsbergen Current in eastern Fram Strait.
Müller, Juliane, Spielhagen, Robert, Stein, Ruediger, Werner, Kirstin   +3 more
core  

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Database of daily Lagrangian Arctic sea ice parcel drift tracks with coincident ice and atmospheric conditions. [PDF]

Sci Data, 2023
Horvath S, Boisvert L, Parker C, Webster M, Taylor P, Boeke R, Fons S, Stewart JS.   +7 more
europepmc   +1 more source