Results 51 to 60 of about 2,283,779 (307)

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Shipborne visual observations of Arctic sea ice during cruise Oden1308

, 2018
Shipborne visual observations of Arctic sea ice during cruise ...
Sergey Ryabov (8022704), Ryabov, Sergey
core   +1 more source

Arctic Ice Ocean Prediction System: evaluating sea-ice forecasts during Xuelong's first trans-Arctic Passage in summer 2017

Journal of Glaciology, 2019
In an effort to improve the reliability of Arctic sea-ice predictions, an ensemble-based Arctic Ice Ocean Prediction System (ArcIOPS) has been developed to meet operational demands.
Longjiang Mu, Xi Liang, Qinghua Yang, Jiping Liu, Fei Zheng   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Spatiotemporal Variation Characteristics and Drivers of Winter Arctic Sea Ice Thickness Under the New Arctic Regime

Journal of Marine Science and Engineering
The “New Arctic” regime represents a prominent climatic feature of the Arctic Ocean under global warming, characterized by persistently low summer sea ice extent, a marked reduction in sea ice thickness, and an expansion of open water areas at high ...
Yaowei Yin, Xiaoyu Wang
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Modeled Arctic sea ice evolution through 2300 in CMIP5 extended RCPs [PDF]

The Cryosphere, 2014
Almost all global climate models and Earth system models that participated in the Coupled Model Intercomparison Project 5 (CMIP5) show strong declines in Arctic sea ice extent and volume under the highest forcing scenario of the representative ...
P. J. Hezel, T. Fichefet, F. Massonnet
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Shipborne visual observations of Arctic sea ice during Arctic Sunrise cruise ArcSun1209

, 2018
Shipborne visual observations of Arctic sea ice during Arctic Sunrise cruise ...
Stroeve, Julienne C, Julienne C Stroeve (8022683)   +1 more
core   +1 more source