Results 71 to 80 of about 32,514 (263)

Shipborne visual observations of Arctic sea ice during cruise Oden1209

, 2018
Shipborne visual observations of Arctic sea ice during cruise ...
Jürgen Weissenberger (8022701), Weissenberger, Jürgen   +1 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Shipborne visual observations of Arctic sea ice during cruise Oden1308

, 2018
Shipborne visual observations of Arctic sea ice during cruise ...
Sergey Ryabov (8022704), Ryabov, Sergey
core   +1 more source

The gravitationally consistent sea-level fingerprint of future terrestrial ice loss [PDF]

, 2013
We solve the sea-level equation to investigate the pattern of the gravitationally self-consistent sea-level variations (fingerprints) corresponding to modeled scenarios of future terrestrial ice melt.
R. T. W. L. Hurkmans, Bamber, J. L., Hurkmans, R. T. W. L., J. L. Bamber, Spada, G., SPADA, GIORGIO   +5 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Recirculation in the Fram Strait and transports of water in and north of the Fram Strait derived from CTD data [PDF]

, 2013
The volume, heat and freshwater transports in the Fram Strait are estimated from geostrophic computations based on summer hydrographic data from 1984, 1997, 2002 and 2004.
M. Marnela, P. B. Eriksson, Houssais, M.-N., A. Beszczynska-Möller, Rudels, B., Beszczynska-Möller, Agnieszka, Houssais, Marie-Noelle, B. Rudels, M.-N. Houssais, Beszczynska-Möller, A., Marnela, Marika, Eriksson, P. B., Rudels, Bert, Marnela, M.   +13 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Stable Isotopes as Tracers for Freshwater Fluxes into the North Atlantic

, 2010
The Arctic acts as both an indicator and a facilitator of global climate change. Many studies have identified the manifold changes in the Arctic hydrological system resulting from global warming.
Cox, Katharine A.
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source