Results 71 to 80 of about 2,283,779 (307)
ArcLeads: Daily sea-ice lead maps for the Arctic, 2002-2021, NOV-APR
, 2023 The presence of sea-ice leads represents a key feature of the Arctic sea ice cover. Leads promote the flux of sensible and latent heat from the ocean to the cold winter atmosphere and are thereby crucial for air-sea-ice-ocean interactions.
Willmes, Sascha +2 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Shipborne visual observations of Arctic sea ice during POLARSTERN cruise PS92
, 2018 Shipborne visual observations of Arctic sea ice during POLARSTERN cruise ...
Schulte-Kortnack, Sebastian +1 more
core +1 more source
Growth and motion at the Weddell Sea ice edge
, 2007 The formation of sea ice in the presence of turbulence was studied using data from drifting buoydeployments and ice sampling in the Weddell Sea during April 2000.
Doble, Martin Jonathan
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Shipborne visual observations of Arctic sea ice during Louis S. St-Laurent cruise LSL1308
, 2018 Shipborne visual observations of Arctic sea ice during Louis S.
Twedt, Judy, Judy Twedt (8022695)
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Shipborne visual observations of Arctic sea ice during Lance cruise LA1705
, 2018 Shipborne visual observations of Arctic sea ice during Lance cruise ...
Hajo Eicken (6963893), Eicken, Hajo
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Shipborne visual observations of Arctic sea ice during Svalbard cruise KV-Sval1501
, 2018 Shipborne visual observations of Arctic sea ice during Svalbard cruise KV ...
Spreen, Gunnar, Gunnar Spreen (5234729)
core +1 more source