Results 91 to 100 of about 162,083 (309)

Arctic sea-ice decline archived by multicentury annual-resolution record from crustose coralline algal proxy [PDF]

, 2013
Northern Hemisphere sea ice has been declining sharply over the past decades and 2012 exhibited the lowest Arctic summer sea-ice cover in historic times.
Adey, W. H., Edinger, E., Fitzhugh, W. W., Halfar, J., Hetzinger, Steffen, Kronz, A.   +5 more
core   +1 more source

Assessment of contemporary satellite sea ice thickness products for Arctic sea ice [PDF]

The Cryosphere, 2018
Abstract. Advances in remote sensing of sea ice over the past two decades have resulted in a wide variety of satellite-derived sea ice thickness data products becoming publicly available. Selecting the most appropriate product is challenging given end user objectives range from incorporating satellite-derived thickness information in operational ...
H. Sallila, S. L. Farrell, J. McCurry, E. Rinne   +3 more
openaire   +4 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The Grounding of an Ice Shelf in the Central Arctic Ocean: A Modeling Experiment [PDF]

, 2003
A numerical ice sheet model was used in a first test towards evaluating the hypothesis that, during a period of large-scale glaciation, an ice shelf emanating from the Barents/Kara Seas grounded across parts of the Lomonosov Ridge to a depth of around ...
Jakobsson, Martin, Paton, Mark, Siegert, M   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Will Arctic sea ice thickness initialization improve seasonal forecast skill? [PDF]

, 2014
Arctic sea ice thickness is thought to be an important predictor of Arctic sea ice extent. However, coupled seasonal forecast systems do not generally use sea ice thickness observations in their initialization and are therefore missing a potentially ...
Bitz, Blanchard-Wrigglesworth, Blanchard-Wrigglesworth, Blanchard-Wrigglesworth, Chevallier, Chevallier, Collins, Day, Doblas-Reyes, Dunstone, E. Hawkins, Eicken, Guemas, Guemas, Holland, J. J. Day, Johns, Jung, Kaleschke, Koenigk, Koenigk, Latif, Laxon, Lindsay, Massonnet, Mathiot, McLaren, Persson, Pohlmann, S. Tietsche, Schröder, Serreze, Shaffrey, Sigmond, Stephenson, Stroeve, Tietsche, Tietsche, Wang, Yang   +39 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Simulated Atmospheric Response to Regional and Pan-Arctic Sea-Ice Loss [PDF]

, 2017
This is the final version of the article. Available from American Meteorological Society via the DOI in this record.The loss of Arctic sea-ice is already having profound environmental, societal and ecological impacts locally.
Screen, JA
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source