Results 91 to 100 of about 2,283,779 (307)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Shipborne visual observations of Arctic sea ice during Louis S. St-Laurent cruise LSL1409

, 2018
Shipborne visual observations of Arctic sea ice during Louis S.
Alek Petty (8022698), Petty, Alek
core   +1 more source

The Arctic-Subarctic sea ice system is entering a seasonal regime: Implications for future Arctic amplification

Scientific Reports, 2017
The loss of Arctic sea ice is a conspicuous example of climate change. Climate models project ice-free conditions during summer this century under realistic emission scenarios, reflecting the increase in seasonality in ice cover.
Thomas W. N. Haine, Torge Martin
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Shipborne visual observations of Arctic sea ice during Lance cruise LA1208

, 2018
Shipborne visual observations of Arctic sea ice during Lance cruise ...
Spreen, Gunnar, Gunnar Spreen (5234729)
core   +1 more source

Enhanced Arctic sea-ice retreat due to pronounced pacificization effect in the Holocene

Communications Earth & Environment
Future climate confronts major challenges due to ongoing Arctic sea-ice retreat. Notably, eventful sea-ice loss in the Holocene appears comparable circumstance, but associated physics remians poorly understood.
Yuying Zhang, Limin Hu, Xun Gong, Xiaotong Xiao, Zhizheng Jia, Yanguang Liu, Jiang Dong, Anatolii S. Astakhov, Alexander Bosin, Yuri Vasilenko, Meixun Zhao, Ruediger Stein, Gerrit Lohmann, Xuefa Shi   +13 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Shipborne visual observations of Arctic sea ice during 50 let Pobedy cruise Pob1706

, 2018
Shipborne visual observations of Arctic sea ice during 50 let Pobedy cruise ...
Farmer, Lauren, Lauren Farmer (8022713)
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Shipborne visual observations of Arctic sea ice during Lance cruise LA1501

, 2018
Shipborne visual observations of Arctic sea ice during Lance cruise ...
Jennifer King (8022686), King, Jennifer
core   +1 more source