Results 101 to 110 of about 162,083 (309)

Predicting September sea ice: Ensemble skill of the SEARCH Sea Ice Outlook 2008–2013 [PDF]

, 2014
Since 2008, the Study of Environmental Arctic Change Sea Ice Outlook has solicited predictions of September sea-ice extent from the Arctic research community.
Bitz, Cecilia M., Blanchard-Wrigglesworth, Edward, Hamilton, Lawrence C., Stroeve, Julienne   +3 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The emergence of a dipole-like mode in Arctic atmospheric circulation conducive to European heat waves

Communications Earth & Environment
Since the 2000s, there has been a marked acceleration in the decline of summer Arctic sea ice, accompanied by an increase in Arctic sea ice variability.
Doo Young Lee, Sang-Wook Yeh, Yong-Han Lee, Wenju Cai, Guojian Wang, Young-Min Yang   +5 more
doaj   +1 more source

Satellite Observation of Sea Ice Concentration Based on Chinese HY-1C/D Data

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The increasingly significant global warming has severely affected the Arctic region. The melting speed of sea ice is accelerating, and its spatial coverage is gradually shrinking, causing a series of ecological problems that cannot be ignored. Therefore,
Li Xu, Yiming Chen, Deyong Sun, Shengqiang Wang, Lijian Shi, Muhammad Bilal, Yongjun Jia, Shuyan Lang, Bin Zou   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Arctic-Subarctic sea ice system is entering a seasonal regime: Implications for future Arctic amplification

Scientific Reports, 2017
The loss of Arctic sea ice is a conspicuous example of climate change. Climate models project ice-free conditions during summer this century under realistic emission scenarios, reflecting the increase in seasonality in ice cover.
Thomas W. N. Haine, Torge Martin
doaj   +1 more source

Consistent and contrasting decadal Arctic sea ice thickness predictions from a highly optimized sea ice model [PDF]

, 2007
[1] Decadal hindcast simulations of Arctic Ocean sea ice thickness made by a modern dynamic-thermodynamic sea ice model and forced independently by both the ERA-40 and NCEP/NCAR reanalysis data sets are compared for the first time.
Arctic Climate Impact Assessment, Bitz, Bromwich, Bromwich, Cavalieri, Comiso, Curry, Daniel L. Feltham, Flato, Fowler, Hibler, Hibler, Hilmer, Hunke, Hunke, Hunke, Jordan, Kalnay, Köberle, Laxon, Lindsay, Liu, Miller, Miller, Parkinson, Parkinson, Paul A. Miller, Perovich, Rigor, Rothrock, Rothrock, Rothrock, Seymour W. Laxon, Simmons, Smith, Stroeve, Thorndike, Vowinckel, Wensnahan, Wilchinsky, Yu, Zhang, Zhang, Zhang, Zhang   +44 more
core   +1 more source

Arctic tides from GPS on sea-ice

Journal of Geodynamics, 2013
Abstract The presence of sea-ice in the Arctic Ocean plays a significant role in the Arctic climate. Sea-ice dampens the ocean tide amplitude with the result that global tidal models perform less accurately in the polar regions. This paper presents, a kinematic processing of global positioning system (GPS) placed on sea-ice, at six different sites ...
Kildegaard Rose, Stine, Skourup, Henriette, Forsberg, René   +2 more
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Enhanced Arctic sea-ice retreat due to pronounced pacificization effect in the Holocene

Communications Earth & Environment
Future climate confronts major challenges due to ongoing Arctic sea-ice retreat. Notably, eventful sea-ice loss in the Holocene appears comparable circumstance, but associated physics remians poorly understood.
Yuying Zhang, Limin Hu, Xun Gong, Xiaotong Xiao, Zhizheng Jia, Yanguang Liu, Jiang Dong, Anatolii S. Astakhov, Alexander Bosin, Yuri Vasilenko, Meixun Zhao, Ruediger Stein, Gerrit Lohmann, Xuefa Shi   +13 more
doaj   +1 more source