Results 101 to 110 of about 13,364 (264)

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Assimilating Summer Sea‐Ice Thickness Observations Improves Arctic Sea‐Ice Forecast

Geophysical Research Letters
Accurate Arctic sea‐ice forecasting for the melt season is still a major challenge because of the lack of reliable pan‐Arctic summer sea‐ice thickness (SIT) data.
Ruizhe Song, Longjiang Mu, Svetlana N. Loza, Frank Kauker, Xianyao Chen   +4 more
doaj   +1 more source

Passive microwave Arctic sea ice melt onset dates from the advanced horizontal range algorithm 1979-2022. [PDF]

Sci Data, 2023
Bliss AC.
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Long- and short-term variability of Arctic sea-ice cover during the Last Interglacial and Marine Isotope Stage 11c

Communications Earth & Environment
Sea-ice-free Arctic summers are expected within the next decades due to anthropogenic warming. Studying past warm interglacials offers valuable insights into the Arctic climate system under similar conditions. Here we present a series of simulations that
Brian R. Crow, Matthias Prange
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Bathymetry-constrained ocean geostrophic currents play a key role in shaping the sea ice circulation in the Canada Basin, Arctic Ocean

Environmental Research Letters
Satellite-based observations and a pan-Arctic coupled sea ice-ocean model are utilized to study the effect of ocean geostrophic currents on large-scale sea ice circulation in the Canada Basin, Arctic Ocean.
Hengling Leng, Hailun He, Dake Chen, Peigen Lin, Yang Yang, Zhaomin Wang   +5 more
doaj   +1 more source

Continuous observations of the surface energy budget and meteorology over the Arctic sea ice during MOSAiC. [PDF]

Sci Data, 2023
Cox CJ, Gallagher MR, Shupe MD, Persson POG, Solomon A, Fairall CW, Ayers T, Blomquist B, Brooks IM, Costa D, Grachev A, Gottas D, Hutchings JK, Kutchenreiter M, Leach J, Morris SM, Morris V, Osborn J, Pezoa S, Preußer A, Riihimaki LD, Uttal T.   +21 more
europepmc   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Unprecedented decline of Arctic sea ice outflow in 2018. [PDF]

Nat Commun, 2022
Sumata H, de Steur L, Gerland S, Divine DV, Pavlova O.   +4 more
europepmc   +1 more source