Results 101 to 110 of about 2,283,779 (307)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Shipborne visual observations of Arctic sea ice during Lance cruise LA1508
, 2018 Shipborne visual observations of Arctic sea ice during Lance cruise ...
Anja Rösel (8022689), Rösel, Anja
core +1 more source
Modern dirty sea ice characteristics and sources : The role of anchor ice [PDF]
, 2011 Extensive dirty ice patches with up to 7 kg m−2 sediment concentrations in layers of up to 10 cm thickness were encountered in 2005 and 2007 in numerous areas across the central Arctic.
Jakobsson, Martin, +12 more
core +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Shipborne visual observations of Arctic sea ice during 50 let Pobedy cruise Pob1507
, 2018 Shipborne visual observations of Arctic sea ice during 50 let Pobedy cruise ...
Cowan, Alex, Alex Cowan (8022707)
core +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
, 2015 Sea-ice concentration and under-ice water parameters from the Eurasian central Arctic Ocean during August-September ...
Peeken, Ilka +9 more
core +1 more source
Enhancing sea ice knowledge through assimilation of sea ice thickness from ENVISAT and CS2SMOS [PDF]
The CryosphereArctic sea ice extent has declined significantly over the past four decades, opening up the Arctic to shipping and resource extraction while also impacting wildlife and local communities.
N. Williams +3 more
doaj +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source