Results 81 to 90 of about 162,083 (309)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Changes in the Arctic Traffic Occupancy and Their Connection to Sea Ice Conditions from 2015 to 2020

Remote Sensing
Arctic shipping activities are increasing in the context of sea ice decline. However, research gaps persist in studying recent Arctic shipping activities across various vessel types and their connection with sea ice conditions.
Yihan Liu, Hao Luo, Chao Min, Qiong Chen, Qinghua Yang   +4 more
doaj   +1 more source

Status and trends in the structure of Arctic benthic food webs [PDF]

Polar Research, 2015
Ongoing climate warming is causing a dramatic loss of sea ice in the Arctic Ocean, and it is projected that the Arctic Ocean will become seasonally ice-free by 2040.
Monika Kędra, Charlotte Moritz, Emily S. Choy, Carmen David, Renate Degen, Steven Duerksen, Ingrid Ellingsen, Barbara Górska, Jacqueline M. Grebmeier, Dubrava Kirievskaya, Dick van Oevelen, Kasia Piwosz, Annette Samuelsen, Jan Marcin Węsławski   +13 more
doaj   +1 more source

Radiative Heating of an Ice-Free Arctic Ocean [PDF]

, 2019
During recent decades, there has been dramatic Arctic sea ice retreat. This has reduced the top-of-atmosphere albedo, adding more solar energy to the climate system.
Eisenman, I, Pistone, K, Ramanathan, V
core   +1 more source

Dramatic interannual changes of perennial Arctic sea ice linked to abnormal summer storm activity [PDF]

, 2013
Copyright © 2011 American Geophysical UnionThe perennial (September) Arctic sea ice cover exhibits large interannual variability, with changes of over a million square kilometers from one year to the next.
Asplin, Boé, Brümmer, Brümmer, Comiso, Deser, Eastman, Fowler, Francis, Graversen, Hakkinen, Ian Simmonds, Intrieri, James A. Screen, Kay, Kevin Keay, Lindsay, Lukovich, Maslanik, McCabe, Murray, Ogi, Ogi, Onogi, Perovich, Pinto, Raible, Rayner, Rossow, Schweiger, Screen, Screen, Screen, Screen, Sepp, Serreze, Serreze, Serreze, Simmonds, Simmonds, Sorteberg, Sorteberg, Stroeve, Tsukernik, Wang, Wang, Woodgate, Zhang   +47 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Shipping Through Sea Ice: Impacts on Marine Habitats and Best Practices [PDF]

, 2017
As the result of Arctic climate change and an increase in shipping season length, there is a growing interest in Arctic shipping operations. Sea ice serves as an important habitat for marine mammals, therefore, shipping through sea ice could lead to ...

core  

Weakening of the stratospheric polar vortex by Arctic sea-ice loss [PDF]

Successive cold winters of severely low temperatures in recent years have had critical social and economic impacts on the mid-latitude continents in the Northern Hemisphere.
Jeong, JH, Kim, BM, Kim, SJ, Min, SK, Shim, T, Son, SW, Yoon, JH, Zhang, XD   +7 more
core   +1 more source

Sea-ice dynamics in an Arctic coastal polynya during the past 6500 years [PDF]

, 2016
The production of high-salinity brines during sea-ice freezing in circum-arctic coastal polynyas is thought to be part of northern deep water formation as it supplies additional dense waters to the Atlantic meridional overturning circulation system.
A Mackensen, A Navarro-Rodriguez, BM Vinther, C Reimann, D Quadfasel, D Winkelmann, DH Loring, DH Loring, DJ Cavalieri, H Eicken, H Jensen, H Renssen, HA Bauch, I Hall, J Haarpaintner, J Laskar, J Müller, JA Hölemann, JH Jungclaus, K Aagaard, K Aagaard, K Werner, K Werner, K Werner, KA Sullivan, KJ Wedepohl, KP Jochum, L Vare, M Alonso-Garcia, M Blaschek, M Forwick, M Reigstad, M Sarnthein, M Stuiver, M Årthun, MM Telesiński, MM Telesiński, P Cabedo-Sanz, PD Killworth, PJ Reimer, R Skogseth, RF Spielhagen, RT Ottesen, S Belt, S Belt, S Rahmstorf, ST Belt, ST Belt, T Tamura, TA Brown, TL Rasmussen, TL Rasmussen, TL Rasmussen, TM Dokken, U Schauer, WJ D’Andrea, WS Broecker, X Xiao   +57 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source