Results 61 to 70 of about 2,194,928 (297)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Spatiotemporal Variation Characteristics and Drivers of Winter Arctic Sea Ice Thickness Under the New Arctic Regime

Journal of Marine Science and Engineering
The “New Arctic” regime represents a prominent climatic feature of the Arctic Ocean under global warming, characterized by persistently low summer sea ice extent, a marked reduction in sea ice thickness, and an expansion of open water areas at high ...
Yaowei Yin, Xiaoyu Wang
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Tropical ocean-atmosphere controls on inter-annual climate variability in the Cretaceous Arctic

, 2011
The first annually resolved sedimentary record from the Cretaceous is used to develop time series of inter-annual and decadal scale climate variability from the Arctic Ocean.
Kemp, Alan E.S., Heiko Pälike, Davies, Andrew, Pälike, Heiko, Alan E. S. Kemp, Andrew Davies   +5 more
core   +1 more source

Modeled Arctic sea ice evolution through 2300 in CMIP5 extended RCPs [PDF]

The Cryosphere, 2014
Almost all global climate models and Earth system models that participated in the Coupled Model Intercomparison Project 5 (CMIP5) show strong declines in Arctic sea ice extent and volume under the highest forcing scenario of the representative ...
P. J. Hezel, T. Fichefet, F. Massonnet
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Impact of atmospheric rivers on Arctic sea ice variations [PDF]

The Cryosphere
Arctic sea ice has been declining rapidly in recent decades. We investigate how the poleward transport of moisture and heat from lower latitudes through atmospheric rivers (ARs) influences Arctic sea ice variations.
L. Li, F. Cannon, M. R. Mazloff, A. C. Subramanian, A. M. Wilson, F. M. Ralph   +5 more
doaj   +1 more source

Less Surface Sea Ice Melt in the CESM2 Improves Arctic Sea Ice Simulation With Minimal Non‐Polar Climate Impacts

Journal of Advances in Modeling Earth Systems, 2022
This study isolates the influence of sea ice mean state on pre‐industrial climate and transient 1850–2100 climate change within a fully coupled global model: The Community Earth System Model version 2 (CESM2).
Jennifer E. Kay, Patricia DeRepentigny, Marika M. Holland, David A. Bailey, Alice K. DuVivier, Ed Blanchard‐Wrigglesworth, Clara Deser, Alexandra Jahn, Hansi Singh, Madison M. Smith, Melinda A. Webster, Jim Edwards, Sun‐Seon Lee, Keith B. Rodgers, Nan Rosenbloom   +14 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source