Results 61 to 70 of about 2,283,779 (307)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Impact of atmospheric rivers on Arctic sea ice variations [PDF]

The Cryosphere
Arctic sea ice has been declining rapidly in recent decades. We investigate how the poleward transport of moisture and heat from lower latitudes through atmospheric rivers (ARs) influences Arctic sea ice variations.
L. Li, F. Cannon, M. R. Mazloff, A. C. Subramanian, A. M. Wilson, F. M. Ralph   +5 more
doaj   +1 more source

Less Surface Sea Ice Melt in the CESM2 Improves Arctic Sea Ice Simulation With Minimal Non‐Polar Climate Impacts

Journal of Advances in Modeling Earth Systems, 2022
This study isolates the influence of sea ice mean state on pre‐industrial climate and transient 1850–2100 climate change within a fully coupled global model: The Community Earth System Model version 2 (CESM2).
Jennifer E. Kay, Patricia DeRepentigny, Marika M. Holland, David A. Bailey, Alice K. DuVivier, Ed Blanchard‐Wrigglesworth, Clara Deser, Alexandra Jahn, Hansi Singh, Madison M. Smith, Melinda A. Webster, Jim Edwards, Sun‐Seon Lee, Keith B. Rodgers, Nan Rosenbloom   +14 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Changes in shelf waters due to air-sea fluxes and their influence on the Arctic Ocean circulation as simulated in the OCCAM global ocean model

, 2005
In this study we look at the ocean circulation of the Arctic Ocean in the high-resolution OCCAM global ocean model. The Arctic Ocean consists of deep basins surrounded by a large area of continental shelves, where cooling and ice formation play an ...
Levine, R.C.
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tropical ocean-atmosphere controls on inter-annual climate variability in the Cretaceous Arctic

, 2011
The first annually resolved sedimentary record from the Cretaceous is used to develop time series of inter-annual and decadal scale climate variability from the Arctic Ocean.
Kemp, Alan E.S., Heiko Pälike, Davies, Andrew, Pälike, Heiko, Alan E. S. Kemp, Andrew Davies   +5 more
core   +1 more source

Changes in the Arctic Traffic Occupancy and Their Connection to Sea Ice Conditions from 2015 to 2020

Remote Sensing
Arctic shipping activities are increasing in the context of sea ice decline. However, research gaps persist in studying recent Arctic shipping activities across various vessel types and their connection with sea ice conditions.
Yihan Liu, Hao Luo, Chao Min, Qiong Chen, Qinghua Yang   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source