Results 61 to 70 of about 32,514 (263)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Growth and motion at the Weddell Sea ice edge

, 2007
The formation of sea ice in the presence of turbulence was studied using data from drifting buoydeployments and ice sampling in the Weddell Sea during April 2000.
Doble, Martin Jonathan
core  

Atmospheric Conditions Preceeding Very Rapid Sea Ice Loss Events [PDF]

, 2019
Even though the observed amplified warming trend in the Arctic region is well-established in theory through climate feedbacks and reproduced in global climate model projections, the same global climate models underestimate the corresponding decline in ...
Frank, Madeline Clark
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Changes in shelf waters due to air-sea fluxes and their influence on the Arctic Ocean circulation as simulated in the OCCAM global ocean model

, 2005
In this study we look at the ocean circulation of the Arctic Ocean in the high-resolution OCCAM global ocean model. The Arctic Ocean consists of deep basins surrounded by a large area of continental shelves, where cooling and ice formation play an ...
Levine, R.C.
core  

Shipborne visual observations of Arctic sea ice during Arctic Sunrise cruise ArcSun1209

, 2018
Shipborne visual observations of Arctic sea ice during Arctic Sunrise cruise ...
Stroeve, Julienne C, Julienne C Stroeve (8022683)   +1 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Sources of Organic and Inorganic Halogens to the Polar and Temperate Marine Boundary Layer [PDF]

, 2011
Very short lived halogenated substances (VSLH) are of importance for the transport of reactive halogens to the troposphere and lower stratosphere, whereas molecular halogens are of specific importance to the Marine Boundary Layer (MBL).
Shaw, M
core  

Assessing sea ice trafficability in a changing arctic [PDF]

, 2018
Arctic sea ice has undergone rapid changes during the last few decades, with negative implications for over-ice travel and on-ice operations, which benefit from services provided by the sea ice.
Mahoney, Andrew R., Sarah Betcher, Dammann, Dyre O., Mahoney, Andrew R.,, Meyer, Franz J.,, Dyre O. Dammann, Eicken, Hajo,, Meyer, Franz J., Eicken, Hajo, Betcher, Sarah, Franz J. Meyer, Hajo Eicken, Betcher, Sarah,, Dammann, Dyre Oliver,, Dammann, Dyre Oliver, Andrew R. Mahoney   +15 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source