Results 71 to 80 of about 306,735 (293)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Arctic Offshore Oil and Gas Guidelines [PDF]
, 2009 The Ministers of the Arctic States—Canada, Denmark, Iceland, Finland, Russia, Sweden, Norway and the United States of America— originally adopted the Guidelines at the Fourth Ministerial Conference on the Protection of the Arctic Environment, 11-12 June,
Arctic Council, Protection of the Arctic Marine Environment (PAME)
core +1 more source
Recent Eurasian winter temperature change and its association with Arctic sea-ice loss
Polar Research, 2020 The surface air temperature in the northern mid-latitudes during winter showed a significant cooling trend from the late 1990s to the early 2010s, in spite of increasing greenhouse gas concentrations.
Hye-Jin Kim, Seok-Woo Son
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Drivers of Changing Interannual Variability in Autumn‐Early Winter Arctic Sea Ice (1950–2024)
Geophysical Research LettersArctic sea ice has undergone a pronounced decline over recent decades, yet the drivers of its interannual variability remains unclear. Here we utilize standard deviation to assess long‐term changes in autumn‐early winter (October–December) Arctic sea ice
Lejiang Yu, Shiyuan Zhong, Timo Vihma
doaj +1 more source
The Arctic Council Iqaluit 1998 Ministerial Meeting [PDF]
, 1998 The Ministerial Declaration from the 1st Arctic Council Ministerial Meeting in Iqaluit, 18 September ...
Arctic Council, -
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Arctic Environmental Protection Strategy (AEPS) Ministerial Meeting in Alta, Norway. 1997 [PDF]
, 1997 Arctic Environmental Protection Strategy (AEPS) is the predecessor of the Arctic Council, established in Rovaniemi Finland in 1991.
Arctic Council, -
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source