Results 81 to 90 of about 333,091 (340)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Two distinct declining trend of autumn Arctic sea ice concentration before and after 2002
Environmental Research CommunicationsThis study investigates the Arctic sea ice concentration trend during 1979–2021 and explores why the autumn Arctic sea ice loss is accelerated after 2002 and its trend declining center shifts from the Chukchi Sea to the Barents-Kara-Laptev Seas ...
Yijiao Li +4 more
doaj +1 more source
Overview of the Nordic Seas CARINA data and salinity measurements [PDF]
Earth System Science Data, 2009 Water column data of carbon and carbon relevant hydrographic and hydrochemical parameters from 188 previously non-publicly available cruises in the Arctic, Atlantic, and Southern Ocean have been retrieved and merged into a new database: CARINA (CARbon IN
A. Olsen +21 more
doaj
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
The Arctic Council Iqaluit 1998 Ministerial Meeting [PDF]
, 1998 The Ministerial Declaration from the 1st Arctic Council Ministerial Meeting in Iqaluit, 18 September ...
Arctic Council, -
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Declaration on the Establishment of the Arctic Council 1996 - Ottawa Declaration. [PDF]
, 1996 Declaration on the Establishment of the Arctic Council - Joint Communique of the Governments of the Arctic Countries on the Establishment of the Arctic Council.
Arctic Council, -
core +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Recent Eurasian winter temperature change and its association with Arctic sea-ice loss
Polar Research, 2020 The surface air temperature in the northern mid-latitudes during winter showed a significant cooling trend from the late 1990s to the early 2010s, in spite of increasing greenhouse gas concentrations.
Hye-Jin Kim, Seok-Woo Son
doaj +1 more source