Results 281 to 290 of about 599,754 (328)

Advances in appetite regulation by the arcuate nucleus

Nature Reviews Endocrinology
In 2024, new insights identified a cluster of leptin-targeted neurons and integrative networks that link sensory inputs (heat and food perception) with feeding centres and peripheral systems. Key findings revealed hypothalamic site-specific adaptive mechanisms, in which nutritional state-dependent remodelling of extracellular compounds and neuropeptide
C. García-Cáceres
openaire   +4 more sources

Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

Science, 2004
The fat-derived hormone leptin regulates energy balance in part by modulating the activity of neuropeptide Y and proopiomelanocortin neurons in the hypothalamic arcuate nucleus. To study the intrinsic activity of these neurons and their responses to leptin, we generated mice that express distinct green fluorescent proteins in these two ...
Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, Cai X, Friedman JM, Horvath TL   +7 more
openaire   +4 more sources

Anatomy and physiology of the neuroendocrine arcuate nucleus

Peptides, 1985
The arcuate nucleus surrounds the ventral part of the third ventricle and contains densely packed small neurons with 1-3 dendrites. At least fifteen transmitters and neuropeptides have been found in perikarya of arcuate neurons. Each transmitter and neuropeptide have a characteristic distribution.
openaire   +4 more sources

Adrenalectomy decreases neuropeptide Y mRNA levels in the arcuate nucleus

Brain Research Bulletin, 1990
Recent studies suggest that glucocorticoids may increase NPY and NPY mRNA levels. To determine if endogenous corticosterone affects the level of NPY mRNA in areas that control NPY levels in the paraventricular nucleus, we examined the effects of adrenalectomy and corticosterone replacement on NPY mRNA levels in the arcuate nucleus and brainstem.
B D, White, R G, Dean, R J, Martin
openaire   +4 more sources

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Nature, 2001
M. Cowley, James L. Smart, M. Rubinstein, Marcelo G. Cerdán, S. Diano, T. Horvath, R. Cone, M. Low   +7 more
semanticscholar   +3 more sources

AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity.

European Journal of Pharmacology, 2021
Obesity is a major health crisis affecting over a third of the global population. This multifactorial disease is regulated via interoceptive neural circuits in the brain, whose alteration results in excessive body weight.
Muhammad Sufyan Vohra, Khaled Benchoula, C. Serpell, Wong Eng Hwa   +3 more
semanticscholar   +1 more source

Arcuate nucleus, median eminence, and hypophysial pars tuberalis

2021
The arcuate nucleus (ARC) is located in the mediobasal hypothalamus and forms a morphological and functional entity with the median eminence (ME), the ARC-ME. The ARC comprises several distinct types of neurons controlling prolactin release, food intake, and metabolism as well as reproduction and onset of puberty. The ME lacks a blood-brain barrier and
Korf, Horst Werner, Møller, Morten
openaire   +3 more sources

β-Carbolines in rat arcuate nucleus

Neuroscience, 1978
Abstract The arcuate nucleus of the rat exhibits a brilliant yellow-green fluorescence when irradiated in situ with a He-Cd ultraviolet laser microfluorimeter employing 325 nm incident light. Fluorescent emission spectra demonstrated peaks at 445 nm, 470 nm and 520 nm. The latter peak undergoes rapid photodecomposition.
D W, Shoemaker, J T, Cummins, T G, Bidder   +2 more
openaire   +2 more sources

Central leptin signalling: Beyond the arcuate nucleus

Autonomic Neuroscience, 2010
Leptin is an adipocyte-derived hormone that plays a crucial role in the maintenance of energy balance. Work over the past 15 years has led to a detailed understanding of its signalling and sites of action, particularly its activation of the central melanocortin signalling pathway through the arcuate nucleus of the hypothalamus (ARC).
Jovanovic, Zorica, Yeo, Giles S.H.
openaire   +2 more sources