Results 101 to 110 of about 27,832 (229)

Sustained diabetes remission induced by FGF1 involves a shift in transcriptionally distinct AgRP neuron subpopulations

Molecular Metabolism
In rodent models of type 2 diabetes, a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) induces sustained remission of hyperglycemia. Overactive agouti-related peptide (AgRP) neurons, located in the hypothalamic arcuate
Nadia N. Aalling, Petar V. Todorov, Shad Hassan, Dylan M. Belmont-Rausch, Oliver Pugerup Christensen, Claes Ottzen Laurentiussen, Anja M. Jørgensen, Kimberly M. Alonge, Jarrad M. Scarlett, Zaman Mirzadeh, Jenny M. Brown, Michael W. Schwartz, Tune H. Pers   +12 more
doaj   +1 more source

Leptin is required for hypothalamic regulation of miRNAs targeting POMC 3 ′ UTR [PDF]

, 2015
International audienceThe central nervous system (CNS) monitors modifications in metabolic parameters or hormone levels and elicits adaptive responses such as food intake regulation. Particularly, within the hypothalamus, leptin modulates the activity of
Adel Derghal, Bagga, Benoit, Berglund, Bruno Bariohay, Catherine Tardivel, Ceddia, Chen, Chiang, Clément Pierre, Coraline Airault, Cowley, Crépin, Gao, Girardet, Greenman, Herzer, Hill, Huszar, Ibrahim, Jean-Denis Troadec, Jérôme Trouslard, Lee, Li, Lourdes Mounien, Lovis, Margetic, Mehdi Djelloul, Michel Dallaporta, Mizuno, Morton, Mounien, Mounien, Mounien, Mounien, Mounien, Nakanishi, Nilaweera, Ollmann, Parton, Pinto, Plum, Porte, Poy, Sangiao-Alvarellos, Schneeberger, Smith, Tattikota, Thompson, Vanessa Tillement, Williams, Xie, Yaswen   +52 more
core   +4 more sources

Natural Products as the Modulators of Gut Microbiota: A Pool for the Development of New Treatment Against Obesity?

Food Frontiers, Volume 7, Issue 3, May 2026.
Natural compounds regulate gut microbiota by improving microbial balance and increasing probiotics, which boost short‐chain fatty acid production to alleviate insulin resistance and inflammation. Additionally, they stimulate appetite‐suppressing hormones through bile acid signaling, while inhibiting pathogenic bacteria to repair intestinal barrier ...
Hongchao Yuan, Yau‐Yuen Chan, Guang Chen, Lin Xu, Cheng Zhang, Guoyi Tang, Yibin Feng, Ning Wang   +7 more
wiley   +1 more source

Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes—A Cautionary Tale

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
Two strategies were used to target BMPR1A in adult hypothalamic tanycytes: (1) inducible Rax‐CreERT2 and (2) AAV‐Dio2‐iCre–mediated recombination. Although robust expression of reporter fluorescence and recombination gel analysis confirmed Cre activity in both models, BMPR1A expression was not reduced in targeted tanycytes.
Tianyi Tao, Noelle Leon‐Palmer, Sabrina DiPietro, Kristy L. Townsend   +3 more
wiley   +1 more source

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Systemic Glucose Administration Alters Water Diffusion and Microvascular Blood Flow in Mouse Hypothalamic Nuclei – An fMRI Study

Frontiers in Neuroscience, 2019
The hypothalamus is the principal regulator of global energy balance, enclosing additionally essential neuronal centers for glucose-sensing and osmoregulation.
Blanca Lizarbe, Antonio Fernández-Pérez, Antonio Fernández-Pérez, Victor Caz, Carlota Largo, Mario Vallejo, Mario Vallejo, Pilar López-Larrubia, Sebastián Cerdán   +8 more
doaj   +1 more source

CNS Control of Glucose Metabolism: Response to Environmental Challenges [PDF]

, 2013
Over the last 15 years, considerable work has accumulated to support the role of the CNS in regulating postprandial glucose levels. As discussed in the first section of this review, the CNS receives and integrates information from afferent neurons ...
Arble, Deanna M., Sandoval, Darleen A.
core   +1 more source

Central Regulation of Pituitary-Thyroid Axis Under Physiological and Pathophysiological Conditions. [PDF]

, 2014
TRH is a tripeptide amide that functions as a neurotransmitter but also serves as a neurohormone that has a critical role in the central regulation of the hypothalamic-pituitary-thyroid axis.
Fekete, Csaba, Lechan, RM.
core   +1 more source

Anatomical Description of the Main Gyri and Sulci of the Telencephalon of Alouatta belzebul

Anatomia, Histologia, Embryologia, Volume 55, Issue 3, May 2026.
ABSTRACT The Alouatta belzebul is a species of howler monkey, of the Atelidae family and genus Alouatta. It is endemic in Brazil and has a separate geographic distribution, with two populations occurring: in the Amazon and in the Atlantic Forest on the coast of Northeast Brazil. The species is classified as ‘vulnerable’, and this is mainly justified by
Dayane Kelly Sabec Pereira, Fabiano Rodrigues de Melo, Fabiana Cristina Silveira Alves de Melo, Kleber Fernando Pereira, Valcinir Aloisio Scalla Vulcani   +4 more
wiley   +1 more source

Impact of birth weight and gender on early postnatal hypothalamic energy balance regulatory gene expression in the young lamb [PDF]

, 2013
Peer ...
Adam, C. L., Aitken, R. P., Bake, T., Findlay, P. A., Milne, J. S., Wallace, J. M.   +5 more
core   +1 more source