Results 111 to 120 of about 27,832 (229)

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors

Cell Reports, 2015
It is well recognized that feeding behavior in mammals is orchestrated by neurons within the medial basal hypothalamus. However, it remains unclear whether food intake is also under the control of glial cells.
Liang Yang, Yong Qi, Yunlei Yang
doaj   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, Volume 183, Issue 9, Page 2139-2165, May 2026.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity

Disease Models & Mechanisms, 2017
The ‘obesity epidemic’ represents a major global socioeconomic burden that urgently calls for a better understanding of the underlying causes of increased weight gain and its associated metabolic comorbidities, such as type 2 diabetes mellitus and ...
Katharina Timper, Jens C. Brüning
doaj   +1 more source

Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis [PDF]

, 2007
The initiation of mammalian puberty and the maintenance of female reproductive cycles are events controlled by hypothalamic neurons that secrete the decapeptide gonadotropin-releasing hormone (GnRH).
Sabine Heger, Claudio Mastronardi, Gregory A. Dissen, Alejandro Lomniczi, Ricardo Cabrera, Christian L. Roth, Heike Jung, Francesco Galimi, Wolfgang Sippell, Sergio R. Ojeda, Ojeda, Terasawa, Dungan, DeFazio, Krewson, Seminara, Palmert, de Vries, Ojeda, Davidson, Basso, Rampazzo, Sutton, Martin, Bhanot, Ebling, Morris-Desbois, Burkhard, Sauring, Freemont, Waterman, Bridge, Tiscornia, Sledz, Simerly, Farooqi, Ahima, Shimono, Childs, Treacy, Ma, Ojeda, Kimura, Lee, Mastronardi, Ojeda, Watanabe, Nelson, Prevot, Dissen, Dissen, Shahab, Miyagishi, Singer, Chen, Naldini, Kootstra   +56 more
core   +1 more source

Plasticity of the melanocortin system: determinants and possible consequences on food intake

Frontiers in Endocrinology, 2015
The melanocortin system is one of the most important neuronal pathways involved in the regulation of food intake and is probably the best characterized.
Danaé eNuzzaci, Amélie eLaderrière, Aleth eLemoine, Emmanuelle eNédélec, Luc ePénicaud, Caroline eRigault, Alexandre eBenani   +6 more
doaj   +1 more source

Vagal Blocking for Obesity Control : a Possible Mechanism-Of-Action [PDF]

, 2016
14 September 2016 Erratum to: Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action Helene Johannessen, David Revesz, Yosuke Kodama, Nikki Cassie, Karolina P Skibicka, Perry Barrett, Suzanne Dickson, Jens Holst, Jens Rehfeld, Geoffrey van ...
Adan, Roger, Barrett, Perry, Ben-Menachem, Elinor, Cassie, Nikki, Chen, Duan, Dickson, Suzanne, Holst, Jens, Johannessen, Helene, Kodama, Yosuke, Kulseng, Bård, Rehfeld, Jens, Revesz, David, Skibicka, Karolina P, van der Plasse, Geoffrey, Zhao, Chun-Mei   +14 more
core   +1 more source

Vulnerability of mitochondrial OXPHOS complexes in the arcuate nucleus of the hypothalamus of Alzheimer's disease

Journal of Alzheimer’s Disease
Background With increasing recognition of the heterogeneity of the etiopathogenesis of Alzheimer's disease (AD), clinical and basic research has accentuated a contribution of hypothalamic dysfunction to the development of this neurodegenerative disorder.
Jing Tian, Sai Sreeja Meka, Tienju Wang, Lan Guo, Heng Du   +4 more
openaire   +2 more sources

Knocking down the neuronal lactate transporter MCT2 in the arcuate nucleus of female rats increases food intake and body weight

Scientific Reports
In the arcuate nucleus of the hypothalamus, tanycyte-neuron interactions regulate glucose homeostasis and feeding behavior. Previously, we reported that monocarboxylate transporters (MCT) 1 and 4 are localized in tanycytes, whereas MCT2 is present in ...
Alanis Coca, Sergio López, Patricio Órdenes, Vania Sepúlveda, Diego Cuevas, Andrés Villarroel, Javiera Álvarez-Indo, Patricia V. Burgos, Estefanía Tarifeño, Roberto Elizondo-Vega, María A García-Robles   +10 more
doaj   +1 more source

Efferent projections of C3 adrenergic neurons in the rat central nervous system [PDF]

, 2012
C3 neurons constitute one of three known adrenergic nuclei in the rat central nervous system (CNS). While the adrenergic C1 cell group has been extensively characterized both physiologically and anatomically, the C3 nucleus has remained relatively ...
Allen, Andrew M., Anderson, Colin R., Bassi, Jaspreet, Sevigny, Charles P., Thomas, Walter G., Williams, David A.   +5 more
core   +1 more source