Results 111 to 120 of about 23,715 (250)

Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors

Cell Reports, 2015
It is well recognized that feeding behavior in mammals is orchestrated by neurons within the medial basal hypothalamus. However, it remains unclear whether food intake is also under the control of glial cells.
Liang Yang, Yong Qi, Yunlei Yang
doaj   +1 more source

Ingestão de alimento após a ativação de receptores 5-HT1A do núcleo arqueado do hipotálamo e da área hipotalâmica lateral de ratas em duas fases do ciclo estral [PDF]

, 2009
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2009.O presente estudo examinou os efeitos da injeção local de metergolina (MET, antagonista de ...
Steffens, Sérgio Murilo
core  

5-ht inhibition of rat insulin 2 promoter cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus [PDF]

, 2009
A number of anti-obesity agents have been developed that enhance hypothalamic 5-HT transmission. Various studies have demonstrated that arcuate neurons, which express proopiomelanocortin peptides (POMC neurons), and neuropeptide Y with agouti-related ...
Smith, M. A., Ashford, M. L. J.; id_orcid, Ashford, M.L.J., Hisadome, K., Withers, D.J., Withers, D. J., Choudhury, A.I., Smith, M.A., Claret, M., Choudhury, A. I.   +9 more
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Knocking down the neuronal lactate transporter MCT2 in the arcuate nucleus of female rats increases food intake and body weight

Scientific Reports
In the arcuate nucleus of the hypothalamus, tanycyte-neuron interactions regulate glucose homeostasis and feeding behavior. Previously, we reported that monocarboxylate transporters (MCT) 1 and 4 are localized in tanycytes, whereas MCT2 is present in ...
Alanis Coca, Sergio López, Patricio Órdenes, Vania Sepúlveda, Diego Cuevas, Andrés Villarroel, Javiera Álvarez-Indo, Patricia V. Burgos, Estefanía Tarifeño, Roberto Elizondo-Vega, María A García-Robles   +10 more
doaj   +1 more source

Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity

Disease Models & Mechanisms, 2017
The ‘obesity epidemic’ represents a major global socioeconomic burden that urgently calls for a better understanding of the underlying causes of increased weight gain and its associated metabolic comorbidities, such as type 2 diabetes mellitus and ...
Katharina Timper, Jens C. Brüning
doaj   +1 more source

A secretagogin locus of the mammalian hypothalamus controls stress hormone release

, 2015
This work was supported by the Swedish Research Council (T.Ha., T.Hö.), Hjärnfonden (T.Ha.), the Petrus and Augusta Hedlunds Foundation (T.Ha., T.Hö.), the Novo Nordisk Foundation (T.Ha., T.Hö.), Karolinska Institutet (T.Hö.), the Medical University of ...
Marc Landry, Alpár, Alán, Robert Schnell, Botting, Catherine H., André Calas, Shirran, Sally Lorna, Miklós Palkovits, Fuszard, Matthew Alexander, Wagner, Ludwig, Fuszard, Matthew, Zhang, Ming-Dong, Árpád Dobolyi, Jan Mulder, Catherine H Botting, Sten Linnarsson, Tibor Harkany, Lauren Spence, Spence, Lauren, Harkany, Tibor, Sally L Shirran, Matthew Fuszard, Uhlen, Mathias, Hökfelt, Tomas, Landry, Marc, Shirran, Sally L., Martens, Henrik, Amit Zeisel, Mathias Uhlen, Romanov, Roman A., Botting, Catherine Helen, Tomas Hökfelt, Calas, André, Oláh, Márk, Alán Alpár, Harald H Sitte, Linnarsson, Sten, Márk Oláh, Henrik Martens, Roman A Romanov, Schnell, Robert, Ming‐Dong Zhang, Ludwig Wagner, Sitte, Harald H., Uhlén, Mathias,, Dobolyi, Árpád, Zeisel, Amit, Mulder, Jan, Palkovits, Miklós   +47 more
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Plasticity of the melanocortin system: determinants and possible consequences on food intake

Frontiers in Endocrinology, 2015
The melanocortin system is one of the most important neuronal pathways involved in the regulation of food intake and is probably the best characterized.
Danaé eNuzzaci, Amélie eLaderrière, Aleth eLemoine, Emmanuelle eNédélec, Luc ePénicaud, Caroline eRigault, Alexandre eBenani   +6 more
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Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus

, 1998
The adipose tissue-derived hormone leptin regulates body weight homeostasis by decreasing food intake and increasing energy expenditure. The weight-reducing action of leptin is thought to be mediated primarily by signal transduction through the leptin ...
Brown, H, Nico Ghilardi, Marie-Louise Håkansson, Håkansson, ML, Skoda, RC, Ghilardi, N, Hilary Brown, Björn Meister, Meister, B,, Radek C. Skoda   +9 more
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Cellular and metabolic function of GIRK1 potassium channels expressed by arcuate POMC and NPY/AgRP neurons

Molecules and Cells
: It is well known that the G protein-gated inwardly rectifying K+ (GIRK) channels are critical to maintain excitability of central neurons. GIRK channels consist of 4 subunits and GIRK1/GIRK2 heterotetramers are considered to be the neuronal prototype ...
Yeeun Choi, Eun-Seon Yoo, Youjin Oh, Jong-Woo Sohn   +3 more
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Effect of hypothyroidism on the hypothalamic–pituitary–ovarian axis and reproductive function of pregnant rats

BMC Endocrine Disorders, 2018
Background This study aimed to detect changes in hormone levels in the hypothalamic–pituitary–ovarian axis in Sprague-Dawley (SD) rats with hypothyroidism, and identify differences in the pregnancy and abortion rates of female adult rats.
Jianran Sun, Cancan Hui, Tongjia Xia, Min Xu, Datong Deng, Faming Pan, Youmin Wang   +6 more
doaj   +1 more source