Results 61 to 70 of about 299,530 (310)

Association Between Ventilatory Settings and Development of Acute Respiratory Distress Syndrome in Mechanically Ventilated Patients Due to Brain Injury [PDF]

, 2017
PURPOSE: In neurologically critically ill patients with mechanical ventilation (MV), the development of acute respiratory distress syndrome (ARDS) is a major contributor to morbidity and mortality, but the role of ventilatory management has been ...
Amin, P, Anzueto, A, Davies, AR, Du, B, Esteban, A, Ferguson, ND, Frutos-Vivar, F, González, M, Hurtado, J, Jibaja, M, Koh, Y, Kuiper, MA, Maggiore, SM, Matamis, D, Moreno, R, Muriel, A, Nin, N, Pelosi, P, Peñuelas, O, Raymondos, K, Rios, F, Soares, MA, Sutherasan, Y, Tejerina, E, Thille, AW, Villagomez, AJ, Violi, DA, Zeggwagh, AA   +27 more
core   +1 more source

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

Advanced Science, EarlyView.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei, Yufan Li, Juan Song, Cuiping Zhang, Xiaoyan Chen, Cuicui Chen, Qingyuan Xu, Xu Wu, Yuanlin Song   +11 more
wiley   +1 more source

Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS) [PDF]

, 2015
Rationale: Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory distress syndrome (ARDS). Causality of these associations has never
A. M. Turner, A. R. Martineau, Amrein, B. Naidu, Bernard, C. R. Bassford, Calfee, Cannell, Chishimba, Craig, D. G. Bartis, D. M. Sansom, D. Parekh, D. Park, D. R. Thickett, E. Sapey, Edelson, Eisner, F. Gao, Flynn, Froicu, G. D. Perkins, Grant, Hewison, Holick, K. B. Christopher, Kempker, Lax, Leow, M. S. Cooper, Mohamed, Nathani, O'Kane, P. M. Stewart, Parekh, Parekh, Parekh, Perkins, Perkins, Perkins, R. C. A. Dancer, R. Mahida, Remmelts, S. Lax, S. Zheng, Takano, Thomas, V. D'Souza, van Schoor, W. D. Fraser, W. Wei, Ware   +51 more
core   +4 more sources

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, EarlyView.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source

Lung ultrasound may be a valuable aid in decision making for patients admitted with COVID-19 disease

European Clinical Respiratory Journal, 2021
INTRODUCTION: COVID-19 is associated with a risk of severe pneumonia and acute respiratory distress syndrome (ARDS), requiring treatment at an intensive care unit (ICU).
Casper Falster, Niels Jacobsen, Lone Wulff Madsen, Line Dahlerup Rasmussen, Jesper Rømhild Davidsen, Fredrikke Christie Knudtzen, Stig Lønberg Nielsen, Isik Somuncu Johansen, Christian B. Laursen   +8 more
doaj   +1 more source

Cyclic Strain and Macrophage‐Mediated Transport Govern Micron‐Sized PM2.5 Translocation across the Air–Blood Barrier

Advanced Science, EarlyView.
Using a dynamic, tri‐culture air‐blood barrier model, this study reveals that macrophage‐mediated transport governs micron‐sized particle translocation under cyclic strain. The process is highly size‐dependent that 2 µm particles are transported by macrophages, 0.2 µm particles diffuse passively, and 5 µm particles are effectively blocked.
Yongjian Li, Jinlong Xu, Zujie Gao, Haosheng Chen   +3 more
wiley   +1 more source

Effect of Caring of Critically Sick Patients with COVID-19 Pneumonia at Undesignated ICU Wards on Secondary Infections

Dubai Medical Journal, 2022
Introduction: COVID-19 has caused high rates of mortality. During pandemic peak, a significant number of patients were admitted to undesignated ICU areas before transferring to designated ICU, owing to unavailability of ICU beds.
Rashid Nadeem, Moatz Galal Mohamed Ali Elzeiny, Ahmed Nazir Elsousi, Ashraf Elhoufi, Reham Helmy Amin Saad, Kishore Kumar, Sahish Kamat, Islam Bon, Akhter Mehmood, Irshad Basheer   +9 more
doaj   +1 more source

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury. [PDF]

, 2018
BackgroundComplications after injury, such as acute respiratory distress syndrome (ARDS), are common after traumatic brain injury (TBI) and associated with poor clinical outcomes.
Calfee, Carolyn S, Cohen, Mitchell J, Conroy, Amanda S, Gibb, Stuart L, Hendrickson, Carolyn M, Keating, Sheila M, Miyazawa, Byron Y, Pati, Shibani, Ross, Erin   +8 more
core  

Surface Reconstruction‐Free Stability Achieving Highly Anticorrosive Seawater Splitting

Advanced Science, EarlyView.
The complex metal oxides of AgCe‐FeMnOH can achieve an excellent oxygen evolution (OER) activity while maintaining its stability under alkaline seawater electrolysis. The surface reconstruction‐free behaviors lead to the durable seawater corrosion resistance without compromising the catalytic activities.
Yanita Devi, Ruspika Sundaresan, Tilahun Awoke Zegeye, Mariel G. Tecson, Guan‐Hong Guo, Wei‐Chun Lin, Yu‐Cheng Shao, Ching‐Wei Tung, Chun‐Hu Chen   +8 more
wiley   +1 more source