Results 91 to 100 of about 2,111,559 (284)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Oyster Bed Mapping in the Great Bay Estuary, 2012-2013 [PDF]

, 2013
Six major oyster beds (reefs) in New Hampshire are mapped periodically to assess wild oyster populations in the Great Bay Estuary. Data on the spatial extent of the beds are combined with density and other measures to estimate the abundances of live ...
Grizzle, Raymond E., Ward, Krystin M.
core   +2 more sources

Wireless Coverage Area Computation and Optimization

CoRR, 2015
Ph.D Thesis, Department of Computer Science and Engineering, IIT ...
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Nominal Evaluation of Automatic Multi-Sections Control Potential in Comparison to a Simpler One- or Two-Sections Alternative with Predictive Spray Switching

Agriculture
Automatic Section Control (ASC) promises to minimize spray overlap areas. The idea is to (i) switch off spray nozzles on areas that have already been sprayed, and (ii) to dynamically adjust nozzle flow rates along the boom bar that holds the spray ...
Mogens Plessen
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Research on Anti-Submarine Warfare Method of Unmanned Aerial Vehicle Cluster Based on Area Coverage and Distributed Optimization Control

Drones
Maritime security is vital to national security. The application of unmanned aerial vehicle (UAV) clusters in marine anti-submarine warfare (ASW) presents a new and significant challenge worthy of in-depth study.
Yongzhao Yan, Yi Liu, Ying Bi, Qian Wang, Huazhen Cao, Ziping Yu, Kangkang Li, Bo Wang, Xiaoping Ma   +8 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Grenzen eines Qualitätswettbewerbs der stationären Versorgung in Deutschland: eine Analyse aus den Daten des Bundes-Klinik-Atlas

Monitor Versorgungsforschung
Den Krankenhäusern in Deutschland wird gerne eine Über- und Fehlversorgung durch unnötige Leistungen und überflüssige Standorte unterstellt. Treiber dieser Annahme sind Themen wie Ambulantisierung und Zentralisierung.
Prof. Dr. med. Jürgen Stausberg, Thomas Jungen, Prof. Dr. med. Michael Karaus, Dr. med. Guido Lerzynski MSc MBA   +3 more
doaj   +1 more source

A Test Platform for Planned Field Operations Using LEGO Mindstorms NXT

Robotics, 2013
Testing agricultural operations and management practices associated with different machinery, systems and planning approaches can be both costly and time-consuming.
Gareth Edwards, Martin P. Christiansen, Dionysis D. Bochtis, Claus G. Sørensen   +3 more
doaj   +1 more source