Results 71 to 80 of about 4,372,005 (356)

Prequential AUC: properties of the area under the ROC curve for data streams with concept drift

open access: yesKnowledge and Information Systems, 2017
Modern data-driven systems often require classifiers capable of dealing with streaming imbalanced data and concept changes. The assessment of learning algorithms in such scenarios is still a challenge, as existing online evaluation measures focus on ...
D. Brzezinski, J. Stefanowski
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Vancomycin Area under the Curve and Acute Kidney Injury: A Meta-analysis.

open access: yesClinical Infectious Diseases, 2019
Objective To analyze the relationship between vancomycin AUC and acute kidney injury (AKI) reported across recent studies. Methods A systematic review of Pubmed, Medline, Scopus and compiled references was conducted. We included randomized, cohorts and
D. Aljefri   +5 more
semanticscholar   +1 more source

Spreading of Fluids on Solids Under Pressure: Effect of Slip [PDF]

open access: yes, 2010
Spreading of different types of fluid on substrates under an impressed force is an interesting problem. Here we study spreading of four fluids, having different hydrophilicity and viscosity on two substrates - glass and perspex, under an external force ...
Dutta, Tapati   +2 more
core  

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

Crop traits relevant for selecting potato genotypes adapted to low nitrogen availability [PDF]

open access: yes, 2012
Canopy cover development was measured for 6 to 18 different potato varieties, under 3 different nitrogen regimes. This canopy cover development can be expressed in several paramaters.
Lammerts van Bueren, E.T.   +2 more
core  

Development and validation of a prediction model on spontaneous preterm birth in twin pregnancy: a retrospective cohort study

open access: yesReproductive Health, 2023
Background This study was conducted to develop and validate an individualized prediction model for spontaneous preterm birth (sPTB) in twin pregnancies.
Xiaofeng Yang   +8 more
doaj   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

open access: yesFEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli   +10 more
wiley   +1 more source

Exploring Features for Predicting Policy Citations

open access: yes, 2017
In this study we performed an initial investigation and evaluation of altmetrics and their relationship with public policy citation of research papers. We examined methods for using altmetrics and other data to predict whether a research paper is cited ...
Alhoori, Hamed   +5 more
core   +1 more source

Optimal exposure targets for vancomycin in the treatment of neonatal coagulase-negative Staphylococcus infection: A retrospective study based on electronic medical records

open access: yesPediatrics and Neonatology, 2022
Background: The currently advocated ratio of area under the curve (AUC) over 24 h to minimum inhibitory concentration (AUC/MIC) > 400 and AUC  280 was a predictor of efficacy (OR: 13.960, 95% CI: 1.891–103.078, P  600 mg h/L was associated with AKI (OR ...
Quanyao Chen   +7 more
doaj  

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