Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Measuring the Discriminative Power of Rating Systems [PDF]
Assessing the discriminative power of rating systems is an important question to banks and to regulators. In this article we analyze the Cumulative Accuracy Profile (CAP) and the Receiver Operating Characteristic (ROC) which are both commonly used in ...
Engelmann, Bernd +2 more
core
Is the Area Under Curve Appropriate for Evaluating the Fit of Psychometric Models? [PDF]
Educ Psychol Meas, 2023 Han Y, Zhang J, Jiang Z, Shi D.
europepmc +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Diagnostic accuracy of heart rate variability as a screening tool for mild neurocognitive disorder
Frontiers in Aging NeuroscienceBackgroundMild neurocognitive disorder (mNCD) is recognized as an early stage of dementia and is gaining attention as a significant healthcare problem due to current demographic changes and increasing numbers of patients.
Julia Czopek-Rowinska +5 more
doaj +1 more source
Mean Arterial Pressure, Uterine Artery Doppler and Serum Placental Growth Factor Measured in First Trimester for Prediction of Preeclampsia: A Prospective Observational Study [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Preeclampsia affects 2 to 5% of pregnant women and is a leading cause of maternal and perinatal morbidity and mortality. Aim: To predict the development of preeclampsia during the first trimester by using mean arterial pressure, uterine ...
K Geetha +3 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Pharmacokinetics of cyclosporin: a microemulsion in children with idiopathic nephrotic syndrome
Clinics, 2012 OBJECTIVE: We present a prospective study of a microemulsion of cyclosporin to treat idiopathic nephrotic syndrome in ten children with normal renal function who presented cyclosporin trough levels between 50 and 150 ng/ml and achieved complete remission
Luciana dos Santos Henriques +2 more
doaj +1 more source
Area-Under-Curve-Guided Versus Trough-Guided Monitoring of Vancomycin and Its Impact on Nephrotoxicity: A Systematic Review and Meta-Analysis. [PDF]
Ther Drug Monit, 2023 Lim AS +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source