Results 81 to 90 of about 4,372,005 (356)

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Margin-based Ranking and an Equivalence between AdaBoost and RankBoost [PDF]

, 2009
We study boosting algorithms for learning to rank. We give a general margin-based bound for ranking based on covering numbers for the hypothesis space. Our bound suggests that algorithms that maximize the ranking margin will generalize well.
Rudin, Cynthia, Schapire, Robert E.
core   +2 more sources

Correlation of ureteric jet angle (UJA) with vesicoureteral reflux grade and its assessment as a noninvasive diagnostic parameter to detect vesicoureteral reflux

The Egyptian Journal of Radiology and Nuclear Medicine, 2023
Background Vesicoureteral reflux (VUR) is an essential urogenital entity affecting infants and younger children. Many patients present late with recurrent urinary tract infections (UTIs), which lead to chronic pyelonephritis, renal scarring, and end ...
Poornima Maravi, Lovely Kaushal, Bhagyashree Rathore, Anshuli Trivedi   +3 more
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Paraoxonase Activities in Metabolic Syndrome in Children and Adolescents

Caspian Journal of Internal Medicine, 2018
Background: Metabolic syndrome (MetS) is a collection of various interrelated risk factors that appear to have an impact as development of atherosclerotic cardiovascular disease (CVDs).
Arati Adhe-Rojekar, Mukund Ramchandra Mogarekar, Mohit Vijay Rojekar   +2 more
doaj  

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Comparative assessment of three common algorithms for estimating the variance of the area under the nonparametric receiver operating characteristic curve [PDF]

The area under the receiver operating characteristic (ROC) curve is often used to summarize and compare the discriminatory accuracy of a diagnostic test or modality,and to evaluate the predictive power of statistical models for binary outcomes ...
Mario A. Cleves
core   +1 more source

Receiver operating characteristic curve

Current Medicine Research and Practice, 2012
A receiver operating characteristic (ROC) curve is a plot of tradeoff between sensitivity and specificity. It is a plot that evaluates a diagnostic test for a continuous variable between diseased and non-diseased subjects.
Anita Singh, Vivek Choudhury, Satish Saluja   +2 more
doaj  

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source