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Cellular endosomal potassium ion flux regulates arenavirus uncoating during virus entry. [PDF]
Shaw AB +10 more
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Virome diversity in small mammals from south China: Insights into virus evolution, transmission, and ecology. [PDF]
Shi Y +19 more
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Arenavirus Gene Structure and Organization
1987For rhabdoviruses, paramyxoviruses, orthomyxoviruses, and some members of the Bunyaviridae, all the proteins are translated from the viral-complementary RNA sequence. This is in contrast to the genetic strategy of picornaviruses, caliciviruses, coronaviruses, togaviruses, flaviviruses, and retroviruses, whose proteins are all translated from the viral ...
D H, Bishop, D D, Auperin
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Structural components of the arenavirus Pichinde
Journal of Virology, 1977Purified Pichinde virions grown in monolayers of BHK-21 cells were found to contain three major species of virion proteins as described previously (Ramos et al., J. Virol. 10:661-667, 1972). Two of the proteins were glycosylated (G1, molecular weight = 64,000; G2, molecular weight = 38,000) and were present in similar proportions on the outer surface ...
A C, Vezza +3 more
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Structural insight into arenavirus replication machinery
Nature, 2020Arenaviruses can cause severe haemorrhagic fever and neurological diseases in humans and other animals, exemplified by Lassa mammarenavirus, Machupo mammarenavirus and lymphocytic choriomeningitis virus, posing great threats to public health1-4. These viruses encode a large multi-domain RNA-dependent RNA polymerase for transcription and replication of ...
Ruchao Peng +11 more
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Arenavirus extinction through lethal mutagenesis
Virus Research, 2005Viral hemorrhagic fevers represent serious human public health problems causing devastating and often lethal disease. Several hemorrhagic fevers are caused by arenaviruses including Lassa fever virus (LFV) and the South American viral hemorrhagic fevers (SAHF).
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Development of Recombinant Arenavirus-Based Vaccines
2017The development of arenavirus reverse genetics has provided investigators with a novel and powerful approach for the investigation of the arenavirus molecular and cell biology. The use of cell-based minigenome systems has allowed examining the cis- and trans-acting factors involved in arenavirus replication and transcription, and the identification of ...
Luis, Martínez-Sobrido +1 more
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Mapping Arenavirus Genes Causing Virulence
1987The reassortment of genetic information from RNA viruses with segmented genomes, i. e., Arenaviridae, Bunyaviridae, Orthomyxoviridae, and Reoviridae families, can occur within cells infected by two different viral strains from the same family (COmpans etal. 1981; FIelds and GReene 1982; WEbster etal. 1982; Palese 1984).
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Pathology and Pathogenesis of Arenavirus Infections
1987In systemic virus infections, such as the arenavirus hemorrhagic fevers, pathologic and histopathologic examinations often contribute to the initial understanding of the nature of the disease, but definition of pathogenic mechanisms requires the addition of complementary techniques and experimental approaches – usually in animal models. The commonality
D H, Walker, F A, Murphy
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Treatment of Arenavirus Infections
Current Treatment Options in Infectious Diseases, 2015Arenaviruses are a cause of several potentially fatal viral hemorrhagic fevers. While lymphocytic choriomeningitis virus is found worldwide, the remaining arenaviruses have limited geographic ranges. These zoonoses are generally transmitted to humans after exposure to aerosolized excreta or to blood or other body fluids of the rodent.
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