Results 81 to 90 of about 2,647 (168)

Review of Mammarenavirus Biology and Replication

Frontiers in Microbiology, 2018
The family Arenaviridae is divided into three genera: Mammarenavirus, Reptarenavirus, and Hartmanivirus. The Mammarenaviruses contain viruses responsible for causing human hemorrhagic fever diseases including New World viruses Junin, Machupo, Guanarito ...
Steven J. Hallam, Takaaki Koma, Junki Maruyama, Slobodan Paessler   +3 more
doaj   +1 more source

Involvement of Pro-Inflammatory Macrophages in Liver Pathology of Pirital Virus-Infected Syrian Hamsters

Viruses, 2018
New World arenaviruses cause fatal hemorrhagic disease in South America. Pirital virus (PIRV), a mammarenavirus hosted by Alston’s cotton rat (Sigmodon alstoni), causes a disease in Syrian golden hamsters (Mesocricetus auratus) (biosafety level-3 ...
Corey L. Campbell, Aaron T. Phillips, Amber Rico, Amanda McGuire, Tawfik A. Aboellail, Sandra Quackenbush, Ken E. Olson, Tony Schountz   +7 more
doaj   +1 more source

The Lassa Virus Stable Signal Peptide Undergoes a Conformational Change to Aid Viral Fusion

Chemistry – A European Journal, Volume 31, Issue 18, March 25, 2025.
The unique stable signal peptide (SSP) of the Lassa virus glycoprotein complex undergoes a conformational change during pH‐dependent viral fusion. This revels a potential mechanism by which the enigmatic SSP influences the fusion process through interactions it makes with the fusion protein, glycoprotein 2 (GP2).
Shane D. Collins, Liqun Jiang, Yanxin Liu, Jinwoo Lee   +3 more
wiley   +1 more source

Two Birds With One Stone: RNA Virus Strategies to Manipulate G3BP1 and Other Stress Granule Components

WIREs RNA, Volume 16, Issue 2, March/April 2025.
Stress granules emerging during viral infection can play both pro‐ and antiviral roles. RNA viruses use various strategies to antagonize their formation, including the degradation, inhibition, or sequestration of G3BP1, a key stress granule protein. However, biochemical and structural insights into these mechanisms have been reported for only a handful
Moh Egy Rahman Firdaus, Eliana Dukhno, Rupali Kapoor, Piotr Gerlach   +3 more
wiley   +1 more source

Junin Virus Triggers Macrophage Activation and Modulates Polarization According to Viral Strain Pathogenicity

Frontiers in Immunology, 2019
The New World arenavirus Junin (JUNV) is the etiological agent of Argentine hemorrhagic fever (AHF). Previous studies of human macrophage infection by the Old-World arenaviruses Mopeia and Lassa showed that while the non-pathogenic Mopeia virus ...
María F. Ferrer, Pablo Thomas, Aída O. López Ortiz, Aída O. López Ortiz, Andrea E. Errasti, Nancy Charo, Victor Romanowski, Victor Romanowski, Juan Gorgojo, María E. Rodriguez, Eugenio A. Carrera Silva, Ricardo M. Gómez, Ricardo M. Gómez   +12 more
doaj   +1 more source

New World Arenaviruses: Host Reservoirs, Viral Diversity and Pathogenic Mechanisms

Microbiology Research Journal International
Introduction: Arenaviridae can cause diseases such as lymphocytic choriomeningitis, Lassa fever, Argentine hemorrhagic fever, Bolivian hemorrhagic fever, and Brazilian hemorrhagic fevers. Their main etiological agents are Sabiá virus, Flexal virus, Amapari virus, Juquitiba virus, lymphocytic choriomeningitis virus, Lassa virus, Junin virus, and Machupo
Leite Júnior, Diniz Pereira, Vivi Oliveira, Viviane Karolina, Castoldo Passos, João Pedro, Thies, Sirlei Franck, Menegatti, Jaqueline Aparecida, de Paula, Cristiane Coimbra, da Silva Maia, Margareth Léa   +6 more
openaire   +2 more sources

Bacterial-based systems for expression and purification of recombinant Lassa virus proteins of immunological relevance

Virology Journal, 2008
Background There is a significant requirement for the development and acquisition of reagents that will facilitate effective diagnosis, treatment, and prevention of Lassa fever.
Cashman Kathleen A, Ferro Philip J, Sampey Darryl B, Goba Augustine, Fair Joseph N, Matschiner Alex, Branco Luis M, Schoepp Randal J, Tesh Robert B, Bausch Daniel G, Garry Robert F, Guttieri Mary C   +11 more
doaj   +1 more source

Broad‐Spectrum Antiviral Activity of the Orally Bioavailable Antiviral ATV014 Against Multiple Coronaviruses

MedComm, Volume 6, Issue 5, May 2025.
Sidi Yang, Kun Li, Qifan Zhou, Xumu Zhang, Deyin Guo   +4 more
wiley   +1 more source

CD164 is an endolysomal host factor for entry of Clade A New World Arenaviruses

Abstract Arenaviruses are divided into Old World (OW) and New World (NW) groups. OW arenaviruses enter cells through a pH-dependent receptor switch from a plasma-membrane factor to an endolysosomal receptor for subsequent membrane fusion, whereas clade B NW arenaviruses use transferrin receptor 1 without a secondary receptor.
Cassandra E. Thompson, Tomasz Kaszuba, Rita M. Meganck, Marjorie Cornejo Pontelli, Paul W. Rothlauf, Mason A. Roth, Zhuoming Liu, Hongming Ma, John Doench, Michael S. Diamond, Daved H. Fremont, Sean P.J. Whelan   +11 more
openaire   +1 more source

Old and New World arenaviruses share a highly conserved epitope in the fusion domain of the glycoprotein 2, which is recognized by Lassa virus-specific human CD4+ T-cell clones

Virology, 2004
Data from human studies and animal experiments indicate a dominant role of T-cells over antibodies in controlling acute Lassa virus infection and providing immunity to reinfection. Knowledge of the epitopes recognized by T-cells may therefore be crucial to the development of a recombinant Lassa virus vaccine.
Meulen, Jan ter, Badusche, Marlis, Satoguina, Judith, Strecker, Thomas, Lenz, Oliver, Loeliger, Cornelius, Sakho, Mohamed, Koulemou, Kekoura, Koivogui, Lamine, Hoerauf, Achim   +9 more
openaire   +2 more sources