Results 101 to 110 of about 4,023 (209)

Development and characterization of a reverse genetics system for the lineage II Chicava strain of Machupo virus in a guinea pig model. [PDF]

PLoS Negl Trop Dis
BackgroundMachupo virus (MACV) is a New World mammarenavirus (hereafter referred to as "arenavirus") and the etiologic agent of Bolivian hemorrhagic fever (BHF).
Mantlo E, Maruyama J, Manning JT, Reyna RA, Huang C, Paessler S.   +5 more
europepmc   +2 more sources

Two Birds With One Stone: RNA Virus Strategies to Manipulate G3BP1 and Other Stress Granule Components

WIREs RNA, Volume 16, Issue 2, March/April 2025.
Stress granules emerging during viral infection can play both pro‐ and antiviral roles. RNA viruses use various strategies to antagonize their formation, including the degradation, inhibition, or sequestration of G3BP1, a key stress granule protein. However, biochemical and structural insights into these mechanisms have been reported for only a handful
Moh Egy Rahman Firdaus, Eliana Dukhno, Rupali Kapoor, Piotr Gerlach   +3 more
wiley   +1 more source

Using modelling to disentangle the relative contributions of zoonotic and anthroponotic transmission: the case of lassa fever. [PDF]

, 2015
BACKGROUND: Zoonotic infections, which transmit from animals to humans, form the majority of new human pathogens. Following zoonotic transmission, the pathogen may already have, or may acquire, the ability to transmit from human to human. With infections
Cunningham, Andrew A, Fichet-Calvet, Elisabeth, Garry, Robert F, Grant, Donald S, Khan, Sheik Humarr, Leach, Melissa, Lo Iacono, Giovanni, Moses, Lina M, Schieffelin, John S, Shaffer, Jeffrey G, Webb, Colleen T, Wood, James LN   +11 more
core   +4 more sources

Involvement of Pro-Inflammatory Macrophages in Liver Pathology of Pirital Virus-Infected Syrian Hamsters

Viruses, 2018
New World arenaviruses cause fatal hemorrhagic disease in South America. Pirital virus (PIRV), a mammarenavirus hosted by Alston’s cotton rat (Sigmodon alstoni), causes a disease in Syrian golden hamsters (Mesocricetus auratus) (biosafety level-3 ...
Corey L. Campbell, Aaron T. Phillips, Amber Rico, Amanda McGuire, Tawfik A. Aboellail, Sandra Quackenbush, Ken E. Olson, Tony Schountz   +7 more
doaj   +1 more source

Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions

Advanced Science, Volume 12, Issue 3, January 20, 2025.
Live attenuated vaccines represent a delicate equilibrium between virulence and immunogenicity during adaptation. The process of animal adaptation involves artificial selection; therefore, adapted viruses exhibit decreased pathogenicity to their original hosts and increased pathogenicity to their adapted hosts.
Yan‐Dong Tang, Yuming Li, Xue‐Hui Cai, Xin Yin   +3 more
wiley   +1 more source

Macaque models of human infectious disease. [PDF]

, 2008
Macaques have served as models for more than 70 human infectious diseases of diverse etiologies, including a multitude of agents-bacteria, viruses, fungi, parasites, prions.
Abe, Adams, Ahmed, Ajariyakhajorn, Albrecht, Allen, Apetrei, Apetrei, Arroyo, Bai, Bannantine, Barker, Barnett, Barouch, Baskerville, Baskin, Baze, Bennett, Blanchard, Blaney, Bons, Boonjakuakul, Breitschwerdt, Brooks, Brown, Bruce, Campos, Capone, Capone, Carbone, Carlson, Carlson, CARVALHO, Chan, Chattopadhyay, Chen, Chen, Chenine, Choi, Chomel, Choo, Chopra, Christe, Coalson, Coban, Cohen, Cohen, Contreras, Courgnaud, Custer, Cypess, Daddario-DiCaprio, Daddario-Dicaprio, Dalgard, Daniel, de Swart, Dezzutti, Di Giulio, Dittmer, Doi, Donnelly, Dubois, Dubois, Dutta, Earl, Edghill-Smith, Edghill-Smith, Ekanayake, Engel, Escalante, Espana, Farber, Feichtinger, Fisher-Hoch, Fisher-Hoch, Fitzgeorge, Fogg, Foley, Foucault, Fritz, Frolova, Gajdusek, Gallinella, Gao, Gardner, Gardner, Gardner, Gaynor, Geisbert, Geisbert, Geisbert, Geisbert, Gheit, Gibbs, Giddens, Goldstein, Gonder, Good, Gormus, Gormus, Goverdhan, Graczyk, Graff, Gray, Green, Guirakhoo, Haagmans, Haase, Habis, Hambleton, Hansen, Hawley, Heise, Heraud, Herzog, Hessell, Hicks, Higashi, Hirano, Hirsch, Hooper, Hotez, Hubbert, Hull, Hunsmann, Hutin, Ilyinskii, Inoue, Ivanoff, Jahrling, Ji, Johnson, Johnson, Jones-Engel, Jones-Engel, Kao, Kawai, Kawai, Kennedy, Kenyon, Kestler, Kinsey, Kishimoto, Klingstrom, Klumpp, Kobasa, Kobune, Kodama, Kornegay, Kuiken, Kuiken, Kunz, Kutok, Kwang, Lackner, Lake-Bakaar, Lasm  zas, Le Bras, Leong, Leroy, Letvin, Letvin, Letvin, Levine, Li, Li, Lichtenwalner, Lindsley, Line, Ling, Linial, Lockridge, Lodmell, Lowenstine, Lukashevich, Lukashevich, Lusso, Maddison, Mankowski, Mansfield, Mansfield, Marra, Marthas, Marthas, Marx, Mason, Masters, Matz-Rensing, Maul, McArthur-Vaughan, McMichael, McNeely, McShane, Meisenhelder, Mense, Miller, Miyoshi, Moghaddam, Monath, Mon  , Mooser, Morris, Morton, Mulder, Murphey-Corb, Murphy, Murphy, Myint, Nagle, NI, North, Novembre, O'Rourke, O'Sullivan, O'Sullivan, Olson, Ostrow, Ostrow, Oswald, Pachner, Pachner, Pachner, Pahar, Palmer, Palmer, Patton, Patton, Paul, Peiris, Percy, Perelygina, Permar, Persson, Peters, Peters, Petschow, Philipp, Philipp, Phipps, Pialoux, Pletnev, Polack, Pung, Puri, Raengsakulrach, Raether, Ratterree, Reed, Reimann, Reindel, Renne, Rhesus Macaque Genome Sequencing and Analysis Cons, Rimmelzwaan, Rimmelzwaan, Rivailler, Rockx, Rodas, Rue, Ruff, Russell, Saadat, Sale, Samuel, Sato, Schou, Schou, Schricker, Schultz, Sequar, Sestak, Shah, Shen, Shevtsova, Shuto, Simoes, Smit-McBride, Smith, Smith, Soike, Solnick, Solnick, Spencer, Stittelaar, Stittelaar, Stittelaar, Stokes, Subekti, Suss, Tanaka, Tanghe, Taylor, Taylor, Tribe, Tulis, Turell, Uberla, van den Hoogen, van Gorder, Van Heuverswyn, Van Rompay, Van Voorhis, Vasconcelos, Vasconcelos, Veazey, Voevodin, Vogel, Walsh, WALSH, Weinmann, Weiss, Wells, Wengelnik, Wenner, Westerman, White, Whitney, Williamson, Williamson, Willy, Wobus, Wolf, Wolfe, Wood, Wright, Wyatt, Xu, Yalcin, Zaucha, Zhou, Zuckerman, Zumpe   +330 more
core   +1 more source

Macrophage Transcriptomic Alterations Driven by Alphavirus‐Based Cancer Immunotherapy Vectors

Journal of Immunology Research, Volume 2025, Issue 1, 2025.
Cancer cells promote the polarisation of tumour‐associated macrophages (TAMs) into pro‐tumorigenic M2‐like phenotype, contributing to cancer progression. Reprogramming TAMs by viral immunotherapy vectors represents a promising strategy for cancer therapy.
Ksenija Korotkaja, Darija Lapina, Zhanna Rudevica, Anna Zajakina, Esha Saini   +4 more
wiley   +1 more source

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice. [PDF]

, 2015
A major advantage of microfluidic devices is the ability to manipulate small sample volumes, thus reducing reagent waste and preserving precious sample. However, to achieve robust sample manipulation it is necessary to address device integration with the
Benett, William J, Bora, Mihail, Burklund, Alison, Fong, Erika J, Hamilton, Julie, Huang, Chao, Metz, Thomas R, Shusteff, Maxim   +7 more
core   +1 more source

Junin Virus Triggers Macrophage Activation and Modulates Polarization According to Viral Strain Pathogenicity

Frontiers in Immunology, 2019
The New World arenavirus Junin (JUNV) is the etiological agent of Argentine hemorrhagic fever (AHF). Previous studies of human macrophage infection by the Old-World arenaviruses Mopeia and Lassa showed that while the non-pathogenic Mopeia virus ...
María F. Ferrer, Pablo Thomas, Aída O. López Ortiz, Aída O. López Ortiz, Andrea E. Errasti, Nancy Charo, Victor Romanowski, Victor Romanowski, Juan Gorgojo, María E. Rodriguez, Eugenio A. Carrera Silva, Ricardo M. Gómez, Ricardo M. Gómez   +12 more
doaj   +1 more source

La schizophrénie touche aussi les enfants et les adolescents : une des modalités de leur prise en charge est assurée par le CTJA [Centre thérapeutique de jour pour adolescents] [PDF]

, 2004
1% des schizophrénies se déclenchent avant l'âge de 10 ans. 20%, une sur cinq, commencent avant l'âge de 18 ans. Et dans 40% des cas de schizophrénie avérée, les premiers signes étaient apparus avant 18 ans.
Dunand, Fabien, Holzer, Laurent
core