Results 141 to 150 of about 78,666 (255)

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Nitric Oxide Synthase Activity Correlates with OGG1 in Ozone-Induced Lung Injury Animal Models

Frontiers in Physiology, 2017
Background: NO is an important cellular signaling molecule which is derived from L-arginine by nitric oxide synthase (NOS) and the effects of NOS signaling in lung injury is conflicting.
Jianhua Li, Suqin Zhang, Yuqin Li, Yufeng Liu, Hongxiang Guo, Xiaoli Xu   +5 more
doaj   +1 more source

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. [PDF]

, 2014
It is well known that the ω-3 fatty acids (ω-3-FAs; also known as n-3 fatty acids) can exert potent anti-inflammatory effects. Commonly consumed as fish products, dietary supplements and pharmaceuticals, ω-3-FAs have a number of health benefits ascribed ...
Akiyama, Taro E, Armando, Aaron M, Bogner-Strauss, Juliane G, Chi, Tyler J, Chung, Heekyung, Cox, Jason M, Di Salvo, Jerry, Evans, Ronald M, Hah, Nasun, Lackey, Denise, Lagakos, William S, McNelis, Joanne, Oh, Da Young, Olefsky, Jerrold M, Pessentheiner, Ariane R, Powels, Mary Ann, Quehenberger, Oswald, Sasik, Roman, Sinz, Christopher, Walenta, Evelyn, Watkins, Steven M   +20 more
core   +1 more source

Synthesis, In Silico, and In Vitro Evaluation of Anti-Leishmanial Activity of Oxadiazoles and Indolizine Containing Compounds Flagged against Anti-Targets

Molecules, 2019
Due to the lack of approved vaccines against human leishmaniasis and the limitations of the current chemotherapy inducing side effects and drug resistance, development of new, effective chemotherapeutic agents is essential.
Strahinja Stevanovic, Milan Sencanski, Mathieu Danel, Christophe Menendez, Roumaissa Belguedj, Abdelmalek Bouraiou, Katarina Nikolic, Sandrine Cojean, Philippe M. Loiseau, Sanja Glisic, Michel Baltas, Alfonso T. García-Sosa   +11 more
doaj   +1 more source

Critical role for arginase 2 in obesity-associated pancreatic cancer

Nature Communications, 2017
Obesity is an established risk factor for pancreatic ductal adenocarcinoma (PDA). Despite recent identification of metabolic alterations in this lethal malignancy, the metabolic dependencies of obesity-associated PDA remain unknown.
Tamara Zaytouni, Pei-Yun Tsai, Daniel S. Hitchcock, Cory D. DuBois, Elizaveta Freinkman, Lin Lin, V. Morales-Oyarvide, P. Lenehan, B. Wolpin, M. Mino‐Kenudson, Eduardo M. Torres, N. Stylopoulos, C. Clish, Nada Y. Kalaany   +13 more
semanticscholar   +1 more source

Trypanosomatid Infections: How Do Parasites and Their Excreted–Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages?

Frontiers in Immunology, 2018
Mononuclear phagocytes (monocytes, dendritic cells, and macrophages) are among the first host cells to face intra- and extracellular protozoan parasites such as trypanosomatids, and significant expansion of macrophages has been observed in infected hosts.
Philippe Holzmuller, Philippe Holzmuller, Anne Geiger, Romaric Nzoumbou-Boko, Romaric Nzoumbou-Boko, Romaric Nzoumbou-Boko, Joana Pissarra, Sarra Hamrouni, Valérie Rodrigues, Valérie Rodrigues, Frédéric-Antoine Dauchy, Frédéric-Antoine Dauchy, Frédéric-Antoine Dauchy, Jean-Loup Lemesre, Philippe Vincendeau, Philippe Vincendeau, Philippe Vincendeau, Rachel Bras-Gonçalves   +17 more
doaj   +1 more source

Pulmonary hypertension in adolescents with sickle cell disease [PDF]

, 2016
Sickle cell disease consists of a group of disorders that have a similar mutation in at least one of the beta-globin chains of hemoglobin. This results in a change of the hemoglobin to sickle shaped cells when in the deoxygenated state.
Akinyemi, Katherine
core   +1 more source

Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma

Journal of Hematology & Oncology, 2018
BackgroundMetastatic melanoma is an aggressive skin cancer with a poor prognosis. Current treatment strategies for high-stage melanoma are based around the use of immunotherapy with immune checkpoint inhibitors such as anti-PDL1 or anti-CTLA4 antibodies ...
Carmela De Santo, P. Cheng, A. Beggs, S. Egan, A. Bessudo, F. Mussai   +5 more
semanticscholar   +1 more source

Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac aging

eLife
Aging is a predominant risk factor for heart disease. Aging heart reveals low-grade chronic inflammation, cell apoptosis, cardiac fibrosis, and increased vulnerability to ischemic injury.
Duilio M Potenza, Xin Cheng, Guillaume Ajalbert, Andrea Brenna, Marie-Noelle Giraud, Aurelien Frobert, Stephane Cook, Kirsten D Mertz, Zhihong Yang, Xiu-Fen Ming   +9 more
doaj   +1 more source

Macrophage polarization impacts tunneling nanotube formation and intercellular organelle trafficking. [PDF]

, 2019
Tunneling nanotubes (TNTs) are cellular extensions enabling cytosol-to-cytosol intercellular interaction between numerous cell types including macrophages.
Cherqui, Stephanie, Goodman, Spencer, Khan, Meisha, Naphade, Swati, Sharma, Jay   +4 more
core   +1 more source