Results 51 to 60 of about 65,972 (187)

Severe COVID-19 Is Characterized by an Impaired Type I Interferon Response and Elevated Levels of Arginase Producing Granulocytic Myeloid Derived Suppressor Cells

Frontiers in Immunology, 2021
COVID-19 ranges from asymptomatic in 35% of cases to severe in 20% of patients. Differences in the type and degree of inflammation appear to determine the severity of the disease.
Matthew J. Dean, Juan B. Ochoa, Maria Dulfary Sanchez-Pino, Maria Dulfary Sanchez-Pino, Jovanny Zabaleta, Jovanny Zabaleta, Jone Garai, Luis Del Valle, Luis Del Valle, Dorota Wyczechowska, Lyndsey Buckner Baiamonte, Phaethon Philbrook, Phaethon Philbrook, Rinku Majumder, Richard S. Vander Heide, Logan Dunkenberger, Ramesh Puttalingaiah Thylur, Bobby Nossaman, W. Mark Roberts, Andrew G. Chapple, Andrew G. Chapple, Jiande Wu, Chindo Hicks, Jack Collins, Brian Luke, Randall Johnson, Hari K. Koul, Hari K. Koul, Chris A. Rees, Claudia R. Morris, Julia Garcia-Diaz, Augusto C. Ochoa, Augusto C. Ochoa   +32 more
doaj   +1 more source

SPARC is a new myeloid-derived suppressor cell marker licensing suppressive activities [PDF]

, 2019
Myeloid-derived suppressor cells (MDSC) are well-known key negative regulators of the immune response during tumor growth, however scattered is the knowledge of their capacity to influence and adapt to the different tumor microenvironments and of the ...
Botti L., Cappetti B., Chiodoni C., Colombo M. P., Consonni F. M., Gulino A., Nicola M. D., Portararo P., Randon G., Sangaletti S., Sica A., Talarico G., Tripodo C.   +12 more
core   +3 more sources

Crystallization of Arginase [PDF]

Nature, 1946
ATTEMPTS to obtain arginase in a pure state were only partly successful and resulted in an approximately twenty-fold purification of the enzyme from liver extracts1,2,3.
openaire   +2 more sources

Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR–/–and LDLR+/+mice [PDF]

, 2017
© 2017 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd. INTRODUCTION: Fatty liver disease is prevalent in populations with high caloric intake.
Asai, Baldock, Bieghs, Bora, Cani, Chan, Chawla, Del Ben, DeLuca, Dongiovanni, Drewnowski, George, Giugliano, Glaros, Hummasti, Iwaki, Jorde, Jump, Kalra, Karbowska, Kennedy, Kheder, Kitson, Kleiner, Kraakman, Lira, Livak, Lytle, Machado, Madar, Marcotorchino, Merat, Minto, Oh, Okamoto, Parekh, Pham, Roth, Saraswathi, Schwen, Sergeev, Shu, Subramanian, Teramoto, Tintut, Vanlint, Wortsman, Wouters, Yin, Zhang, Zhang   +50 more
core   +1 more source

Possible Involvement of Altered Arginase Activity, Arginase Type I and Type II Expressions, and Nitric Oxide Production in Occurrence of Intimal Hyperplasia in Premenopausal Human Uterine Arteries

Journal of Pharmacological Sciences, 2008
In the present experiments, we tried to elucidate whether changes in arginase activity and protein expression of arginase I and II are involved in the occurrence of intimal hyperplasia in premenopausal human uterine arteries.
Galina Vasileva Marinova, Renzo Ygor Loyaga-Rendon, Satoshi Obayashi, Tomoko Ishibashi, Toshiro Kubota, Masatoshi Imamura, Hiroshi Azuma   +6 more
doaj   +1 more source

Treating Macrophages with Anti-inflammatory Nanoparticles as a Strategy to Improve Muscle Repair [PDF]

, 2019
The macrophage is an immune cell that is involved in host defense. More recent research, however, has revealed that they also play a central role in mediating the skeletal muscle regenerative process.
Yan, Derek
core   +1 more source

Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents

Frontiers in Chemistry, 2021
Arginase catalyzes the hydrolysis of l-arginine into l-ornithine and urea, acting as a key enzyme in the biosynthesis of polyamines. Leishmania growth and survival is dependent on polyamine biosynthesis; therefore, inhibition of Leishmania arginase may ...
Andreza R. Garcia, Danielle M. P. Oliveira, Jessica B. Jesus, Jessica B. Jesus, Alessandra M. T. Souza, Ana Carolina R. Sodero, Alane B. Vermelho, Ivana C. R. Leal, Rodrigo Octavio M. A. Souza, Leandro S. M. Miranda, Anderson S. Pinheiro, Igor A. Rodrigues, Igor A. Rodrigues   +12 more
doaj   +1 more source

Arginase and pulmonary diseases [PDF]

Naunyn-Schmiedeberg's Archives of Pharmacology, 2008
Recent studies have indicated that arginase, which converts L-arginine into L-ornithine and urea, may play an important role in the pathogenesis of various pulmonary disorders. In asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis, increased arginase activity in the airways may contribute to obstruction and hyperresponsiveness of ...
Maarsingh, Harm, Pera, Tonio, Meurs, Herman   +2 more
openaire   +3 more sources

The kinetic properties of arginase in sperm cells of inferile men

Regulatory Mechanisms in Biosystems, 2018
Nowadays the role of NO in the development of male infertility is actively studied. Arginase (EC 3.5.3.1) is a manganese metalloenzyme which converts L-arginine to L-ornithine and urea and reciprocally regulates NO production.
R. V. Fafula, U. P. Iefremova, O. K. Onufrovych, H. V. Maksymyuk, D. Z. Vorobets, Z. D. Vorobets   +5 more
doaj   +1 more source

Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

Journal for ImmunoTherapy of Cancer, 2019
Background Tumor orchestrated metabolic changes in the microenvironment limit generation of anti-tumor immune responses. Availability of arginine, a semi-essential amino acid, is critical for lymphocyte proliferation and function.
Juan J. Miret, Paul Kirschmeier, Shohei Koyama, Mingrui Zhu, Yvonne Y. Li, Yujiro Naito, Min Wu, Venkat S. Malladi, Wei Huang, William Walker, Sangeetha Palakurthi, Glenn Dranoff, Peter S. Hammerman, Chad V. Pecot, Kwok-Kin Wong, Esra A. Akbay   +15 more
doaj   +1 more source