Results 91 to 100 of about 473,606 (232)

Citrulline supplementation improves organ perfusion and arginine availability under conditions with enhanced arginase activity [PDF]

, 2015
Enhanced arginase-induced arginine consumption is believed to play a key role in the pathogenesis of sickle cell disease-induced end organ failure. Enhancement of arginine availability with l-arginine supplementation exhibited less consistent results ...
Benjamin Vandendriessche, Bessems, Babs AFM, Poeze, Martijn, Brouckaert, Peter, Karolina Wijnands, Ruben Visschers, Babs Bessems, Wijnands, Karolina AP, Bouvy, Nicole D, Nicole Bouvy, van Barneveld, Kevin WY, van Eijk, Hans MH, Visschers, Ruben G. J., Visschers, Ruben GJ, Meesters, Dennis M, Peter Brouckaert, Bessems, Babs A. F. M., Vandendriessche, Benjamin, van Barneveld, Kevin W. Y., Meesters, Dennis M., Nadine Hoven, Martijn Poeze, Lamers, Wouter H, Wouter Lamers, Anje Cauwels, Kevin Van Barneveld, Cauwels, Anje, Christian Von Wintersdorff, Hans Van Eijk, von Wintersdorff, Christian JH, van Eijk, Hans M. H., Briede, Jacob J., von Wintersdorff, Christian J. H., Jacob Briedé, Lamers, Wouter H., Bouvy, Nicole D., Dennis Meesters, Briedé, Jacob J, van den Hoven, Nadine, Wijnands, Nina   +39 more
core   +1 more source

DataSheet2_Hepatic Ischemia-Reperfusion Impairs Blood-Brain Barrier Partly Due to Release of Arginase From Injured Liver.ZIP

, 2021
Aim: Hepatic ischemia-reperfusion (HIR) induces remote organs injury, including the brain. The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus, we aimed to investigate whether HIR impaired BBB and attempted to elucidate its ...
Yun Sheng (4267843), Weimin Kong (2558737), Liang Zhu (172992), Li Liu (75607), Xiaodong Liu (403701), Hanyu Yang (8374881), Peihua Liu (11556460), Han Zhou (109068), Feng Xu (89016), Lu Yang (30847), Xiaonan Liu (142071), Ping Li (31981)   +11 more
core   +1 more source

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Vasomotor Regulation of Coronary Microcirculation by Oxidative Stress: Role of Arginase

Frontiers in Immunology, 2013
Overproduction of reactive oxygen species, i.e., oxidative stress, is associated with the activation of redox signaling pathways linking to inflammatory insults and cardiovascular diseases by impairing endothelial function and consequently blood flow ...
Lih eKuo, Lih eKuo, Lih eKuo, Travis eHein, Travis eHein   +4 more
doaj   +1 more source

Human Salivary Arginase and Its Deficiency in Argininaemia1) [PDF]

, 1984
Summary: Arginase from normal human mixed saliva was characterized. The enzyme was completely activated after a preincubation of 20min at 55 °C and a Mn2+ final concentration of 5 mmol/1.
Konarska, L., Tomaszewski, L., L. Tomaszewski, Terheggen, H. G., J. P. Colombo, H. G. Terheggen, Colombo, J. P., L. Konarska   +7 more
core   +1 more source

Table5_Hepatic Ischemia-Reperfusion Impairs Blood-Brain Barrier Partly Due to Release of Arginase From Injured Liver.XLSX

, 2021
Aim: Hepatic ischemia-reperfusion (HIR) induces remote organs injury, including the brain. The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus, we aimed to investigate whether HIR impaired BBB and attempted to elucidate its ...
Yun Sheng (4267843), Weimin Kong (2558737), Liang Zhu (172992), Li Liu (75607), Xiaodong Liu (403701), Hanyu Yang (8374881), Peihua Liu (11556460), Han Zhou (109068), Feng Xu (89016), Lu Yang (30847), Xiaonan Liu (142071), Ping Li (31981)   +11 more
core   +1 more source

Chrysanthemum Morifolium–Derived Nanovesicles Reduce Lactate‐Associated Histone Lactylation and Modulate Microglia‐Mediated Neuroinflammation in Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
When used to treat sepsis‐associated encephalopathy, Chrysanthemum morifolium–derived nanovesicles can inhibit the H3K18la/NF‐κB axis to regulate microglia‐mediated neuroinflammation. ABSTRACT Sepsis‐associated encephalopathy (SAE)—a complication of the central nervous system in patients with sepsis—markedly diminishes cognitive functions and is linked
Kaiqiang Li, Xuling Luo, Xiaoting Zhang, Chengwen He, Wei Xu, Aibo Xu, Shushan Hua, Liping Wang, Liang Ma, Ke Hao, Youmin Ying, Zhen Wang   +11 more
wiley   +1 more source

Image1_Hepatic Ischemia-Reperfusion Impairs Blood-Brain Barrier Partly Due to Release of Arginase From Injured Liver.TIF

, 2021
Aim: Hepatic ischemia-reperfusion (HIR) induces remote organs injury, including the brain. The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus, we aimed to investigate whether HIR impaired BBB and attempted to elucidate its ...
Yun Sheng (4267843), Weimin Kong (2558737), Liang Zhu (172992), Li Liu (75607), Xiaodong Liu (403701), Hanyu Yang (8374881), Peihua Liu (11556460), Han Zhou (109068), Feng Xu (89016), Lu Yang (30847), Xiaonan Liu (142071), Ping Li (31981)   +11 more
core   +1 more source

Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming

Advanced Science, EarlyView.
Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva, Virginia Marcia Concato‐Lopes, Fatima Bedier, Lauren Newman, Diana Kitka, Jamelle Brown, Blandine Victor, Minhyung Kim, Tatyana Vagner, Catherine Grasso, Dmitriy Sheyn, Sungyong You, Michael R. Freeman, Fayyaz S. Sutterwala, Helen S. Goodridge, Caroline Jefferies, Paola de Candia, Jlenia Guarnerio, Dolores Di Vizio   +18 more
wiley   +1 more source

DataSheet8_Hepatic Ischemia-Reperfusion Impairs Blood-Brain Barrier Partly Due to Release of Arginase From Injured Liver.ZIP

, 2021
Aim: Hepatic ischemia-reperfusion (HIR) induces remote organs injury, including the brain. The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus, we aimed to investigate whether HIR impaired BBB and attempted to elucidate its ...
Yun Sheng (4267843), Weimin Kong (2558737), Liang Zhu (172992), Li Liu (75607), Xiaodong Liu (403701), Hanyu Yang (8374881), Peihua Liu (11556460), Han Zhou (109068), Feng Xu (89016), Lu Yang (30847), Xiaonan Liu (142071), Ping Li (31981)   +11 more
core   +1 more source