Results 151 to 160 of about 473,606 (232)

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang, Siwen Wu, Yusi Wang, Die Hu, Li Yang   +4 more
wiley   +1 more source

Analysis of treatment methods for arginase deficiency

Highlights in Science, Engineering and Technology
Arginase deficiency is a rare, critical and highly lethal inherited metabolic disorder which may lead to impaired motor skills and neurodevelopmental deficits. Three mainstay treatment options have been arisen: drugs, liver transplantation surgery, and dietary control.
openaire   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Arginase deficiency in Mexico: Insights from the experience of a metabolic reference center. [PDF]

Mol Genet Metab Rep
Vela-Amieva M, Fernández-Lainez C, Guillén-López S, López-Mejía L, Alcántara-Ortigoza MA, González Del Angel A, Fernández-Hernández L, Reyna-Fabián ME, Estandía-Ortega B, Ibarra-González I, Ryu SW, Lee H, Rare Diseases Mexican Effort Group (RaDiMEG).   +12 more
europepmc   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

4‐1BBL Suppresses Anti‐Inflammatory Responses by Regulating Metabolic Reprogramming of Macrophages

Immunology, Volume 179, Issue 3, Page 434-443, November 2026.
4‐1BB ligand (4‐1BBL) is known to promote sustained pro‐inflammatory responses in macrophages. This study demonstrates that 4‐1BBL acts as a negative regulator of anti‐inflammatory macrophage responses. Genetic deletion or pharmacological inhibition of 4‐1BBL significantly enhanced the phosphorylation of IL‐4R‐proximal JAK1 and STAT6, elevating the ...
Young Jun Kang
wiley   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Dietary Arginine Sets the Pace of MHC Class I Translation: A Nutrient Lever on Tumour Immunogenicity

MedComm, Volume 7, Issue 11, November 2026.
Mohammad Asim
wiley   +1 more source

Alox15 restrains glycolysis to support M2 macrophage effector function during helminth immunity. [PDF]

J Exp Med
Ovezgeldiyev D, Trefzer V, Doolan R, Moyat M, Coakley G, Wickramasinghe LC, Daunt C, Volpe B, Henkel F, Serra A, Hartmann M, Rezaei S, Ubags N, Butler A, Chatzis R, Marsland BJ, Smith AAT, Deveson Lucas D, McGowan ENS, Binger KJ, McConville MJ, Esser-von Bieren J, Harris NL, Bouchery T.   +23 more
europepmc   +1 more source

The Janus face of L-arginine supplementation in cardiovascular health and aging exploration of underlying mechanisms. [PDF]

Front Aging
Yang Z, Ming XF, Potenza DM.
europepmc   +1 more source