Results 31 to 40 of about 473,606 (232)

Acute liver failure-induced arginine deficiency impairs blood-brain barrier via inhibiting mTORC1-S6K1/4EBP1 pathway and inducing autophagy. [PDF]

Cell Death Dis
Blood-brain barrier (BBB) impairment plays a crucial role in the development of hepatic encephalopathy. Our previous work demonstrated that hepatic ischemia-reperfusion-induced acute liver failure (ALF) impairs the BBB by releasing arginase, but the ...
Yang H, Kong W, Jiang L, Zhu L, Wang X, Yang L, Qian L, Xu Z, Zhang C, Liu X, Liu L.   +10 more
europepmc   +2 more sources

Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia. [PDF]

, 2013
The underlying mechanisms resulting in the profound immune suppression characteristic of human visceral leishmaniasis (VL) are not fully understood. Here, we tested the hypothesis that arginase, an enzyme associated with immunosuppression, is higher in ...
Corset, C, Cloke Tom, Closs Ellen, Cloke, T, Yifru Sisay, Abebe Tamrat, Corset, M, Modolell, M, Takele, Yegnasew, Corware, Karina, Cloke, Tom, Sisay Yifru, Hailu, Workagegnehu, Munder, M, Tacchini-Cottier, F, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Weldegebreal, T, Weldegebreal Teklu, Teklu Weldegebreal, Closs, E, Sisay, Y, Hailu, W, Mueller, I, Pascale Kropf, Camille Corset, Müller Ingrid, Sisay, Yifru, Takele Yegnasew, Closs, Ellen, Karina Corware, Weldegebreal, Teklu, Modolell, Manuel, Corware, K, Asrat Hailu, Corware Karina, Abebe, T, Corset Margaux, Munder, Markus, Manuel Modolell, Hailu Workagegnehu, Hailu, A, Margaux Corset, Modolell Manuel, Workagegnehu Hailu, Kropf Pascale, Abebe, Tamrat, Tacchini-Cottier, Fabienne, Fabienne Tacchini-Cottier, Yegnasew Takele, Kropf, Pascale, Corset Camille, Munder Markus, Tom Cloke, Corset, Margaux, Ellen Closs, Tacchini-Cottier Fabienne, Hailu Asrat, Corset, Camille, Hailu, Asrat, Takele, Y, Tamrat Abebe, Closs, E., Abebe, T., Corset, C., Takele, Y., Sisay, Y., Hailu, A., Müller, I., Weldegebreal, T., Corset, M., Corware, K., Cloke, T., Modolell, M., Munder, M., Kropf, P., Tacchini-Cottier, F., Hailu, W.   +79 more
core   +1 more source

Epithelial arginase-1 is a key mediator of age-associated delayed healing in vaginal injury

Frontiers in Endocrinology, 2022
Pelvic organ prolapse is a disorder that substantially affects the quality of life of millions of women worldwide. The greatest risk factors for prolapse are increased parity and older age, with the largest group requiring surgical intervention being ...
Holly N. Wilkinson, Benjamin Reubinoff, Benjamin Reubinoff, David Shveiky, David Shveiky, Matthew J. Hardman, Ofra Ben Menachem-Zidon   +6 more
doaj   +1 more source

Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion. [PDF]

, 2013
Tumor-growth is often associated with the expansion of myeloid derived suppressor cells that lead to local or systemic arginine depletion via the enzyme arginase.
Hundemer, Michael, Voss, R-H, Sergej Medenhoff, Voss Ralf-Holger, Goldschmidt, Hartmut, Knies, D, Anthony D Ho, Voss, Ralf-Holger, Knies Diana, Engelhardt, Melanie, Wabnitz, Guido, Knies, Diana, Michael Hundemer, Diana Knies, Yvonne Samstag, Munder, M, Feldmeyer, N, Samstag, Y, Theobald, Matthias, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Conradi Roland, Nadja Feldmeyer, Luckner-Minden, Claudia, Conradi, R, Roland Conradi, Mueller, I, Pascale Kropf, Matthias Theobald, Wabnitz, G, Conradi, Roland, Ho, AD, Müller Ingrid, Goldschmidt Hartmut, Hundemer Michael, Hundemer, M, Medenhoff, Sergej, Claudia Luckner-Minden, Luckner-Minden Claudia, Wabnitz Guido, Engelhardt, M, Samstag, Yvonne, Munder, Markus, Guido Wabnitz, Feldmeyer, Nadja, Theobald, M, Feldmeyer Nadja, Engelhardt Melanie, Medenhoff Sergej, Kropf Pascale, Hartmut Goldschmidt, Theobald Matthias, Ho, Anthony D, Medenhoff, S, Ralf-Holger Voss, Goldschmidt, H, Kropf, Pascale, Munder Markus, Ho Anthony D., Samstag Yvonne, Melanie Engelhardt, Luckner-Minden, C   +63 more
core   +2 more sources

Review of Multi-Modal Imaging in Urea Cycle Disorders: The Old, the New, the Borrowed, and the Blue

Frontiers in Neurology, 2021
The urea cycle disorders (UCD) are rare genetic disorder due to a deficiency of one of six enzymes or two transport proteins that act to remove waste nitrogen in form of ammonia from the body.
Kuntal Sen, Afrouz A. Anderson, Matthew T. Whitehead, Andrea L. Gropman   +3 more
doaj   +1 more source

Arginase from kiwifruit: properties and seasonal variation [PDF]

, 1997
The in vitro activity of arginase (EC 3.5.3.1) was investigated in youngest-mature leaves and roots (1-3 mm diameter) of kiwifruit vines (Actinidia deliciosa var. deliciosa) during an annual growth cycle, and enzyme from root material partially purified.
Petach, Helen H., C. A. Hale, C. J. Clark, H. H. Petach, Clark, Christopher J., Daniel, Roy M., R. M. Daniel, Hale, C.A.   +7 more
core   +1 more source

Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia. [PDF]

, 2012
BACKGROUND: Cutaneous leishmaniasis is a vector-borne disease that is in Ethiopia mainly caused by the parasite Leishmania aethiopica. This neglected tropical disease is common in rural areas and causes serious morbidity.
Cloke, T, Abebe Tamrat, Mekonen Woinshet, Modolell, M, Thomas Cloke, Woldeyes Mihretu, Seich Al Basatena, Nafisa-Katrin, Abebe, T., Corware, Karina, Bilcha, K, Seich al Basatena, N., Munder, M, Lionel Fry, Tacchini-Cottier, F, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Bilcha, K., Fry Lionel, Seich Al Basatena, N.K., Cloke Thomas, Hailu, A., Cloke, Thomas, Mueller, I, Mihretu Woldeyes, Pascale Kropf, Müller Ingrid, Mekonen, Woinshet, Karina Corware, Modolell, Manuel, al Basatena, N-KS, Müller, I., Woldeyes, M, Woinshet Mekonen, Corware, K, Asrat Hailu, Kassahun Bilcha, Corware Karina, Abebe, T, Woldeyes, Mihretu, Munder, Markus, Manuel Modolell, Mekonen, W., Hailu, A, Modolell Manuel, Fry, Lionel, Kropf Pascale, Abebe, Tamrat, Fry, L., Fry, L, Corware, K., Cloke, T., Modolell, M., Munder, M., Tacchini-Cottier, Fabienne, Fabienne Tacchini-Cottier, Kropf, P., Kropf, Pascale, Bilcha, Kassahun, Tacchini-Cottier, F., Woldeyes, M., Munder Markus, Nafisa-Katrin Seich Al Basatena, Mekonen, W, Tacchini-Cottier Fabienne, Hailu Asrat, Hailu, Asrat, Tamrat Abebe, Bilcha Kassahun, Seich al Basatena Nafisa-Katrin   +70 more
core   +1 more source

Novel ARG1 variants identified in a patient with arginase 1 deficiency

Human Genome Variation, 2021
We report a case of a 13-year-old boy with arginase 1 deficiency carrying a new variant in ARG1. Sanger sequencing identified the compound heterozygous variants: NM_000045.4: c.365G>A (p.Trp122*)/c.820G>A (p.Asp274Asn).
Katsuyuki Yokoi, Yoko Nakajima, Toshihiro Yasui, Makoto Yoshino, Tetsushi Yoshikawa, Hiroki Kurahashi, Tetsuya Ito   +6 more
doaj   +1 more source

Age-related alteration of arginase activity impacts on severity of leishmaniasis. [PDF]

, 2008
BACKGROUND: The leishmaniases are a group of vector-borne parasitic diseases that represent a major international public health problem; they belong to the most neglected tropical diseases and have one of the highest rates of morbidity and mortality. The
Asrat Hailu, Choi, B., Abebe, T, Munder, Markus, Choi, B-S, Abebe Tamrat, Modolell, M, Choi Beak-San, Manuel Modolell, Hailu, A, Abebe, T., Fuentes, J., Modolell Manuel, Kropf Pascale, Abebe, Tamrat, Munder, M, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Modolell, M., Munder, M., Kropf, P., Kropf, Pascale, Beak-San Choi, Hailu, A., Fuentes, Jose M, Munder Markus, Fuentes Jose M., Pascale Kropf, Muller, I, Fuentes, JM, Jose M. Fuentes, Müller Ingrid, Jose M Fuentes, Hailu Asrat, Choi, Beak-San, Hailu, Asrat, Modolell, Manuel, Müller, I., Tamrat Abebe   +40 more
core   +2 more sources

Mouse Model for Human Arginase Deficiency [PDF]

Molecular and Cellular Biology, 2002
Deficiency of liver arginase (AI) causes hyperargininemia (OMIM 207800), a disorder characterized by progressive mental impairment, growth retardation, and spasticity and punctuated by sometimes fatal episodes of hyperammonemia. We constructed a knockout mouse strain carrying a nonfunctional AI gene by homologous recombination.
Ramaswamy K, Iyer, Paul K, Yoo, Rita M, Kern, Nora, Rozengurt, Rosemarie, Tsoa, William E, O'Brien, Hong, Yu, Wayne W, Grody, Stephen D, Cederbaum   +8 more
openaire   +2 more sources