Results 41 to 50 of about 473,606 (232)

Anesthetic management of a pediatric patient with arginase-1 deficiency undergoing strabismus operation: a case report

JA Clinical Reports, 2019
Background Urea cycle disorders are rare; arginase-1 deficiency is one of those extremely rare autosomal recessive metabolic disorders. Arginase-1 is one among the enzymes involved in the production of urea from ammonia in the liver, and its deficiency ...
Hideya Kato, Ken Kawaguchi, Teiji Sawa
doaj   +1 more source

Arginases and arginine deficiency syndromes [PDF]

Current Opinion in Clinical Nutrition and Metabolic Care, 2012
Many physiologic and pathophysiologic processes are modulated by arginine availability, which can be regulated by arginase. An understanding of the conditions that result in elevated arginase activity as well as the consequences of arginine deficiency is essential for design of effective nutritional support for disease.
openaire   +2 more sources

IL-10 and TGF-β Induced Arginase Expression Contributes to Deficient Nitric Oxide Response in Human Visceral Leishmaniasis

Frontiers in Cellular and Infection Microbiology, 2021
Nitric oxide (NO) is an anti-microbial effector of the innate immune system which plays major role in non-specific killing of various pathogens including protozoan parasites.
Manu Kupani, Smriti Sharma, Rajeev Kumar Pandey, Rajiv Kumar, Shyam Sundar, Sanjana Mehrotra   +5 more
doaj   +1 more source

Arginine depletion as a mechanism for the immune privilege of corneal allografts. [PDF]

, 2011
The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine transplant model.
Larkin, Daniel FP, George, Andrew J.T., Fu, Hongmei, Coe, D, Hongmei Fu, Chai, J-G, Zaher, S, David Coe, George, Andrew JT, Fu, H, Khan, A, Larkin, Daniel F.P., Jian-Guo Chai, Ingrid Müller, Kropf, P, Müller, Ingrid, Kropf, Pascale, Larkin, DFP, George, AJT, Adnan Khan, Khan, Adnan, Zaher, Sarah, Daniel F. P. Larkin, Mueller, I, Pascale Kropf, Coe, David, Sarah Zaher, Andrew J. T. George, Chai, Jian-Guo   +28 more
core   +1 more source

Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice

BMC Immunology, 2009
Background Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not been fully elucidated in mice.
Rothenberg Marc E, Wills-Karp Marsha, O'Brien William E, Cederbaum Stephen D, Hajek Amanda R, Collier Ann R, Niese Kathryn A, Zimmermann Nives   +7 more
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

sj-pdf-1-pat-10.1177_2632010X221093274 – Supplemental material for Hyperargininemia Due to Arginase 1 Deficiency: Variability in Clinical and Biochemical Presentations in Malaysian children

, 2022
Supplemental material, sj-pdf-1-pat-10.1177_2632010X221093274 for Hyperargininemia Due to Arginase 1 Deficiency: Variability in Clinical and Biochemical Presentations in Malaysian children by Anasufiza Habib and Norashareena Mohamed Shakrin in Clinical ...
Anasufiza Habib (12427778), Norashareena Mohamed Shakrin (12427781)   +1 more
core   +1 more source

Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma

Respiratory Research, 2006
Background Using guinea pig tracheal preparations, we have recently shown that endogenous arginase activity attenuates inhibitory nonadrenergic noncholinergic (iNANC) nerve-mediated airway smooth muscle relaxation by reducing nitric oxide (NO) production
Zaagsma Johan, Bos I Sophie T, Leusink John, Maarsingh Harm, Meurs Herman   +4 more
doaj   +1 more source

Immunologic Studies of Arginase in Tissues of Normal Human Adult and Arginase-Deficient Patients [PDF]

Pediatric Research, 1983
Rabbit antibody to human liver arginase was used to examine the immunologic characteristics of arginase in red blood cells (RBC), liver, kidney, brain, and gastrointestinal tract from normal adults and from patients with hyperargininemia. Greater than 90% of the arginase in RBC and liver was precipitated by this antibody whereas only 50% of the ...
E B, Spector, S C, Rice, S D, Cederbaum
openaire   +2 more sources

TIPE2 negatively regulates inflammation by switching arginine metabolism from nitric oxide synthase to arginase. [PDF]

PLoS ONE, 2014
TIPE2, the tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TNFAIP8L2), plays an essential role in maintaining immune homeostasis. It is highly expressed in macrophages and negatively regulates inflammation through inhibiting Toll-like ...
Yunwei Lou, Guizhong Zhang, Minghong Geng, Wenqian Zhang, Jian Cui, Suxia Liu   +5 more
doaj   +1 more source