Results 1 to 10 of about 844,163 (322)

Inhibition of Tumor Microenvironment-Driven JAK-STAT Signaling Enhances Response to Arginine Deprivation Therapy in Triple-Negative Breast Cancer. [PDF]

Cells
Argininosuccinate synthetase 1 (ASS1) expression and arginine availability are key metabolic determinants that influence tumor fitness and regulate immune interactions within the tumor microenvironment (TME).
Tishler H, Ziman S, Cheng K, Wang K, Sanghvi N, Adler L, Stelzer G, Maniriho H, Dassa B, Bab-Dinitz E, Levi M, Galai S, Goldman O, Ariav Y, Darzi N, Ezagouri S, Nimni N, Rosenfeld N, Rotkopf R, Brandis A, Mehlman T, Oren R, Zerbib M, Kuznetsov Y, Donzelli S, Blandino G, Seger R, Ruppin E, Erez A.   +28 more
europepmc   +2 more sources

Estimation of genetic parameters for egg production traits in Japanese quail that selected for immune responses and fed different level of dietary L-arginine [PDF]

مجلة جامعة كركوك للعلوم الزراعية, 2023
This study was conducted in the fields of the Department of Animal Production - College of Agriculture at Kirkuk University for the period from 6/14/2021 to 7/30/2022.
Ahmed Shaker, Ayhan Mohammed, Waleed Razuki   +2 more
doaj   +1 more source

Protocol to assess the tolerogenic properties of adoptively transferred dendritic cells during murine experimental autoimmune encephalomyelitis

STAR Protocols, 2022
Summary: By their capacity to induce peripheral T cell tolerance, dendritic cells (DCs) present a promising target cell and therapeutic strategy for treatment of several autoimmune diseases including multiple sclerosis (MS).
Andrea Vogel, Martina Kerndl, Gernot Schabbauer, Omar Sharif   +3 more
doaj   +1 more source

Arginine reprograms metabolism in liver cancer via RBM39

Cell, 2023
Summary Metabolic reprogramming is a hallmark of cancer. However, mechanisms underlying metabolic reprogramming and how altered metabolism in turn enhances tumorigenicity are poorly understood.
Dirk Mossmann, Christoph Müller, Sujin Park, Brendan Ryback, M. Colombi, N. Ritter, Diana Weissenberger, E. Dazert, M. Coto-Llerena, Sandro Nuciforo, Lauriane Blukacz, Caner Ercan, V. Jiménez, Salvatore Piscuoglio, Fatima Bosch, Luigi Terracciano, U. Sauer, Markus H. Heim, Michael N. Hall   +18 more
semanticscholar   +1 more source

Arginine-dependent immune responses

Cellular and Molecular Life Sciences, 2021
A growing body of evidence indicates that, over the course of evolution of the immune system, arginine has been selected as a node for the regulation of immune responses.
Adrià-Arnau Martí i Líndez, W. Reith
semanticscholar   +1 more source

Protein arginine methyltransferases: promising targets for cancer therapy

Experimental and Molecular Medicine, 2021
Protein methylation, a post-translational modification (PTM), is observed in a wide variety of cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic research, the importance of protein methylation has been ...
J. Hwang, Y‐E Cho, G. Bae, Su-Nam Kim, Yong Kee Kim   +4 more
semanticscholar   +1 more source

Arginine Signaling and Cancer Metabolism

Cancers, 2021
Simple Summary In this review, we describe arginine’s role as a signaling metabolite, epigenetic regulator and mitochondrial modulator in cancer cells, and summarize recent progress in the application of arginine deprivation as a cancer therapy. Abstract
Chia-Lin Chen, S. Hsu, David Ann, Y. Yen, H. Kung   +4 more
semanticscholar   +1 more source

Arginine Supply Impacts the Expression of Candidate microRNA Controlling Milk Casein Yield in Bovine Mammary Tissue

Animals, 2020
Arginine, a semi-essential functional amino acid, has been found to promote the synthesis of casein in mammary epithelial cells to some extent. Data from mouse indicated that microRNA (miRNA) are important in regulating the development of mammary gland ...
Xin Zhang, Yifan Wang, Mengzhi Wang, Gang Zhou, Lianmin Chen, Luoyang Ding, Dengpan Bu, Juan Loor   +7 more
doaj   +1 more source

Hydrophobicity of arginine leads to reentrant liquid-liquid phase separation behaviors of arginine-rich proteins

Nature Communications, 2022
Intrinsically disordered proteins rich in cationic amino acid groups can undergo Liquid-Liquid Phase Separation (LLPS) in the presence of charge-balancing anionic counterparts.
Yu Hong, Saeed Najafi, Thomas Casey, J. Shea, Song-I Han, D. Hwang   +5 more
semanticscholar   +1 more source

GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment.

Cell Metabolism, 2022
Hepatocellular carcinoma (HCC) is a typically fatal malignancy exhibiting genetic heterogeneity and limited therapy responses. We demonstrate here that HCCs consistently repress urea cycle gene expression and thereby become auxotrophic for exogenous ...
R. Missiaen, Nicole M. Anderson, Laura C. Kim, Bailey Nance, Michelle Burrows, Nicolas Skuli, Madeleine Carens, Romain Riscal, A. Steensels, Fuming Li, M. Simon   +10 more
semanticscholar   +1 more source