Hyaluronan-Arginine Enhanced Interaction Emerges from Distinctive Molecular Signature with Improved Electrostatics and Side-Chain Specificity [PDF]
arXiv, 2023 Hyaluronan, a sugar polymer found outside the plasma membrane, is a critical component of the extracellular matrix (ECM) scaffold. Hyaluronan's length and moderate negative charge aid in ECM entanglement and solubility. This allows it to effectively foster gel-like conditions, which are critical for supporting and protecting cells in various tissues ...
arxiv
To Be or Not To Be a Molecular Ion: The Role of the Solvent in Photoionization of Arginine. [PDF]
, 2019 Application of photoionization mass spectroscopy, a technique capable of assessing protonation states in complex molecules in the gas phase, is challenging for arginine due to its fragility. We report photoionization efficiencies in the valence region of
Ahmed, Musahid +7 more
core +2 more sources
A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa [PDF]
, 2018 Nutrients such as amino acids play key roles in shaping the metabolism of microorganisms in natural environments and in host–pathogen interactions.
Cutruzzolà, F. +8 more
core +1 more source
Arginine-enriched mixed-charge domains provide cohesion for nuclear speckle condensation
bioRxiv, 2019 Low-complexity protein domains promote the formation of various biomolecular condensates. However, in many cases, the precise sequence features governing condensate formation and identity remain unclear.
Jamie A. Greig +6 more
semanticscholar +1 more source
Journal of Dental Sciences, 2013 The prevalence of dentin hypersensitivity in Taiwan has been reported up to 38%. The aim of this study was to evaluate the clinical efficacy of desensitizing toothpaste containing 8.0% arginine and calcium carbonate in treating dentin hypersensitivity ...
Hui-Chieh Hsu +2 more
doaj +1 more source
Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii [PDF]
, 2019 Toxoplasma gondii is a prevalent protozoan parasite that can infect any nucleated cell but cannot replicate outside of its host cell. Toxoplasma is auxotrophic for several nutrients including arginine, tryptophan, and purines, which it must acquire from ...
Amin, Parth H. +3 more
core +1 more source
Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
Science, 2015 Sensing amino acids at the lysosome The mTORC1 protein kinase is a complex of proteins that functions to regulate growth and metabolism. Activity of mTORC1 is sensitive to the abundance of amino acids, but how the sensing of amino acids is coupled to the
Shuyu Wang +17 more
semanticscholar +1 more source
Entropic stabilization of proteins and its proteomic consequences [PDF]
, 2005 We report here a new entropic mechanism of protein thermostability due to residual dynamics of rotamer isomerization in native state. All-atom simulations show that Lysines have much greater number of accessible rotamers than Arginines in folded states of proteins.
arxiv +1 more source
Electron Attachment to DNA: The Protective Role of Amino Acids [PDF]
, 2022 We have studied the effect of amino acids on electron attachment properties of DNA nucleobases, taking cytosine as a model system. The equation of motion coupled cluster theory with an extended basis set has been used to simulate the electron-attached state of the DNA model system. Four selected amino acids, Arginine, Alanine, Lysine, and Glycine which
arxiv +1 more source
Claws, Disorder, and Conformational Dynamics of the C-terminal Region of Human Desmoplakin [PDF]
The Journal of Physical Chemistry B (2016), 2016 Multicellular organisms consist of cells that interact via elaborate adhesion complexes. Desmosomes are membrane-associated adhesion complexes that mechanically tether the cytoskeletal intermediate filaments (IFs) between two adjacent cells, creating a network of tough connections in tissues such as skin and heart.
arxiv +1 more source