Results 121 to 130 of about 283,349 (208)

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Adipsic Hypernatremia Complicated by Hyperosmolar Hyperglycemic State and Extensive Venous Thromboembolism After Traumatic Brain Injury: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACTAdipsic hypernatremia is a rare disorder characterized by impaired thirst perception despite severe hyperosmolality, most commonly resulting from hypothalamic dysfunction. Hyperosmolar hyperglycemic state (HHS) may further aggravate dehydration and electrolyte imbalance, increasing the risk of neurologic injury, acute kidney injury (AKI), and ...
Mahshad Ghoddusi, Khashayar Shahverdi, Negar Zareshahi, Zahra Shafizadeh, Mohammad Taghi Talebian, Amir Shokri, Fatemeh Afra   +6 more
wiley   +1 more source

Serpin A1 Cargo Within Tumour‐Derived Extracellular Vesicles Supports Pro‐Tumoural Bias of Neutrophils in Cancer

Journal of Extracellular Vesicles, Volume 15, Issue 11, November 2026.
ABSTRACT Tumour‐derived extracellular vesicles (EVs) or exosomes are critical mediators of the cancer‐immune system crosstalk, yet the mechanisms by which they reprogram neutrophil function in vivo remain insufficiently characterised. Here, we identify the serine protease inhibitor Serpin A1 as a predominant cargo component of small EVs (sEVs) released
Maksim Domnich, Ekaterina Pylaeva, Elena Siakaeva, Nastassia Kabankova, Agnieszka Bedzinska, Damian Sojka, Aneta Zebrowska, Marta Gawin, Maren Soldierer, Yaping Yu, Malwina Rist, Daniel Fochtman, Bernd Giebel, Iris Helfrich, Ilona Thiel, Basant Kumar Thakur, Cornelius H. L. Kürten, Helmut Hanenberg, Sonja Ludwig, Piotr Widlak, Stephan Lang, Monika Pietrowska, Jadwiga Jablonska   +22 more
wiley   +1 more source

Tailored Amino Acid Treatment for Pediatric Patients With Mitochondrial Aminoacyl‐tRNA Synthetase Deficiencies

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Aminoacyl‐tRNA synthetases (ARSs) facilitate the loading of transfer RNAs with their cognate amino acids in the cytosol (ARS1), mitochondria (ARS2), or both (dual ARS). ARS deficiencies are clinically heterogeneous and can cause severe, occasionally fatal disease.
I. J. J. Muffels, G. Kok, Z. Tang, L. S. Medeiros, F. O. Poswar, W. P. Vermeij, R. Rodenburg, K. Smit, S. K. Sukumaran, S. B. Wortmann, L. Averdunk, J. Munch, J. Pak‐lam Ho, A. M. K. Kwok, E. E. S. Nieuwenhuis, P. M. van Hasselt, I. V. D. Schwartz, C. M. A. Lubout, A. M. Bosch, K. Koop, E. M. M. Hoytema van Konijnenburg, S. A. Fuchs   +21 more
wiley   +1 more source

Revisiting Inherited Metabolic Diseases (IMDs) Through the Lens of Selective Autophagy

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Selective autophagy is increasingly recognized as a fundamental quality‐control mechanism that complements bulk autophagy by enabling the targeted degradation of specific intracellular cargos, including mitochondria, endoplasmic reticulum (ER), lipid droplets, glycogen, peroxisomes, ferritin, ribosomes, and protein aggregates.
Marianna Maddaluno, Laura Cinque, Viviana Cetrangolo, Chiara De Leonibus   +3 more
wiley   +1 more source

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang, Siwen Wu, Yusi Wang, Die Hu, Li Yang   +4 more
wiley   +1 more source

Leishmania parasite arginine deprivation response pathway influences the host macrophage lysosomal arginine sensing machinery

The outcome of infection is greatly influenced by extensive interaction between the metabolic networks of the host and the pathogen. The intracellular protozoan parasite Leishmania donovani causes competition between the host and the parasite for ...
Selvapandiyan, Angamuthu, Madan, Evanka, Zilberstein, Dan, Pawar, Harsh, Puri, Madhu, Ganguly, Nirmal Kumar, Muthuswami, Rohini, Madhubala, Rentala   +7 more
core   +3 more sources

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

Genetic Engineering Efforts to Generate Chlamydomonas Strains for Large‐Scale Biomolecule Production

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
This represents the main aspects relevant to potential industrialization of Chlamydomonas. ABSTRACT Chlamydomonas reinhardtii is an established model microalga. Its easy manipulation, metabolic flexibility and tractable genomes allowed researchers to investigate fundamental processes such as photosynthesis using genetic studies for decades ...
Sofia Inturri, Nicolas Rouhier, Claire Remacle   +2 more
wiley   +1 more source

A Conserved Isoleucine Gates the Diffusion of CO and O2 to the Active Site of NiFe CO‐Dehydrogenase

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
A combination of protein film electrochemistry and site‐directed mutagenesis shows that isoleucine 563 (numbering of Thermococcus sp. AM4) gates the arrival of both CO and O2 to the active site of the nickel‐iron CO dehydrogenases. Mutations at this position increase the resistance to O2 at the cost of a slower reaction with CO.
Laura Opdam, Marta Meneghello, Chloé Guendon, Jade Chargelègue, Andrea Fasano, Aurore Jacq‐Bailly, Christophe Léger, Vincent Fourmond   +7 more
wiley   +2 more sources