Results 111 to 120 of about 283,349 (208)

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Global research trends and emerging themes in amino acid deprivation based cancer therapy: a bibliometric and visualization study

Frontiers in Immunology
BackgroundAmino acid deprivation and restriction have emerged as metabolically informed anticancer strategies, encompassing dietary interventions, enzyme-mediated depletion, and pathway-targeted approaches.
Xiuli He, Tao Cai, Guoqin Zhang, Shulin Cheng, Wensheng Yue   +4 more
doaj   +1 more source

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

The FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

The Effect of PTPN22 Polymorphism on Juvenile Idiopathic Arthritis Subtypes and Disease Activity in a Finnish Study Population

International Journal of Immunogenetics, EarlyView.
ABSTRACT Genetic factors that modulate immune regulation are increasingly recognised as contributors to the heterogeneity and clinical course of autoimmune diseases. Polymorphisms of protein tyrosine phosphatase non‐receptor type 22 (PTPN22) are associated with several autoimmune diseases.
Sonja Kvist, Johanna Teräsjärvi, Heidi Rahikkala, Jussi Mertsola, Milja Möttönen, Qiushui He   +5 more
wiley   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

CD4+ T Cell‐Intrinsic Arg1 Regulates Th1 Dynamics in Influenza: Functional and Translational Implications for Infection and Cancer Inflammation

Allergy, EarlyView.
Anishaa Balaji, Sophia N. Karagiannis, Alexandra J. McCraw   +2 more
wiley   +1 more source

Perturbation of Spermine Homoeostasis Uncouples Hypersensitive Cell Death From Systemic Plant Immunity

Plant, Cell &Environment, EarlyView.
ABSTRACT Polyamines are key regulators of plant stress responses, yet their contribution to coordinating local immune responses with systemic immunity remains poorly understood. Here, we investigated how spermine (Spm) homeostasis influences local and systemic defence responses in Arabidopsis thaliana following inoculation with Pseudomonas syringae pv.
Jiaqi Zhao, Kostadin E. Atanasov, Olga Jauregui, Rubén Alcázar   +3 more
wiley   +1 more source

Exploring the difference in arginine biosynthesis activity and response to arginine deprivation in pancreatic and colorectal cancer cell lines

Tumoral loss of argininosuccinate synthetase (ASS1), the penultimate arginine synthesis enzyme converting citrulline and aspartate into argininosuccinate, is associated with vulnerability to arginine-depleting agents e.g. ADI-PEG20.
Turner, E
core   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, Volume 20, Issue 11, Page 2584-2610, November 2026.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo

, 2015
The strategy of enzymatic degradation of amino acids to deprive malignant cells of important nutrients is an established component of induction therapy of acute lymphoblastic leukemia.
Bonnet, Dominique, Anjos-Afonso, Fernando, Gribben, John G., Taussig, David C., Ariza-McNaughton, Linda, Cavenagh, Jamie, Grantham, Marianne, Clear, Andrew, Bomalaski, John S., Sohrabi, Fareeda, Hodby, Katharine A., Ghazaly, Essam, Liapis, Konstantinos, Miraki-Moud, Farideh, Szlosarek, Peter W.   +14 more
core   +1 more source