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Arginine Deprivation as a Targeted Therapy for Cancer [PDF]
Current Pharmaceutical Design, 2008 Certain cancers may be auxotrophic for a particular amino acid and amino acid deprivation is one method to treat these tumors. Arginine deprivation is a novel approach to target tumors which lack argininosuccinate synthetase (ASS) expression.
Lynn G Feun
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Arginine Metabolism and Deprivation in Cancer Therapy
Biomedicine and Pharmacotherapy, 2019 Certain cancer cells with nutrient auxotrophy and have a much higher nutrient demand compared with normal human cells. Arginine as a versatile amino acid, has multiple biological functions in metabolic and signaling pathways. Depletion of this amino acid by arginine depletor is generally well tolerated and has become a targeted therapy for arginine ...
Shi Xu, Changneng Ke
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The Arginine Metabolism and Its Deprivation in Cancer Therapy
Cancer LettersArginine deprivation has emerged as a promising therapeutic strategy in cancer treatment due to the auxotrophy of certain tumors. Many cancers, such as pancreatic, colorectal, and hepatocellular carcinoma, exhibit downregulated argininosuccinate synthetase, making them reliant on external arginine sources. This dependency allows targeted therapies that
Chi Man Tsang, Bonan Chen, Wei Kang
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Transport of L-Arginine in Arginine-Deprived Endothelial Cells
Biochemical and Biophysical Research Communications, 1995In vascular endothelium, L-arginine (ARG) plays a crucial role as a substrate for various metabolic pathways, one of which is the synthesis of bioregulatory nitric oxide. Transport of ARG across the cell membrane determines intracellular substrate availability.
H, Preik-Steinhoff +3 more
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Arginine depriving enzymes: applications as emerging therapeutics in cancer treatment
Cancer Chemotherapy and Pharmacology, 2021Cancer is the second leading cause of death globally. Chemotherapy and radiation therapy and other medications are employed to treat various types of cancer. However, each treatment has its own set of side effects, owing to its low specificity. As a result, there is an urgent need for newer therapeutics that do not disrupt healthy cells' normal ...
Neha Kumari, Saurabh Bansal
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Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer
International Journal of Cancer, 2010AbstractArginine, a semi‐essential amino acid in humans, is critical for the growth of human cancers, particularly those marked by de novo chemoresistance and a poor clinical outcome. In addition to protein synthesis, arginine is involved in diverse aspects of tumour metabolism, including the synthesis of nitric oxide, polyamines, nucleotides, proline ...
Delage, B +6 more
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Dietary Arginine Deprivation and Delayed Puberty in the Female Rat
The Journal of Nutrition, 1984Dietary arginine deprivation was found to delay puberty in the female rat. Physiological pinealectomy by exposing to constant light suggests this gland is not involved in this delay. Compensatory ovarian hypertrophy (COH) was used to test the hypothalamic sensitivity to negative steroid feedback.
M Y, Pau, J A, Milner
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Effect of arginine deprivation on macromolecular processes in Burkitt's lymphoblasts
Experimental Cell Research, 1970Abstract Cultured Burkitt's lymphoblasts responded in synchronized macromolecular syntheses to medium replenishment. Addition of arginine-deprived medium resulted in DNA synthesis, at a lower rate than the controls. The replication of DNA was not accompanied with RNA and protein synthesis. The effect of arginine deprivation markedly differed from the
A, Weinberg, Y, Becker
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