Results 31 to 40 of about 18,507 (146)

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Adipsic central diabetes insipidus as a result of neurosarcoidosis

Revista Mexicana de Endocrinología, Metabolismo y Nutrición
Sarcoidosis is a systemic multisystem inflammatory disorder of unknown etiology characterized by the presence of non-caseating granulomas. Neurosarcoidosis leads to hypothalamus- pituitary axis dysfunction, and the most common clinical manifestation is ...
Radmila Milosheska, Ivana Mickovski, Daniela Buklioska Ilijevska   +2 more
doaj   +1 more source

Estimation the activity of Copeptin, insulin, and C-peptide from patients with polycystic ovary syndrome

Tikrit Journal of Pure Science, 2018
Copeptin, the C-terminal part of the vasopressin prohormone, is secreted stoichiometrically with vasopressin that is more easily measured than Arginine vasopressin.
Entedhar R. Sarhat, Madlen Qassm Abbas
doaj   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Serum Copeptin Rises After Tolvaptan for Hyponatraemia, but Does Not Predict Risk of Rapid Sodium Rise: Pre‐Specified Secondary Analysis of the TVFR Trial

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Hyponatraemia is a common electrolyte disorder often driven by excess arginine vasopressin (AVP). Copeptin is a stable surrogate marker co‐secreted with AVP. It is unclear whether treatment of hyponatraemia with tolvaptan, an AVP‐V2 receptor antagonist, impacts copeptin.
Annabelle M. Warren, Kay Weng Choy, Rudolf Hoermann, Nicholas Russell, Mathis Grossmann   +4 more
wiley   +1 more source

Strategies for discontinuing vasopressin and norepinephrine during the recovery phase of shock: a single-center retrospective study

Journal of Intensive Care
Background The optimal strategy for discontinuing arginine vasopressin and norepinephrine in patients recovering from shock remains uncertain. Although prior studies have suggested a higher risk of hypotension when arginine vasopressin is discontinued ...
Shiho Suganuma, Shigehiko Uchino, Seiya Nishiyama, Yusuke Sasabuchi, Shinshu Katayama   +4 more
doaj   +1 more source

Use of 'Vaptans' in treatment of hyponatremia

Türk Kardiyoloji Derneği Arşivi, 2015
Hyponatremia is the most prevalent electrolyte imbalance, and may be present in up to 30% of hospitalized patients. It is an important predictor of in-hospital mortality.
Aslı Tanındı, Hasan Fehmi Töre
doaj   +1 more source

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

Haemophilia, EarlyView.
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini, Robert Klamroth, Bauke Haisma, Dino Mehic, Saskia E. M. Schols   +4 more
wiley   +1 more source

Engineered surface strategies to manage dental implant‐related infections

Periodontology 2000, EarlyView.
Abstract When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant‐related infections—one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems.
João Gabriel S. Souza, Bruna E. Nagay, Rodrigo Martins, Martinna Bertolini, Jamil A. Shibli, Conrado Aparicio, Magda Feres, Valentim A. R. Barão   +7 more
wiley   +1 more source

Arginine vasopressin and copeptin in perinatology

Frontiers in Pediatrics, 2016
Arginine vasopressin (AVP) plays a major role in the homeostasis of fluid balance, vascular tonus and the regulation of the endocrine stress response. The measurement of AVP levels is difficult due to its short half-life and laborious method of detection.
Katrina Suzanne Evers, Sven Wellmann
doaj   +1 more source