Results 41 to 50 of about 18,348 (185)

Compartmentalisation in cAMP signalling: A phase separation perspective

open access: yesBritish Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Autosomal dominant familial neurohypophyseal diabetes insipidus caused by a mutation in the arginine-vasopressin II gene in four generations of a Korean family [PDF]

open access: yesAnnals of Pediatric Endocrinology & Metabolism, 2014
Autosomal dominant neurohypophyseal diabetes insipidus is a rare form of central diabetes insipidus that is caused by mutations in the vasopressin-neurophysin II (AVP-NPII) gene.
Myo-Jing Kim   +3 more
doaj   +1 more source

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

open access: yesHaemophilia, EarlyView.
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini   +4 more
wiley   +1 more source

Platelet Levels Associated With Bleeding Risk for Dental Interventions: A Systematic Review

open access: yesOral Diseases, EarlyView.
ABSTRACT Objectives To evaluate evidence in relation to postoperative bleeding in humans aged ≥ 16 with preoperative platelet counts < 50,000/μL, compared to those above, undergoing dental interventions. Methods Quantitative synthesis without meta‐analysis was conducted through an electronic search conducted on Ovid MEDLINE and Embase from 1946 to ...
Guang Xu David Lim   +3 more
wiley   +1 more source

New Topics in Vasopressin Receptors and Approach to Novel Drugs: Research and Development of Conivaptan Hydrochloride (YM087), a Drug for the Treatment of Hyponatremia

open access: yesJournal of Pharmacological Sciences, 2009
Hyponatremia is the most common electrolyte disorder in hospitalized patients and is associated with the risk of intractable seizures and death. The effectiveness of conventional therapies for hyponatremia is inconsistent, and the rapid correction of ...
Yukinori Arai   +3 more
doaj   +1 more source

Testosterone Acts Within the Medial Amygdala of Rats to Reduce Innate Fear to Predator Odor Akin to the Effects of Toxoplasma gondii Infection

open access: yesFrontiers in Psychiatry, 2020
Rats infected with the protozoan Toxoplasma gondii exhibit a reduced aversion to cat odor. This behavioral change is thought to increase trophic transmission of the parasite. Infected male rats also show a greater testicular synthesis of testosterone and
Dhiraj Kumar Singh   +3 more
doaj   +1 more source

EFFECT OF ANGIOTENSIN-CONVERTING ENZYME INHIBITOR ENALAPRIL ON SYSTOLIC BLOOD PRESSURE OF THE CAMEL [PDF]

open access: yesAssiut Veterinary Medical Journal, 1998
The effect of Enalapril (angiotensin-converting enzyme inhibitor, ACE 1) on systolic blood pressure was studied on the Arabian camel (Camelus dromedarius). Ten camels were divided into two groups of five animals each. Group one animals were injected each
A.A. Al-Qarawi
doaj   +1 more source

Engineered surface strategies to manage dental implant‐related infections

open access: yesPeriodontology 2000, EarlyView.
Abstract When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant‐related infections—one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems.
João Gabriel S. Souza   +7 more
wiley   +1 more source

New Topics in Vasopressin Receptors and Approach to Novel Drugs: Effects of Vasopressin Receptor on Regulations of Hormone Secretion and Metabolisms of Glucose, Fat, and Protein

open access: yesJournal of Pharmacological Sciences, 2009
The neurohypophyseal peptide [Arg8]-vasopressin (AVP) is involved in diverse functions such as the regulation of body fluid homeostasis, metabolism, and hormone secretion.
Akito Tanoue
doaj   +1 more source

Pharmacologic management of nocturnal polyuria: a contemporary assessment of efficacy, safety, and progress toward individualized treatment

open access: yesTherapeutic Advances in Urology, 2021
This narrative review synthesizes current evidence on the medical management of nocturnal polyuria, including antidiuretic replacement therapy as well as other emerging modalities, with particular emphasis on areas of active investigation and future ...
Thomas F. Monaghan   +3 more
doaj   +1 more source

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