Results 61 to 70 of about 18,507 (146)

Unlocking a Nitrosuccinate Lyase for Decarboxylative Enzymatic Hydronitration

Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.
The nitrosuccinate lyase CreD catalyzes C–NO2 bond formation using nitrite in water and shows synthetic practicality with high turnover numbers up to 102,000. A combination of protein engineering and computational methods helped to reveal the mechanistic principles that underpin this unique enzymatic activity.
Matteo Aleotti, Hannah Dreisbach, Rémi Corlay, Clara Weber, Tamara Reiter, Wael Elaily, Bastian Daniel, Klaus Zangger, Pedro A. Sánchez‐Murcia, Mélanie Hall   +9 more
wiley   +2 more sources

Nephrogenic diabetes insipidus (NDI): clinical, laboratory and genetic characterization of five Brazilian patients

Clinics, 2009
INTRODUCTION: Nephrogenic diabetes insipidus is characterized by a lack of response in the distal nephron to the antidiuretic hormone arginine vasopressin.
Maria Helena Vaisbich, Juliana Carneiro, Wolfanga Bóson, Bruna Resende, Luiz De Marco, Rachel S Honjo, Chong Ae Kim, Vera H Koch   +7 more
doaj   +1 more source

Maternal glucocorticoids have persistent effects on offspring social phenotype irrespective of opportunity for social buffering

Journal of Animal Ecology, Volume 95, Issue 8, Page 1326-1338, August 2026.
This study tests whether early‐life maternal association buffers offspring from the effects of prenatal stress in a facultatively social lizard. Despite clear effects of maternal glucocorticoids on growth and social behaviour, social associations did not mitigate these effects, revealing limits to social buffering in this species.
Kirsty J. MacLeod, Alix Bouffet‐Halle, Erik Wapstra, Tobias Uller, Geoffrey M. While   +4 more
wiley   +1 more source

Pufferfish exposure and presumed tetrodotoxicosis in Australian dogs: 372 cases (2007–2018)

Australian Veterinary Journal, Volume 104, Issue 8, Page 497-508, August 2026.
Introduction Tetrodotoxin (TTX) is a neurotoxin found in pufferfish that results in the blockade of excitatory conduction and clinical signs including gastrointestinal upset and paralysis. The objectives of this study were to describe the epidemiology of pufferfish exposure and presumed tetrodotoxicosis in dogs, and to determine associations with the ...
J Hanson, CR Sharp, EM Leister
wiley   +1 more source

Biofluid Biomarkers of Cognitive Functioning in Bipolar Disorder: A Systematic Review by the Targeting Cognition and Older‐Age Bipolar Disorder ISBD Task Forces

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Background Cognitive impairment is common in bipolar disorder (BD), but the underlying pathophysiology remains unclear. This systematic review aimed to (1) summarize all literature describing relationships of biofluid biomarkers and cognition in BD and (2) identify which biofluid biomarkers correlate most consistently with cognition in BD ...
Alexandra J. M. Beunders, Sigfried N. T. M. Schouws, Andrew T. Olagunju, Vicent Balanzá‐Martínez, Nicole C. M. Korten, Ralph W. Kupka, Katherine E. Burdick, Andre F. Carvalho, Ariel G. Gildengers, Lars V. Kessing, Roger S. McIntyre, Paula V. Nunes, Ayal Schaffer, Ivan J. Torres, Shang‐Ying Tsai, Tamsyn E. Van Rheenen, Eduard Vieta, Lakshmi N. Yatham, Allan H. Young, Lisa T. Eyler, Kamilla W. Miskowiak, Annemiek Dols   +21 more
wiley   +1 more source

Effects of Tirzepatide Therapy on Arginine Vasopressin Deficiency: A Case with Reduced Desmopressin Requirement

Endocrinology Research and Practice
Arginine vasopressin deficiency (AVP-D) is a rare endocrine disorder that causes polyuria and polydipsia. The case of a 45-year-old woman with AVP-D who showed a marked reduction in urine output and desmopressin requirement after starting tirzepatide ...
Elif Yivli, Ömercan Topaloğlu
doaj   +3 more sources

Towards a Safe and Effective Lithium Therapeutic Range for Older Adults With Bipolar Disorder: An ISBD Task Force Systematic Review

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Objectives Lithium is recommended as the first‐line maintenance treatment for older adults with bipolar disorder (OABD). However, age‐related reduction in renal clearance, heightened sensitivity to adverse effects, and drug interactions increase the risk of toxicity and necessitate lower therapeutic serum levels in this population.
Paula V. Nunes, Andrew T. Olagunju, Debbie Zittema, Astha Dhyani, Lei Fu, Peijun Chen, Laura Montejo, Gabriel R. Fries, Lars V. Kessing, Eduard Vieta, Orestes V. Forlenza, Annemieke Dols, Hilary P. Blumberg, Lisa T. Eyler, Kenneth I. Shulman, on behalf of the International Society for Bipolar Disorders (ISBD) Older Adults with Bipolar Disorder (OABD) Lithium Workgroup Task Force   +15 more
wiley   +1 more source

Physiological Basis of Sex Differences in Human Performance and Exercise‐Associated Pathology

Clinical Endocrinology, Volume 105, Issue 2, Page 151-162, August 2026.
ABSTRACT The presence of sex differences in human physical performance is well‐established and shaped by distinct endocrine, anatomical and physiological mechanisms. Despite sustained advances, our understanding of how inherent biological factors drive variations in exercise capacity and related pathologies is still developing.
David A. Holdsworth, Thomas J. O'Leary, Craig L. Doig, Natalie Taylor, Jasminder Dosanjh, David R. Woods, Michael J. Stacey, Robert M. Gifford   +7 more
wiley   +1 more source

Perpendicular and transverse needling of “Sanyinjiao” (SP6) relieves abdominal pain by regulating arginine vasopressin and its receptor expression levels in uterus and hypothalamus in cold-stasis type dysmenorrhea rats

针刺研究, 2020
Objective To observe the effect of perpendicular and subcutaneous transverse needling at "Sanyinjiao"(SP6) on visceral pain behavior, arginine vasopressin(AVP) content in the serum, uterine tissues, spinal cord and hypothalamus and expression of AVP ...
SONG Yue, MA Liang-xiao, GAN Ying-ying, WANG Jun-xiang, MU Jie-dan, GUO Meng-wei, REN Xiao-xuan, YU Wen-yan, TIAN Yuan, QIAN Xu, SUN Tian-yi   +10 more
doaj  

Genetic Insights Into AVP Deficiency: Identification of a Novel AVP Variant and Compilation of a Curated Catalogue of Pathogenic Variants

Clinical Genetics, Volume 110, Issue 2, Page 203-209, August 2026.
We identified a novel pathogenic AVP variant in two Danish families with autosomal dominant inheritance of symptoms of AVP deficiency. In addition, we compiled a catalogue of additionally 109 AVP variants that cause AVP deficiency and demonstrated the advantage of combining expert‐assisted curation, literature search, and online repositories to ensure ...
Jennifa Joseph, Esben Søndergaard, Sine Knorr, Jane Hagelskjær Knudsen, Søren Rittig, Jane Hvarregaard Christensen   +5 more
wiley   +1 more source