Results 161 to 170 of about 110,455,116 (191)

Argininosuccinate Synthetase Activity in Cultured Human Lymphocytes [PDF]

Biochemical Genetics, 1977
The activity of argininosuccinate synthetase (E.C. 6.3.4.5), a urea cycle enzyme, was measured in cultured human lymphocytes using a new radioactive assay. Control cells had a maximum specific activity of 15.7±8.7 nmoles per hour per milligram of protein
A D Bloom, Elaine B Spector
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Computational investigation on the effect of the lysine 2-hydroxyisobutyrylation on argininosuccinate synthetase 1 conformational dynamics in Botrytis cinerea

Journal of Molecular Modeling, 2022
Lysine 2-hydroxyisobutyrylation (Khib) is a newly discovered post-translational modification in recent years, which has been identified in several species and is associated with diverse cellular functions. Botrytis cinerea, as a broad host pathogen, is very destructive and causes serious losses to agricultural economy. Argininosuccinate synthetase (ASS,
Ruihan, Wu, Juan, Du
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Argininosuccinate synthetase 1 contributes to gastric cancer invasion and progression by modulating autophagy

The FASEB Journal, 2018
Argininosuccinate synthetase 1 (ASS1) is a rate‐limited enzyme in arginine biosynthesis. The oncogenic potential of ASS1 in terms of prognosis and cancer metastasis in arginine prototrophic gastric cancer (GC) remains unclear at present.
Chung-Ying, Tsai, Hsiang-Cheng, Chi, Lang-Ming, Chi, Huang-Yu, Yang, Ming-Ming, Tsai, Kam-Fai, Lee, Hsiang-Wei, Huang, Li-Fang, Chou, Ann-Joy, Cheng, Chih-Wei, Yang, Chia-Siu, Wang, Kwang-Huei, Lin   +11 more
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Mild citrullinemia in Caucasians is an allelic variant of argininosuccinate synthetase deficiency (citrullinemia type 1)

Molecular Genetics and Metabolism, 2003
Citrullinemia is caused by either deficiency of argininosuccinate synthetase (ASS, citrullinemia type 1) or a defect of the SLC25A13 gene encoding a mitochondrial aspartate-glutamate transporter (citrullinemia type II). Citrullinemia type 1-referred to as classical citrullinemia-is characterized by largely elevated concentrations of citrulline ...
Johannes, Häberle, Silke, Pauli, Eva, Schmidt, Barbara, Schulze-Eilfing, Christoph, Berning, Hans Georg, Koch   +5 more
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A regulatory role of Kruppel-like factor 4 in endothelial argininosuccinate synthetase 1 expression in response to laminar shear stress

Biochemical and Biophysical Research Communications, 2012
Endothelial argininosuccinate synthetase 1 (ASS1) regulates the provision of l-arginine to nitric oxide synthase 3 (NOS3). Previous studies demonstrated that endothelial ASS1 expression was induced by laminar shear stress (LSS) and that this enzyme plays a role in maintaining anti-inflammatory microenvironments through enhancing NO production. However,
Gyeong In, Mun, Yong Chool, Boo
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New chromosomal mapping assignments for argininosuccinate synthetase pseudogene 1, interferon-?3 gene, and the diazepam binding inhibitor gene

Somatic Cell and Molecular Genetics, 1992
Argininosuccinate synthetase pseudogene 1 (ASSP1), interferon-beta 3 (IFNB3) gene, and diazepam binding inhibitor (DBI) gene have previously been mapped to human chromosome 2. Their nucleotide sequences, recorded in the GENBANK data base, were used to generate DNA primers to amplify specific sequences using the polymerase chain reaction (PCR).
S, Todd, S L, Naylor
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Argininosuccinate Synthetase-1 (ASS1) Loss in High-Grade Neuroendocrine Carcinomas of the Urinary Bladder: Implications for Targeted Therapy with ADI-PEG 20

Endocrine Pathology, 2018
High-grade neuroendocrine carcinomas (HGNECs) of the urinary bladder encompass small cell (SCNEC) and large cell neuroendocrine carcinomas (LCNEC). Currently, recommended initial management is with systemic chemotherapy, followed by consolidative therapy with either radical cystectomy or radiotherapy in patients with localized disease.
Sounak, Gupta, Divya, Sahu, John S, Bomalaski, Igor, Frank, Stephen A, Boorjian, Prabin, Thapa, John C, Cheville, Donna E, Hansel   +7 more
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FUNCTIONAL COMPLEMENTATION OF AN ARGININE AUXOTROPHIC YEAST MUTANT BY AN ARGININOSUCCINATE SYNTHETASE FROM PORPHYRA YEZOENSIS (RHODOPHYTA)¹

Journal of Phycology, 2006
The objective of this study was to develop a tool for studying Porphyra yezoensis Ueda gene function using the yeast transformation system. The gene encoding argininosuccinate synthetase (EC 6345) of P. yezoensis (PyARG1) was obtained by PCR using an expressed sequence tag clone as a template, and subcloned into the yeast expression vector pYES2.
Hirotoshi Endo, Shuuji Ootsuka, Satoru Fukuda, Yukihiro Kitade, Naotsune Saga   +4 more
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Inducible nitric oxide synthase and argininosuccinate synthetase: co-induction in brain tissue of patients with Alzheimer's dementia and following stimulation with β-amyloid 1–42 in vitro

Neuroscience Letters, 2002
In Alzheimer's disease (AD), amyloid plaques within the brain are surrounded by activated glial cells (microglia and astrocytes). The mechanisms of glial activation and its effect on disease progression are not fully understood. Growing evidence suggests that beta-amyloid (Abeta) peptide, a major constituent of the amyloid plaque, is critically ...
Jürgen, Haas, Brigitte, Storch-Hagenlocher, Annette, Biessmann, Brigitte, Wildemann   +3 more
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Methods for treating breast and other cancers by targeting argininosuccinate synthetase 1-deficiency

2022
ANN DAVID K, CHEN YUN-RU, QIU FUMING
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