Results 181 to 190 of about 7,615 (291)

Why First-Hand Accounts From Nursing Assistants Matter? Methodological Reflections on a Role Theory-Informed Qualitative Study [Response to Letter]. [PDF]

J Multidiscip Healthc
Song A, Yan X, Yao L, Shao M, Zhou H, Zhou N, Si H, Zhou J, Li X, Li Y.   +9 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

When AI Colludes: Clinical Reliability of Training and Preference Data as a Trustworthy-AI Criterion. [PDF]

JMIR Ment Health
Tahseen H.
europepmc   +1 more source

Effect of Argument-Driven Inquiry Instruction Model on Biology Achievement, Analytical Thinking and Instructional Satisfaction of Grade 10 Students พาอี [PDF]

วิทยานิพนธ์ (ศษ.ม.(การสอนวิทยาศาสตร์และคณิตศาสตร์))--มหาวิทยาลัยสงขลานครินทร์,2561การวิจัยครั้งนี้ศึกษาผลของการจัดการเรียนรู้ด้วยรูปแบบการสืบเสาะแบบมีการโต้แย้งที่มีต่อผลสัมฤทธิ์ทางการเรียนชีววิทยา การคิดวิเคราะห์ และความพึงพอใจต่อการจัดการเรียนรู้ของน ...
พาอีหม๊ะ, เจะสา
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Aligning AI affordances with critical thinking skills in Chinese EFL: a discrepancy-based needs analysis for an AI-integrated blended reading module. [PDF]

Front Psychol
Yang A, Dong L.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Too deductive too soon? Toward an inductive renewal of implementation science. [PDF]

Implement Sci
Nilsen P, Kislov R, Birken SA, Mittman BS.   +3 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Aristotle's intuitionist approach to morality guides a new direction in moral psychology. [PDF]

Humanit Soc Sci Commun
Amormino P, Law KF, Inbar Y.
europepmc   +1 more source