Results 61 to 70 of about 1,332,288 (370)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

الحجاج البلاغي في تفسير المحرر الوجيز لابن عطية الأندلسي (ت 541 ه) – دراسة تحليلية

مجلة كلية العلوم الأسلامية
The term "rhetorical argumentation" represents one of the most important modern approaches in the study of texts, marking a mature and advanced stage in contemporary pragmatic studies. Building on this foundation, the research explores the key rhetorical
عدنان جاسم محمّد الجميلي
doaj   +1 more source

Argument Pedagogy for Everyday Life

Journal of Communication Pedagogy, 2019
This article assists argumentation and debate instructors in developing courses that provide coverage of foundational concepts while reflecting their own interests.
Jeffrey P. Mehltretter Drury, Nicholas S. Paliewicz, Sara A. Mehltretter Drury   +2 more
doaj   +1 more source

Professional Learning Portfolios for Argumentation in School Science [PDF]

, 2008
This paper reports on the use of portfolios in a continuing professional development programme to advance teachers’ skills in their pedagogy of argumentation.
Simon, Shirley, Johnson, Sue, Johnson, Susan   +2 more
core   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Contemporary prolepsis in digital rhetoric: the roles and functions of proleptic cues

Res Rhetorica
This article explores the adaptation of Gérard Genette's concept of narrative prolepsis in the realm of social media as the proleptic technique, demonstrating its effectiveness as a tool for anticipatory rhetoric in digital communication.
Alina Landowska, Andrea Rocci, Marcin Koszowy   +2 more
doaj   +1 more source

Professional development programs to improve science teachers’ skills in the facilitation of argumentation in science classroom—a systematic review

Disciplinary and Interdisciplinary Science Education Research, 2023
Argumentation is crucial to fostering scientific reasoning and problem-solving in science education. However, researchers and teachers still report problems facilitating argumentation in the classroom.
Raphael Wess, Burkhard Priemer, Ilka Parchmann   +2 more
doaj   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Actions that contribute to science teaching involving argumentation and their relationships with pedagogical content knowledge

Investigações em Ensino de Ciências, 2022
In argumentation-based science teaching, teachers play an important role and are the main party responsible for the introduction of argumentation in classrooms.
Stefannie de Sá Ibraim, Rosária Justi
doaj   +1 more source