Results 81 to 90 of about 79,506 (261)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Ensaio Pesquisa em Educação em Ciências (Belo Horizonte), 2013 Ibraim, Stefannie de Sá +1 more
openaire +4 more sources
Efficient Quantum Polar Coding
, 2012 Polar coding, introduced 2008 by Arikan, is the first (very) efficiently encodable and decodable coding scheme whose information transmission rate provably achieves the Shannon bound for classical discrete memoryless channels in the asymptotic limit of ...
E. Sasoglu +7 more
core +1 more source
Argumentation Schemes for Blockchain Deanonymisation
FinTechCryptocurrency forensics have become standard tools for law enforcement. Their basic idea is to deanonymise cryptocurrency transactions to identify the people behind them. Cryptocurrency deanonymisation techniques are often based on premises that largely remain implicit, especially in legal practice.
Dominic Deuber +4 more
openaire +4 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Why Fallacies Appear to be Better Arguments Than They Are
Informal Logic, 2010 This paper offers a solution to the problem of understanding how a fallacious argument can be deceptive by “seeming to be valid”, or (better) appearing to be a better argument of its kind than it really is.
Douglas Walton
doaj +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Les belles idées de la défigurée : à propos du plateau labial des Mursi (Ethiopie)
Images Re-Vues, 2012 The Mursi lip-plate is usually seen as a disappearing sign of backwardness. Beyond a counter argumentation on the stereotypes, I will try to show that the lip-plate has several modes of action, all within the praxis of the body to which it is integral ...
Jean-Baptiste Eczet
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
On Complex Argumentation Structures in Tweets
Argumentation et Analyse du DiscoursUsing a corpus of all tweets issued by German members of parliament in a recent 6-year period, we study the formal complexity of the argumentation found in tweet pairs, where the second is a reply to the first.
Robin Schaefer +2 more
doaj +1 more source