Results 81 to 90 of about 4,778 (312)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

The Application of Socioscientific Issues (SSI)-Based Learning to Develop Scientific Argumentation Skills in the Production of Bio-foam (Biodegradable Styrofoam) from Sugarcane Bagasse

open access: yesSEAQIS Journal of Science Education
SSI-based learning focuses on the complex problems that develop throughout society. SSI holds significant implications for society, requiring students, as the future generation, to actively participate in dialogue, discussion, debate, and argumentation ...
Nurul Qomariah
doaj   +1 more source

Assessing Argumentation Skills

open access: yes
Skills of argument have attracted the attention of educators but remain challenging to both assess and develop. In contrast to the traditional essay, dialogic argument requires reflection on and coordination of one’s own claims with those of an interlocutor.
openaire   +2 more sources

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

open access: yesFEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc   +8 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Explicit argumentation instruction to facilitate conceptual understanding and argumentation skills

open access: yesResearch in Science & Technological Education, 2013
Background: Argumentation is accepted by many science educators as a major component of science education. Many studies have investigated students’ conceptual understanding and their engagement in argumentative activities. However, studies conducted in the subject of chemistry are very rare.Purpose: The present study aimed to investigate the effects of
openaire   +2 more sources

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

open access: yesFEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

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