Results 91 to 100 of about 8,352 (302)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Improving Argumentative Skills in Education: Three Online Discussion Tools [PDF]
, 2021 How can we foster sound argumentation and valid criticism in education? How to help students to avoid fallacies, resist polarization, respond wisely to misleading information, and how to make them produce arguments that are genuinely responsive to the position of those they address?
openaire +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Argumentation as a pathway to critical thinking [PDF]
, 2019 Based on insights from the field of educational psychology, we designed and implemented an eightweek, small-scale intervention for first year university students in educational sciences.
Bubikova-Moan, Jarmila +1 more
core +2 more sources
An argument for reviving the disappearing skill of cardiac auscultation
Cleveland Clinic Journal of Medicine, 2012 Three case scenarios show how the clinical examination can complement echocardiography in the evaluation of valvular heart disease.
Donald, Clark +4 more
openaire +2 more sources
Fostering university freshmen's mathematical argumentation skills with collaboration scripts
, 2020 Students often have problems formulating und using arguments in mathematical contexts. Therefore, we investigated to what extent a collaboration script helps students overcome their problems and acquire mathematical argumentation skills.
Reiss, Kristina +4 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Using Toulmin’s Argument Pattern in the evaluation of argumentation in school science [PDF]
, 2008 Toulmin's definition of argument has been used by researchers as a theoretical perspective on argument and as a methodological tool for analysing episodes of oral argumentation.
Simon, Shirley
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
, 2014 :Learning Biology through Argument-Driven Inquiry Strategies and Argumentation Skills ofStudent. Argumentation skills as a form of communication to externalise ideas through scientific discourseis a very important process in learning biology.
Hasnunidah, Neni
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