Results 91 to 100 of about 2,154,157 (294)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
LOOKING AT A PORTRAIT OF STUDENT ARGUMENTATION SKILLS ON THE CONCEPT OF INHERITANCE (21ST CENTURY SKILLS STUDY) [PDF]
, 2020 This research was conducted to obtain a picture of the level of argumentation skills of students in science learning. This research is a starting point to find out the level of 21st century skills that are very important students have, one of which is ...
Fadly, Wirawan +1 more
core +1 more source
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2020 : Argumentation is an important activity in scientific exploration which has been agreed as a major component in science education. Quality argumentation skills are formed with the understanding of concepts owned by students.
Astrid Kinantya Paramita +2 more
doaj +1 more source
Primary school students’ argumentation skills: expression of arguments
Problemy Wczesnej Edukacji, 2019 This study was conducted to analyze the fourth grade students’ linguistic abilities allowing them to express their arguments in oral and written texts: to determine both the number of presented arguments as well as the level of their elaboration, to characterize the expression of the arguments. The recorded number of participants was 117 fourth-graders
openaire +4 more sources
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
An argument for reviving the disappearing skill of cardiac auscultation
Cleveland Clinic Journal of Medicine, 2012 Three case scenarios show how the clinical examination can complement echocardiography in the evaluation of valvular heart disease.
Donald, Clark +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source