Results 41 to 50 of about 9,406 (295)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Analogical Argument Schemes and Complex Argument Structure

Informal Logic, 2015
This paper addresses several issues in argumentation theory. The over-arching goal is to discuss how a theory of analogical argument schemes fits the pragma-dialectical theory of argument schemes and argument structures, and how one should properly ...
Andre Juthe
doaj   +3 more sources

Argumentationsanalyse. Grundtræk af en modulær sprogvidenskabelig tilgang

Hermes, 1998
In this article, the author presents some fundamentals of a modular linguistic approach to argumentation. Argumentation is seen as a matter of interpretation, and since interpretation phenomena depend on linguistic material as well as on context in the ...
Henning Nølke
doaj   +1 more source

The hole argument for covariant theories [PDF]

General Relativity and Gravitation, 2006
The hole argument was developed by Einstein in 1913 while he was searching for a relativistic theory of gravitation. Einstein used the language of coordinate systems and coordinate invariance, rather than the language of manifolds and diffeomorphism invariance.
Iftime, M., Stachel, J.
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Useful Argumentation: A Critique of the Epistemological Approach

Informal Logic, 2005
The main rationale for adopting the epistemological approach to argumentation seems to take the form of a criticism of the consensus theory. This criticism says that some instances of clearly bad argumentation count as acceptable instances of ...
Brian Huss
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Correction to: Schumpeter’s business cycle theory and the diversification argument [PDF]

, 2021
Vipin P. Veetil
openalex   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Modal Criterion for Epistemic Argumentation

Informal Logic, 2022
In this paper, I spell out and argue for a new epistemic theory of argumentation. Contrary to extant views, this theory is compatible with a pluralistic framework on argumentation, where the norms governing argumentation depend on the aim with which we ...
Job de Grefte
doaj