Results 61 to 70 of about 246,980 (329)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Introduction: The Epistemological Approach to Argumentation--A Map

Informal Logic, 2005
An overview of the epistemological approach to argumentation, explaining what it is, justifying it as better than a rhetorical or a consensual ist approach. systematizing the main directions and theories according to their criteria for good argumentation
Christoph Lumer
doaj   +1 more source

Strategic Manoeuvering in 2019 Campaign Speeches in the Eastern Cape Province in South Africa: Extended Pragma-Dialectical Perspective

Modern Africa, 2023
This article investigates how political candidates in the Eastern Cape Province in South Africa employed means of strategic manoeuvring during the provincial election campaigns of 2019.
Zameka Paula Sijadu, Gaspardus Mwombeki
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Teisinis samprotavimas: argumentacinis metodologinis požiūris

Teisė, 2009
Teisinis argumentavimas, samprotavimas, teisės aiškinimas – susiję, sutampantys, o kartais tapatinami teise grįsto sprendimo priėmimo proceso aspektai. Lietuviškoje teisės doktrinoje plačiau analizuojama teisės aiškinimo, interpretavimo problematika, o ...
Eglė Mackuvienė
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Michael A. Gilbert: Not arguing logically is not illogical: Other ways of communicating arguments

Argumentation et Analyse du Discours
Michael A. Gilbert has contributed significantly to the field of contemporary Argumentation Theory. Most notable are his multi-modal theory of argumentation and coalescent argumentation, models of argument that he developed to address how interlocutors ...
Michael A. Gilbert, Linda Carozza
doaj   +1 more source

A World of Difference: The Rich State of Argumentation Theory

Informal Logic, 1995
This paper surveys the contributions to the study of argumentation in the two decades since the work of Toulmin and Perelman. Developments include Radical Argumentativism (Anscombre and Ducot), Communication and Rhetoric (American Speech Communication ...
Frans H. van Eemeren
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

A Simple Theory of Argument Schemes

Informal Logic, 2021
While there has been in depth discussion of many particular argumentation schemes, some lament that there is little to no theory underpinning the notion of an argumentation scheme. Here I shall argue against the utility of argument schemes, at least as a
Geoff Goddu
doaj