Results 41 to 50 of about 2,142 (181)

The Disturbance of Hepatic and Serous Lipids in Aristolochic Acid Ι Induced Rats for Hepatotoxicity Using Lipidomics Approach

Molecules, 2019
Aristolochic acid I (AAI) was regarded as the major toxic component of aristolochic acid (AA). In addition to aristolochic acid nephropathy (AAN), liver cancers induced by AAI has aroused increasing attention recently.
Junyi Zhou, Yifei Yang, Hongjie Wang, Baolin Bian, Jian Yang, Xiaolu Wei, Yanyan Zhou, Nan Si, Haiyu Zhao   +8 more
doaj   +1 more source

Integration of Transcriptomic and Metabolomic Data to Compare the Hepatotoxicity of Neonatal and Adult Mice Exposed to Aristolochic Acid I

Frontiers in Genetics, 2022
Aristolochic acid (AA) is a group of structurally related compounds what have been used to treat various diseases in recent decades. Aristolochic acid I (AAI), an important ingredient, has been associated with tumorigenesis.
Zhi-e Fang, Zhi-e Fang, Zhi-e Fang, Chunyu Wang, Chunyu Wang, Ming Niu, Ming Niu, Tingting Liu, Tingting Liu, Lutong Ren, Lutong Ren, Qiang Li, Qiang Li, Zhiyong Li, Zhiyong Li, Ziying Wei, Ziying Wei, Li Lin, Li Lin, Wenqing Mu, Wenqing Mu, Yuan Gao, Xiaohe Xiao, Xiaohe Xiao, Xiaohe Xiao, Zhaofang Bai, Zhaofang Bai   +26 more
doaj   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Harpalycin 2 inhibits the enzymatic and platelet aggregation activities of PrTX-III, a D49 phospholipase A₂ from Bothrops pirajai venom

BMC Complementary and Alternative Medicine, 2012
Background Harpalycin 2 (HP-2) is an isoflavone isolated from the leaves of Harpalyce brasiliana Benth., a snakeroot found in northeast region of Brazil and used in folk medicine to treat snakebite. Its leaves are said to be anti-inflammatory.
Ximenes Rafael M, Alves Renata S, Pereira Ticiana P, Araújo Renata M, Silveira Edilberto R, Rabello Marcelo M, Hernandes Marcelo Z, Soares Veronica C G, Bristot Daniel, Pires Camila L, Toyama Daniela O, Gaeta Henrique H, Monteiro Helena S A, Toyama Marcos H   +13 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Periodontitis and high phosphate intake alone or in combination adversely affect the kidney

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis and high phosphate (HP) intake can negatively affect the kidney in the presence of renal disease. This study aimed to evaluate the effects of periodontitis or HP intake, either alone or concurrently, on the periodontal tissue and the kidney under normal renal conditions.
Ae Ri Kim, Min Seo Kim, Jiwon Seo, Eun‐Jung Bak, Yun‐Jung Yoo   +4 more
wiley   +1 more source

Aristolochic acid-associated urothelial cancer in Taiwan [PDF]

Proceedings of the National Academy of Sciences, 2012
Aristolochic acid, a potent human carcinogen produced by Aristolochia plants, is associated with urothelial carcinoma of the upper urinary tract (UUC). Following metabolic activation, aristolochic acid reacts with DNA to form aristolactam (AL)-DNA adducts.
Chung-Hsin, Chen, Kathleen G, Dickman, Masaaki, Moriya, Jiri, Zavadil, Viktoriya S, Sidorenko, Karen L, Edwards, Dmitri V, Gnatenko, Lin, Wu, Robert J, Turesky, Xue-Ru, Wu, Yeong-Shiau, Pu, Arthur P, Grollman   +11 more
openaire   +2 more sources

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Recognition of the toxicity of aristolochic acid [PDF]

Journal of Clinical Pharmacy and Therapeutics, 2018
Aristolochic acid (AA) is an abundant compound in Aristolochia plants and various natural herbs. In the 1990s, a slimming formula used in Belgium that contains Aristolochia fangchi was reported to cause kidney damage and bladder cancer, and aristolochic acid nephropathy (AAN) is now well recognized worldwide. In October 2017, researchers reported an AA
Hong-Mei, Zhang, Xiao-Hu, Zhao, Zhi-Hui, Sun, Gui-Chen, Li, Guang-Chen, Liu, Li-Rui, Sun, Ji-Qiu, Hou, Wei, Zhou   +7 more
openaire   +2 more sources

Linkage disequilibrium score regression identifies genetic correlations between hepatocellular carcinoma and clinically relevant traits

International Journal of Cancer, Volume 158, Issue 5, Page 1193-1203, 1 March 2026.
What's New? Hepatocellular carcinoma arises from a combination of environmental and genetic factors, with the latter playing a potentially more significant role in nonviral hepatocellular carcinoma. Here, the authors characterized the genetic correlations and heritability between nonviral hepatocellular carcinoma and 901 epidemiologic, behavioral, and ...
Younghun Han, Vikram R. Shaw, Jinyoung Byun, Aaron P. Thrift, Catherine Zhu, Donghui Li, Rikita I. Hatia, Robin Kate Kelley, Sean P. Cleary, Anna S. Lok, Paige M. Bracci, Jennifer B. Permuth, Roxana Bucur, Jennifer Knox, Jian‐Min Yuan, Amit G. Singal, Prasun K. Jalal, R. Mark Ghobrial, Yuko Kono, Dimpy P. Shah, Mindie H. Nguyen, Neehar D. Parikh, Richard Kim, Hui‐Chen Wu, Hashem El‐Serag, Ping Chang, Yun Shin Chun, Jian Gu, Chad Huff, Asif Rashid, Lu‐Yu Hwang, Alison P. Klein, Saira A. Khaderi, Ahmed O. Kaseb, Kathrine A. McGlynn, Lewis R. Roberts, Manal M. Hassan, Christopher I. Amos   +37 more
wiley   +1 more source