Results 21 to 30 of about 2,520,275 (163)

Delineation of renal protein profiles in aristolochic acid I-induced nephrotoxicity in mice by label-free quantitative proteomics [PDF]

open access: yesFrontiers in Pharmacology
Introduction: Aristolochic acid nephropathy (AAN) is a kidney injury syndrome caused by aristolochic acids exposure. Our study used label-free quantitative proteomics to delineate renal protein profiles and identify key proteins after exposure to ...
Xinhui Liu   +11 more
doaj   +2 more sources

Aristolochic acid induces acute kidney injury through ferroptosis [PDF]

open access: yesFrontiers in Pharmacology
Aristolochic acid (AA)-induced acute kidney injury (AKI) presents with progressive decline in renal function and rapid progression to end-stage renal disease.
Xuan Huang   +13 more
doaj   +2 more sources

Aristolochic Acid Nephropathy: The Hong Kong Perspective [PDF]

open access: yes, 2007
Aristolochic acid nephropathy (AAN) is a progressive tubulointerstitial nephropathy attributed to aristolochic acid (AA) toxicity. Five cases of AAN have been diagnosed in Hong Kong.
Poon, Wing-Tat   +2 more
core   +1 more source

Short-term toxicity of aristolochic acid, aristolochic acid-I and aristolochic acid-II in rats [PDF]

open access: yes, 2010
[[abstract]]We compared the short-term toxicity of toxic components of aristolochic acid in rats. Twenty-four female Wistar rats were divided into 4 groups and treated orally every 3-days with 10 mg/kg each of aristolochic acid, aristolochic acid-I and ...
Yen-Hung Yeh;Ya-Ting Lee;Hung-Sheng Hsieh;Deng-Fwu Hwang
core   +2 more sources

Identification of a Reduction Product of Aristolochic Acid: Implications for the Metabolic Activation of Carcinogenic Aristolochic Acid

open access: yes, 2016
Aristolochic acids are nephrotoxic and carcinogenic natural products that have been implicated both in endemic nephropathy in the Balkan region and in ailments caused by ingestion of herbal remedies.
J. Martin E. Quirke (2241556)   +2 more
core   +2 more sources

Interactions of Human Organic Anion Transporters With Aristolochic Acids

open access: yesJournal of Pharmacological Sciences, 2010
Aristolochic acids (AAs), contained in Chinese herbal preparations, have been considered to induce nephropathy. In order to elucidate the molecular mechanisms of AA-induced nephrotoxicity, we have elucidated the interaction of human organic anion ...
Ellappan Babu   +8 more
doaj   +1 more source

In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging

open access: yesActa Pharmaceutica Sinica B, 2020
Understanding of the nephrotoxicity induced by drug candidates is vital to drug discovery and development. Herein, an in situ metabolomics method based on air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI) was ...
Zhonghua Wang   +7 more
doaj   +1 more source

Aristolochic acid nephropathy - still real danger

open access: yesJournal of Education, Health and Sport, 2022
Arystolocholic acid nephropathy is chronic kidney disease caused by the use of substances of natural origin that contain arystolocholic acid. The effects of their use are arystolochic acid nephropathies, which include "Chinese Herbs" nephropathy.
Rafal Oleszczuk   +4 more
doaj   +1 more source

Aristolochic acids affect the feeding behaviour and development of Battus polydamas archidamas larvae (Lepidoptera: Papilionidae: Troidini)

open access: yesEuropean Journal of Entomology, 2009
The feeding behaviour of specialist butterflies may be affected by the mechanical and chemical characteristics of the tissues of their host-plants. Larvae of the butterfly, Battus polydamas archidamas feed only on Aristolochia chilensis, which contains ...
Carlos F. PINTO   +3 more
doaj   +1 more source

Aristolochic acid causes albuminuria by promoting mitochondrial DNA damage and dysfunction in podocyte. [PDF]

open access: yesPLoS ONE, 2013
Aristolochic acid nephropathy, initially found in patients intaking of slimming herbs containing aristolochic acid (AA), was previously considered as a progressive renal interstitial fibrosis and urothelial malignancy.
Yang Zhou   +5 more
doaj   +1 more source

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