Results 61 to 70 of about 15,999 (168)

Engineering and Characterization of a Fluorescent Fission Yeast Arp2/3 Complex for Single Molecule Mechanistic Investigations

Cytoskeleton, EarlyView.
ABSTRACT Arp2/3 complex is a seven‐component protein complex that facilitates the assembly of branched actin filament networks by binding to pre‐existing “mother” actin filaments and initiating the nucleation of new branched “daughter” filaments. Arp2/3 complex must be activated by a nucleation promoting factor such as the WASP/Scar protein family. The
Caitlin A. Anderson, Meghan E. O'Connell, Kaitlin E. Homa, Cristian Suarez, Michael L. James, Kashmeera D. Baboolall, Vilmos Zsolnay, Vladimir Sirotkin, David R. Kovar   +8 more
wiley   +1 more source

Wnt/Wingless signaling through β-catenin requires the function of both LRP/Arrow and frizzled classes of receptors

BMC Cell Biology, 2003
Background Wnt/Wingless (Wg) signals are transduced by seven-transmembrane Frizzleds (Fzs) and the single-transmembrane LDL-receptor-related proteins 5 or 6 (LRP5/6) or Arrow. The aminotermini of LRP and Fz were reported to associate only in the presence
Varmus Harold, Schweizer Liang
doaj   +1 more source

Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model

Developmental Dynamics, EarlyView.
Abstract Background Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non‐canonical Wnt signaling.
Gamze Akarsu, Katja R. MacCharles, Kenneth Kin Lam Wong, Joy M. Richman, Esther M. Verheyen   +4 more
wiley   +1 more source

Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast Differentiation.

PLoS ONE, 2016
Tooth morphogenesis is initiated by reciprocal interactions between the ectoderm and neural crest-derived mesenchyme, and the Wnt signaling pathway is involved in this process.
Kanako Miyazaki, Keigo Yoshizaki, Chieko Arai, Aya Yamada, Kan Saito, Masaki Ishikawa, Han Xue, Keita Funada, Naoto Haruyama, Yoshihiko Yamada, Satoshi Fukumoto, Ichiro Takahashi   +11 more
doaj   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

SILAC-based proteomic quantification of chemoattractant-induced cytoskeleton dynamics on a second to minute timescale [PDF]

, 2014
Cytoskeletal dynamics during cell behaviours ranging from endocytosis and exocytosis to cell division and movement is controlled by a complex network of signalling pathways, the full details of which are as yet unresolved.
A Bagorda, A Kortholt, A Kortholt, A Para, A Shevchenko, AJ Saldanha, AT Sasaki, C Orelio, CL Chen, CL Manahan, DM Veltman, DM Veltman, DM Veltman, EC Rericha, EL de Hostos, F Friedberg, F Vazquez, G Vlahou, H Cai, H Kae, HR Bourne, I Marin, J Condeelis, J Cox, J Faix, J Riedl, J Schindelin, J Yan, JF Cote, JF Cote, JW Han, JY Kim, KF Swaney, L Bosgraaf, L Bosgraaf, L Bosgraaf, L Chen, M Affolter, M Brenner, M de la Roche, M Patel, MJ de Hoon, MK Vartiainen, MR Lee, MS Boguski, N Ibarra, N Meller, OD Weiner, R Insall, RH Insall, RJ Eddy, S Hanna, S Levi, SE Ong, SJ Allen, SL Blagg, TJ Jeon, WN van Egmond, X Xu, Y Yang, YC Wu   +60 more
core   +3 more sources

Expression of p120-Catenin Isoforms Correlates with Genomic and Transcriptional Phenotype of Breast Cancer Cell Lines

Cellular Oncology, 2007
Background: P120-catenin is a member of the Armadillo protein family, which is involved in intercellular adhesion and cell signalling. It directly interacts with the classical cadherins juxtamembrane domain and contributes for both junction formation and
Joana Paredes, Ana Luísa Correia, Ana Sofia Ribeiro, Fernando Schmitt   +3 more
doaj   +1 more source

Hsp70 diversification and repurposing across the tree of life: Lessons from the evolutionary and mechanistic trajectory of the Hsp70–Hsp110 chaperone system

The FEBS Journal, EarlyView.
Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co‐chaperones such as JDPs and NEF, forming increasingly complex proteostasis networks.
Pierre Goloubinoff, Paolo De Los Rios, Mathieu E. Rebeaud   +2 more
wiley   +1 more source

Dynamic changes in ANGUSTIFOLIA3 complex composition reveal a growth regulatory mechanism in the maize leaf [PDF]

, 2015
Most molecular processes during plant development occur with a particular spatio-temporal specificity. Thus far, it has remained technically challenging to capture dynamic protein-protein interactions within a growing organ, where the interplay between ...
Aesaert, Stijn, Candaele, Jasper, De Block, Jolien, De Jaeger, Geert, Demuynck, Kirin, Eeckhout, Dominique, Gevaert, Kris, Goormachtig, Sofie, Inzé, Dirk, Muszynski, Michael, Nelissen, Hilde, Persiau, Geert, Van Bel, Michiel, Van Leene, Jelle, Van Lijsebettens, Maria, Vandepoele, Klaas, Vervoort, Marieke, Walton, Alan   +17 more
core   +2 more sources

A new LRRK2 variant in a family with Parkinson’s disease affects binding to RAB8A

npj Parkinson's Disease
Pathogenic variants in the LRRK2 gene affecting catalytic domains are the most common genetic cause of Parkinson’s disease (PD). Nevertheless, LRRK2 variants at the armadillo (ARM) domain would indirectly affect the protein’s activity by interacting with
Lydia Vela-Desojo, Alba Pascual, Victor Montal, Carmen Guerrero, Mireia Osuna-López, Victor Guallar, Francesc Palau, Janet Hoenicka   +7 more
doaj   +1 more source