Results 51 to 60 of about 15,999 (168)

35 Individuals With HUWE1‐Related Neurodevelopmental Disorder and Suggested Clinical Evaluations

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT HUWE1 (HECT, UBA, and WWE Domain Containing E3 Ubiquitin Protein Ligase1, OMIM 300697), located at Xp11.22, encodes a ubiquitin ligase that is highly conserved across species. Genetic variants in HUWE1 described in multiple independent studies cause X‐linked intellectual disability, including in the patients identified by Juberg, Marsidi, and ...
Mindy H. Li, Deziree L. Coleman, Kelsey Hogan, Danielle Luz, Lindsay Bhandari, Newell Belnap, Tiffany Busa, Charles Coutton, Klaus Dieterich, Svetlana Gorokhova, Clara Hildebrandt, Rachel Logan, Milena Mariani, Manuela Morleo, Vincenzo Nigro, John Pappas, Rachel Rabin, Kelly Schoch, Angelo Selicorni, Vandana Shashi, Rebecca Spillmann, Jennifer Sullivan, Charlotte Tardy, Samantha A. Schrier Vergano, Brock Grill, Kristin Baranano   +25 more
wiley   +1 more source

Beyond mammals: the evolution of chewing and other forms of oropharyngeal food processing in vertebrates

Biological Reviews, EarlyView.
ABSTRACT Oropharyngeal food processing exhibits a remarkable diversity among vertebrates, reflecting the evolution of specialised ‘processing centres’ associated with the mandibular, hyoid, and branchial arches. Although studies have detailed various food‐processing strategies and mechanisms across vertebrates, a coherent and comprehensive terminology ...
Daniel Schwarz, Maja Mielke, Stephan Handschuh, Anthony Herrel, Patrick Lemell, Léa Da Cunha, Nicolai Konow   +6 more
wiley   +1 more source

CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium. [PDF]

, 1995
Cdc42 and Rac1 are members of the rho family of small guanosinetriphosphatases and are required for a diverse set of cytoskeleton-membrane interactions in different cell types.
Auvinen, P, Eaton, S, Jan, YN, Luo, L, Simons, K   +4 more
core  

A Flagellar A-Kinase Anchoring Protein with Two Amphipathic Helices Forms a Structural Scaffold in the Radial Spoke Complex [PDF]

, 2012
A-kinase anchoring proteins (AKAPs) contain an amphipathic helix (AH) that binds the dimerization and docking (D/D) domain, RIIa, in cAMP-dependent protein kinase A (PKA). Many AKAPs were discovered solely based on the AH–RIIa interaction in vitro.
Alto, Angelo, Banky, Barber, Brokaw, Burns-Hamuro, Cao, Carr, Carr, Carr, Chen, Cho, Diener, Diener, Fujita, Gaillard, Gaillard, Gold, Greengard, Gupta, Habermacher, Habermacher, Herberg, Hirsch, Howard, Hsu, Huang, Jarnaess, Jennifer M. Dienes, Jiang, Kammerer, Kinderman, Kindle, Klauck, Kohno, Li, Martin St. Maurice, Mastronarde, Mauban, Means, Mitchell, Morikis, Newell, Nicastro, Omoto, Patel, Patel-King, Pauling, Pigino, Pinfen Yang, Priyanka Sivadas, Roguev, Rual, Sarma, Satir, Scott, Silflow, South, Wang, Warner, Wei, Welch, William D. Meek, Williams, Wirschell, Witman, Xia, Xu, Yang, Yang, Yang, Yang   +71 more
core   +2 more sources

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

Cleavage of Armadillo/beta-catenin by the caspase DrICE in apoptotic epithelial cells [PDF]

, 2009
Background: During apoptosis cells become profoundly restructured through concerted cleavage of cellular proteins by caspases. In epithelial tissues, apoptotic cells loose their apical/basal polarity and are extruded from the epithelium.
Thomas Kessler, H Arno J Müller, AH Wyllie, M Sebbagh, ML Coleman, C Brancolini, A Degterev, NA Thornberry, NA Thornberry, NA Thornberry, X Liu, M Enari, U Fischer, J Rosenblatt, HA Müller, H Oda, H Oda, S Yamada, F Drees, T Uemura, U Tepass, RT Cox, U Tepass, HA Müller, WJ Kaiser, SL Wang, L Goyal, S Lisi, D Chandraratna, SJ Yoo, A Rodriguez, AG Fraser, EA Slee, U Steinhusen, Z Song, S Orsulic, LM Pai, B Riggleman, M Peifer, H Kanuka, E Arama, JR Huh, D Xu, F Leulier, A Rodriguez, D Xu, K Mills, SK Chew, TJ Daish, M Srivastava, U Steinhusen, DD Bannerman, C Brancolini, LM Pai, RT Cox, J Castano, L Dorstyn   +56 more
core   +1 more source

HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis

Cell Reports, 2019
Summary: The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability, and DNA interstrand crosslink repair in vertebrates.
Inger Brandsma, Koichi Sato, Sari E. van Rossum-Fikkert, Nicole van Vliet, Esther Sleddens, Marcel Reuter, Hanny Odijk, Nathalie van den Tempel, Dick H.W. Dekkers, Karel Bezstarosti, Jeroen A.A. Demmers, Alex Maas, Joyce Lebbink, Claire Wyman, Jeroen Essers, Dik C. van Gent, Willy M. Baarends, Puck Knipscheer, Roland Kanaar, Alex N. Zelensky   +19 more
doaj   +1 more source

Making Two out of One: Kinesin Motors Driving Plant Cell Division

Cytoskeleton, EarlyView.
ABSTRACT The Kinesin superfamily of microtubule dependent motors is present in all eukaryotes. Not all of the subfamilies are represented in all kingdoms, and the ones that are do not always show conserved functions. Tight control of the cytoskeleton is essential for proper progression and completion of mitosis and cytokinesis, and key functions are ...
Choy Kriechbaum, Sabine Müller
wiley   +1 more source

Phylogenetic differences in content and intensity of periodic proteins [PDF]

, 2005
Many proteins exhibit sequence periodicity, often correlated with a visible structural periodicity. The statistical significance of such periodicity can be assessed by means of a chi-square-based test, with significance thresholds being calculated from ...
Gatherer, D., McEwan, N.R.
core   +1 more source

Identification of whole-cell dsRNA-binding proteins by phase separation

RNA Biology
Interactions between double-stranded RNA (dsRNA) and proteins play an important role in cellular homeostasis by regulating the editing, stability, and splicing of intracellular RNA.
Zhixiang Yang, Junwei Zhou, Zhuang Li, Jiahui Guo, Liurong Fang, Xun Xiao, Shaobo Xiao   +6 more
doaj   +1 more source