Results 41 to 50 of about 8,647 (121)

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Expression of p120-Catenin Isoforms Correlates with Genomic and Transcriptional Phenotype of Breast Cancer Cell Lines

Cellular Oncology, 2007
Background: P120-catenin is a member of the Armadillo protein family, which is involved in intercellular adhesion and cell signalling. It directly interacts with the classical cadherins juxtamembrane domain and contributes for both junction formation and
Joana Paredes, Ana Luísa Correia, Ana Sofia Ribeiro, Fernando Schmitt   +3 more
doaj   +1 more source

Etymology and entomology: The semiotics and ethics of multispecies gene nomenclatures

Journal of Linguistic Anthropology, Volume 36, Issue 2, August 2026.
Abstract This article examines controversies surrounding gene names that are perceived as humorous in the context of fruit flies but are considered rude in the clinical context of human medicine. Drawing on ethnographic fieldwork in insect laboratories, interviews with entomologists and geneticists, and an analysis of scientific and clinical ...
Colin M. E. Halverson
wiley   +1 more source

A new LRRK2 variant in a family with Parkinson’s disease affects binding to RAB8A

npj Parkinson's Disease
Pathogenic variants in the LRRK2 gene affecting catalytic domains are the most common genetic cause of Parkinson’s disease (PD). Nevertheless, LRRK2 variants at the armadillo (ARM) domain would indirectly affect the protein’s activity by interacting with
Lydia Vela-Desojo, Alba Pascual, Victor Montal, Carmen Guerrero, Mireia Osuna-López, Victor Guallar, Francesc Palau, Janet Hoenicka   +7 more
doaj   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, Volume 46, Issue 4, Page 921-944, July 2026.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

Beyond mammals: the evolution of chewing and other forms of oropharyngeal food processing in vertebrates

Biological Reviews, Volume 101, Issue 3, Page 1406-1462, June 2026.
ABSTRACT Oropharyngeal food processing exhibits a remarkable diversity among vertebrates, reflecting the evolution of specialised ‘processing centres’ associated with the mandibular, hyoid, and branchial arches. Although studies have detailed various food‐processing strategies and mechanisms across vertebrates, a coherent and comprehensive terminology ...
Daniel Schwarz, Maja Mielke, Stephan Handschuh, Anthony Herrel, Patrick Lemell, Léa Da Cunha, Nicolai Konow   +6 more
wiley   +1 more source

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, Volume 83, Issue 6, Page 354-375, June 2026.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

Making Two out of One: Kinesin Motors Driving Plant Cell Division

Cytoskeleton, Volume 83, Issue 6, Page 384-393, June 2026.
ABSTRACT The Kinesin superfamily of microtubule dependent motors is present in all eukaryotes. Not all of the subfamilies are represented in all kingdoms, and the ones that are do not always show conserved functions. Tight control of the cytoskeleton is essential for proper progression and completion of mitosis and cytokinesis, and key functions are ...
Choy Kriechbaum, Sabine Müller
wiley   +1 more source

Generalist With a Narrow Niche Breadth: Feeding Ecology and Seed Germination Effectiveness of a Large Canid Within a Silvicultural Matrix

Austral Ecology, Volume 51, Issue 6, June 2026.
Diet: The generalist canid exhibits a narrow niche breadth (0.12), consuming native plants (100% frequency) and animals (85%). Birds dominate animal prey (74%), peaking in the dry season, while Solanaceae plants dominate plant food (100%), peaking in the rainy season.
Aline Carneiro Veloso, Arthur Celestino Soares, Ana Elizabeth Iannini Custódio, Ednaldo Carvalho Guimarães, Carine Firmino Carvalho‐Roel   +4 more
wiley   +1 more source

Examination of actin and microtubule dependent APC localisations in living mammalian cells

BMC Cell Biology, 2006
Background The trafficking of the adenomatous polyposis coli (APC) tumour suppressor protein in mammalian cells is a perennially controversial topic. Immunostaining evidence for an actin-associated APC localisation at intercellular junctions has been ...
Adams Matthew, Lee Tracy, Askham Jon M, Langford Kelly J, Morrison Ewan E   +4 more
doaj   +1 more source