Results 21 to 30 of about 8,647 (121)
Frontiers in Plant Science, 2014 Post-translational protein modification plays a pivotal role in the regulation and specific turnover of proteins. One of these important modifications is the ubiquitination of target proteins, which can occur at distinct cellular compartments.
Katja eVogelmann +6 more
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The Interaction of FABP with Kapα. [PDF]
PLoS ONE, 2015 Gene-activating lipophilic compounds are carried into the nucleus when loaded on fatty-acid-binding proteins (FABP). Some of these proteins are recognized by the α-Karyopherin (Kapα) through its nuclear localization signal (NLS) consisting of three ...
Ortal Amber-Vitos +4 more
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Deciphering the evolution of composite-type GSKIP in mitochondria and Wnt signaling pathways.
PLoS ONE, 2022 We previously revealed the origin of mammalian simple-type glycogen synthase kinase interaction protein (GSKIP), which served as a scavenger and a competitor in the Wnt signaling pathway during evolution.
Cheng-Yu Tsai +12 more
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Molecular Cancer, 2009 Background δ-Catenin is a unique member of β-catenin/armadillo domain superfamily proteins and its primary expression is restricted to the brain. However, δ-catenin is upregulated in human prostatic adenocarcinomas, although the effects of δ-catenin ...
Chen Yan-Hua +7 more
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BiomoleculesPlakophilin 1 (PKP1), a member of the p120ctn subfamily of the armadillo (ARM)-repeat-containing proteins, is an important structural component of cell–cell adhesion scaffolds although it can also be ubiquitously found in the cytoplasm and the nucleus ...
Salome Araujo-Abad +7 more
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Structural characterization of human importin alpha 7 in its cargo-free form at 2.5 Å resolution
Scientific Reports, 2022 Shuttling of macromolecules between nucleus and cytoplasm is a tightly regulated process mediated through specific interactions between cargo and nuclear transport proteins.
S. Tsimbalyuk +2 more
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EFR3A, an Intriguing Gene, and Protein with a Scaffolding Function
CellsThe EFR3 (Eighty-Five Requiring 3) protein and its homologs are rather poorly understood eukaryotic plasma membrane peripheral proteins. They belong to the armadillo-like family of superhelical proteins.
Magdalena Trybus +3 more
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Scientific Reports, 2018 In experimental models, both in vivo and cellular, over-expression of Parkinson’s linked mutant leucine-rich repeat kinase 2 (LRRK2) is sufficient to induce neuronal death. While several cell death associated proteins have been linked to LRRK2, either as
Nasia Antoniou +10 more
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Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer
Cells, 2019 Dengue virus (DENV) threatens almost 70% of the world’s population, with no effective vaccine or therapeutic currently available. A key contributor to infection is nuclear localisation in the infected cell of DENV nonstructural protein 5 (NS5 ...
Sundy N. Y. Yang +9 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source