Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization [PDF]
BMC Bioinformatics, 2003 Background The correct folding and dimerization of tubulins, before their addition to the microtubular structure, needs a group of conserved proteins called cofactors A to E.
Jaroszewski Lukasz +2 more
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Examination of actin and microtubule dependent APC localisations in living mammalian cells [PDF]
BMC Cell Biology, 2006 Background The trafficking of the adenomatous polyposis coli (APC) tumour suppressor protein in mammalian cells is a perennially controversial topic. Immunostaining evidence for an actin-associated APC localisation at intercellular junctions has been ...
Adams Matthew +4 more
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Tandem-repeat protein domains across the tree of life [PDF]
PeerJ, 2015 Tandem-repeat protein domains, composed of repeated units of conserved stretches of 20–40 amino acids, are required for a wide array of biological functions.
Kristin K. Jernigan, Seth R. Bordenstein
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Quaternary structures of Vac8 differentially regulate the Cvt and PMN pathways. [PDF]
, 2020 Armadillo (ARM) repeat proteins constitute a large protein family with diverse and fundamental functions in all organisms, and armadillo repeat domains share high structural similarity. However, exactly how these structurally similar proteins can mediate
Jang, Se Hwan +9 more
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Flotillins directly interact with γ-catenin and regulate epithelial cell-cell adhesion. [PDF]
PLoS ONE, 2013 Flotillin-1 and flotillin-2 are two homologous, membrane raft associated proteins. Although it has been reported that flotillins are involved in cell adhesion processes and play a role during breast cancer progression, thus making them interesting future
Nina Kurrle +5 more
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A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
eLife, 2022 Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease, and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases (Steger et al., 2017).
Edmundo G Vides +10 more
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Functions of p120ctn in development and disease [PDF]
, 2012 p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing.
Pieters, Tim +2 more
core +1 more source
Aedes cadherin receptor that mediates Bacillus thuringiensis Cry11A toxicity is essential for mosquito development. [PDF]
, 2020 Aedes cadherin (AaeCad, AAEL024535) has been characterized as a receptor for Bacillus thuringiensis subsp. israelensis (Bti) Cry11A toxins. However, its role in development is still unknown.
Aimanova, Karly G +2 more
core +2 more sources
Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling [PDF]
, 2012 The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell ...
Pieters, Tim +2 more
core +2 more sources
Functional and genomic analyses of alpha-solenoid proteins. [PDF]
PLoS ONE, 2013 Alpha-solenoids are flexible protein structural domains formed by ensembles of alpha-helical repeats (Armadillo and HEAT repeats among others). While homology can be used to detect many of these repeats, some alpha-solenoids have very little sequence ...
David Fournier +6 more
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