Results 11 to 20 of about 8,647 (121)

pLM‐Repeat: Exploiting the sequence representations of protein language models for sensitive repeat detection [PDF]

open access: yesProtein Science, Volume 35, Issue 5, May 2026.
Abstract Duplication is an essential mechanism of molecular evolution, which operates across biological scales, from whole genomes to single basepairs. Its study is central to understanding protein evolution, but the detection of duplication events often becomes challenging over evolutionary time, due to the accumulating sequence divergence.
Kaiyu Qiu   +2 more
wiley   +2 more sources

Functions of J‐domain proteins in mitochondrial protein biogenesis [PDF]

open access: yesProtein Science, Volume 35, Issue 4, April 2026.
Abstract Mitochondrial biogenesis and functions depend on the import and assembly of more than 1000 proteins that are made as precursors on cytosolic ribosomes. The majority of these precursor proteins are transported from the ribosome to the translocase of the outer membrane (TOM complex), which constitutes the main entry site for mitochondrial ...
Vitasta Tiku   +3 more
wiley   +2 more sources

The novel ITPR1 p.Phe2566Ser variant impairs IP3R1‐mediated Ca2+ release and is associated with ataxia and miosis [PDF]

open access: yesJ Intern Med
Journal of Internal Medicine, Volume 299, Issue 5, Page 643-648, May 2026.
Josephine Wincent   +8 more
wiley   +2 more sources

A core MRB1 complex component is indispensable for RNA editing in insect and human infective stages of Trypanosoma brucei. [PDF]

open access: yesPLoS ONE, 2013
Uridine insertion/deletion RNA editing is a unique and vital process in kinetoplastids, required for creation of translatable open reading frames in most mitochondrially-encoded RNAs.
Michelle L Ammerman   +6 more
doaj   +1 more source

Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization

open access: yesBMC Bioinformatics, 2003
Background The correct folding and dimerization of tubulins, before their addition to the microtubular structure, needs a group of conserved proteins called cofactors A to E.
Jaroszewski Lukasz   +2 more
doaj   +1 more source

Targeting of δ-catenin to postsynaptic sites through interaction with the Shank3 N-terminus

open access: yesMolecular Autism, 2020
Background Neurodevelopmental disorders such as autism spectrum disorder (ASD) may be caused by alterations in genes encoding proteins that are involved in synapse formation and function.
Fatemeh Hassani Nia   +6 more
doaj   +1 more source

A novel Porphyromonas gingivalis enzyme: An atypical dipeptidyl peptidase III with an ARM repeat domain. [PDF]

open access: yesPLoS ONE, 2017
Porphyromonas gingivalis, an asaccharolytic Gram-negative oral anaerobe, is a major pathogen associated with adult periodontitis, a chronic infective disease that a significant percentage of the human population suffers from.
Altijana Hromić-Jahjefendić   +11 more
doaj   +1 more source

Hsp70-nucleotide exchange factor (NEF) Fes1 has non-NEF roles in degradation of gluconeogenic enzymes and cell wall integrity.

open access: yesPLoS Genetics, 2019
Fes1 is a conserved armadillo repeat-containing Hsp70 nucleotide exchange factor important for growth at high temperature, proteasomal protein degradation and prion propagation.
Shailesh Kumar, Daniel C Masison
doaj   +1 more source

A Lotus japonicus E3 ligase interacts with the Nod Factor Receptor 5 and positively regulates nodulation

open access: yesBMC Plant Biology, 2018
Background Post-translational modification of receptor proteins is involved in activation and de-activation of signalling systems in plants. Both ubiquitination and deubiquitination have been implicated in plant interactions with pathogens and symbionts.
Daniela Tsikou   +7 more
doaj   +1 more source

Opposing roles of Fos, Raw, and SARM1 in the regulation of axonal degeneration and synaptic structure

open access: yesFrontiers in Cellular Neuroscience, 2023
IntroductionThe degeneration of injured axons is driven by conserved molecules, including the sterile armadillo TIR domain-containing protein SARM1, the cJun N-terminal kinase JNK, and regulators of these proteins.
Thomas J. Waller   +2 more
doaj   +1 more source

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