Results 11 to 20 of about 8,696 (131)
A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
eLife, 2022 Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease, and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases (Steger et al., 2017).
Edmundo G Vides +10 more
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Functional and genomic analyses of alpha-solenoid proteins. [PDF]
PLoS ONE, 2013 Alpha-solenoids are flexible protein structural domains formed by ensembles of alpha-helical repeats (Armadillo and HEAT repeats among others). While homology can be used to detect many of these repeats, some alpha-solenoids have very little sequence ...
David Fournier +6 more
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2008 Adenomatous polyposis coli (APC) is a multifunctional tumor suppressor protein that negatively regulates the Wnt signaling pathway. The APC gene is ubiquitously expressed in various tissues, especially throughout the large intestine and central nervous system.
Breitman, Maya +3 more
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Biology Direct, 2017 The protein Gcn1 (General control non-derepressible 1) is found in virtually all eukaryotes, and is a key component of the general amino acid control signal transduction pathway.
Ramachandran Rakesh +3 more
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Journal of Theoretical Biology, 2015 Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) is a human oncoprotein, which exerts its cancer-promoting function through interaction with other proteins, for example Protein Phosphatase 2A (PP2A) and MYC. The lack of structural information for CIP2A significantly prevents the design of anti-cancer therapeutics targeting this protein.
Salminen Tiina, Dahlström Käthe
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Aristaless Related Homeobox (ARX) Interacts with β-Catenin, BCL9, and P300 to Regulate Canonical Wnt Signaling. [PDF]
PLoS ONE, 2017 Mutations in the Aristaless Related Homeobox (ARX) gene are associated with a spectrum of structural (lissencephaly) and functional (epilepsy and intellectual disabilities) neurodevelopmental disorders.
Il-Taeg Cho +3 more
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A core MRB1 complex component is indispensable for RNA editing in insect and human infective stages of Trypanosoma brucei. [PDF]
PLoS ONE, 2013 Uridine insertion/deletion RNA editing is a unique and vital process in kinetoplastids, required for creation of translatable open reading frames in most mitochondrially-encoded RNAs.
Michelle L Ammerman +6 more
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Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization
BMC Bioinformatics, 2003 Background The correct folding and dimerization of tubulins, before their addition to the microtubular structure, needs a group of conserved proteins called cofactors A to E.
Jaroszewski Lukasz +2 more
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Targeting of δ-catenin to postsynaptic sites through interaction with the Shank3 N-terminus
Molecular Autism, 2020 Background Neurodevelopmental disorders such as autism spectrum disorder (ASD) may be caused by alterations in genes encoding proteins that are involved in synapse formation and function.
Fatemeh Hassani Nia +6 more
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A novel Porphyromonas gingivalis enzyme: An atypical dipeptidyl peptidase III with an ARM repeat domain. [PDF]
PLoS ONE, 2017 Porphyromonas gingivalis, an asaccharolytic Gram-negative oral anaerobe, is a major pathogen associated with adult periodontitis, a chronic infective disease that a significant percentage of the human population suffers from.
Altijana Hromić-Jahjefendić +11 more
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