Results 1 to 10 of about 15,999 (168)

pLM-Repeat: Exploiting the sequence representations of protein language models for sensitive repeat detection. [PDF]

Protein Sci
Abstract Duplication is an essential mechanism of molecular evolution, which operates across biological scales, from whole genomes to single basepairs. Its study is central to understanding protein evolution, but the detection of duplication events often becomes challenging over evolutionary time, due to the accumulating sequence divergence.
Qiu K, Lupas AN, Dunin-Horkawicz S.
europepmc   +2 more sources

The novel ITPR1 p.Phe2566Ser variant impairs IP₃R1-mediated Ca²⁺ release and is associated with ataxia and miosis. [PDF]

J Intern Med
Journal of Internal Medicine, Volume 299, Issue 5, Page 643-648, May 2026.
Wincent J, Zhang S, Nolan A, Kanatani S, Nordin F, Kvarnung M, Uhlén P, Paucar M, Eidhof I.   +8 more
europepmc   +2 more sources

Functions of J-domain proteins in mitochondrial protein biogenesis. [PDF]

Protein Sci
Abstract Mitochondrial biogenesis and functions depend on the import and assembly of more than 1000 proteins that are made as precursors on cytosolic ribosomes. The majority of these precursor proteins are transported from the ribosome to the translocase of the outer membrane (TOM complex), which constitutes the main entry site for mitochondrial ...
Tiku V, Bossenz G, Kirstein J, Becker T.
europepmc   +2 more sources

Exploring the roles of ZmARM gene family in maize development and abiotic stress response [PDF]

PeerJ, 2023
Armadillo (ARM) was a gene family important to plants, with crucial roles in regulating plant growth, development, and stress responses. However, the properties and functions of ARM family members in maize had received limited attention.
Zhijia Yu, Xiaopeng Sun, Ziqi Chen, Qi Wang, Chuang Zhang, Xiangguo Liu, Weilin Wu, Yuejia Yin   +7 more
doaj   +2 more sources

The ARM repeat domain of hemocyanin interacts with MKK4 to modulate antimicrobial peptides expression

iScience, 2022
Summary: The mitogen-activated protein kinase (MAPK) intracellular signaling pathway mediates numerous biological processes, including antimicrobial immune response by inducing antimicrobial peptides (AMPs) production.
Jude Juventus Aweya, Kaiying Zhuang, Yiqi Liu, Jiaohong Fan, Defu Yao, Fan Wang, Xiaohan Chen, Shengkang Li, Hongyu Ma, Yueling Zhang   +9 more
doaj   +1 more source

ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases

Frontiers in Molecular Biosciences, 2021
Armadillo repeat-containing proteins (ARMCs) are widely distributed in eukaryotes and have important influences on cell adhesion, signal transduction, mitochondrial function regulation, tumorigenesis, and other processes.
Yutao Huang, Yutao Huang, Zijian Jiang, Xiangyu Gao, Xiangyu Gao, Peng Luo, Peng Luo, Xiaofan Jiang, Xiaofan Jiang   +8 more
doaj   +1 more source

Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development. [PDF]

PLoS ONE, 2012
A subset of signaling pathways play exceptionally important roles in embryonic and post-embryonic development, and mis-regulation of these pathways occurs in most human cancers. One such pathway is the Wnt pathway.
David M Roberts, Mira I Pronobis, Kelly M Alexandre, Gregory C Rogers, John S Poulton, Daniel E Schneider, Kuo-Chen Jung, Daniel J McKay, Mark Peifer   +8 more
doaj   +1 more source

An armadillo-domain protein participates in a telomerase interaction network [PDF]

Plant Molecular Biology, 2018
Arabidopsis and human ARM protein interact with telomerase. Deregulated mRNA levels of DNA repair and ribosomal protein genes in an Arabidopsis arm mutant suggest non-telomeric ARM function. The human homolog ARMC6 interacts with hTRF2. Telomerase maintains telomeres and has proposed non-telomeric functions.
Ladislav Dokládal, Eva Benková, David Honys, Nikoleta Dupľáková, Lan-Ying Lee, Stanton B. Gelvin, Eva Sýkorová   +6 more
openaire   +4 more sources

Structures of designed armadillo repeat proteins binding to peptides fused to globular domains [PDF]

Protein Science, 2017
AbstractDesigned armadillo repeat proteins (dArmRP) are α‐helical solenoid repeat proteins with an extended peptide binding groove that were engineered to develop a generic modular technology for peptide recognition. In this context, the term “peptide” not only denotes a short unstructured chain of amino acids, but also an unstructured region of a ...
Hansen, Simon, Kiefer, Jonathan D, Madhurantakam, Chaithanya, Mittl, Peer R E, Plückthun, Andreas   +4 more
openaire   +4 more sources

Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf) [PDF]

The Journal of Cell Biology, 2000
Epsin (Eps15 interactor) is a cytosolic protein involved in clathrin-mediated endocytosis via its direct interactions with clathrin, the clathrin adaptor AP-2, and Eps15. The NH2-terminal portion of epsin contains a phylogenetically conserved module of unknown function, known as the ENTH domain (epsin NH2-terminal homology domain).
J. Hyman, H. Chen, P. P. Di Fiore, P. De Camilli, A. T. Brunger   +4 more
openaire   +2 more sources